In 1719, a deadly and highly contagious disease took hold of the Imperial Villa of Potosí, a silver mining metropolis in what is now Bolivia. Within a year, the pathogen had killed some 22,000 people, just over a third of the city’s residents. Victims collapsed with fever, body aches, and effusions of blood from the nose and mouth. Most died within days. The great Andean pandemic of 1717–22 was likely the most destructive disease to strike South America since the days of the Spanish conquest. Pandemic in Potosí features the single longest narrative of this nearly forgotten period, penned by local historian Bartolomé Arzáns de Orsúa y Vela, along with shorter treatments of the disease’s ravages in Cuzco, Arequipa, and the outskirts of Lima. The “Gran Peste,” as it was called, was a pivotal event about which Arzáns wrote at length because he lived through it, but also because it was believed to have cosmic significance. Kris Lane translates and contextualizes Arzáns’s account, which is rich in local detail that sheds light on a range of topics—from therapeutics, devotional life, class relations, gender, and race to conceptions of illness, sin, and human will and responsibility during a major public health crisis. Original narratives of the pandemic, translated here for the first time, help readers see commonalities and differences between past and present disease encounters. Designed for use in courses on Latin American history, this concise work will also interest scholars and students of the history of religion, history of medicine, urban studies, and epidemiology.

In 1719, a deadly and highly contagious disease took hold of the Imperial Villa of Potosí, a silver mining metropolis in what is now Bolivia. Within a year, the pathogen had killed some 22,000 people, just over a third of the city’s residents. Victims collapsed with fever, body aches, and effusions of blood from the nose and mouth. Most died within days. The great Andean pandemic of 1717–22 was likely the most destructive disease to strike South America since the days of the Spanish conquest. Pandemic in Potosí features the single longest narrative of this nearly forgotten period, penned by local historian Bartolomé Arzáns de Orsúa y Vela, along with shorter treatments of the disease’s ravages in Cuzco, Arequipa, and the outskirts of Lima. The “Gran Peste,” as it was called, was a pivotal event about which Arzáns wrote at length because he lived through it, but also because it was believed to have cosmic significance. Kris Lane translates and contextualizes Arzáns’s account, which is rich in local detail that sheds light on a range of topics—from therapeutics, devotional life, class relations, gender, and race to conceptions of illness, sin, and human will and responsibility during a major public health crisis. Original narratives of the pandemic, translated here for the first time, help readers see commonalities and differences between past and present disease encounters. Designed for use in courses on Latin American history, this concise work will also interest scholars and students of the history of religion, history of medicine, urban studies, and epidemiology.

"For anyone who wants to learn about the rise and decline of Potosí as a city . . . Lane’s book is the ideal place to begin."—The New York Review of Books In 1545, a native Andean prospector hit pay dirt on a desolate red mountain in highland Bolivia. There followed the world's greatest silver bonanza, making the Cerro Rico or "Rich Hill" and the Imperial Villa of Potosí instant legends, famous from Istanbul to Beijing. The Cerro Rico alone provided over half of the world's silver for a century, and even in decline, it remained the single richest source on earth. Potosí is the first interpretive history of the fabled mining city’s rise and fall. It tells the story of global economic transformation and the environmental and social impact of rampant colonial exploitation from Potosí’s startling emergence in the sixteenth century to its collapse in the nineteenth. Throughout, Kris Lane’s invigorating narrative offers rare details of this thriving city and its promise of prosperity. A new world of native workers, market women, African slaves, and other ordinary residents who lived alongside the elite merchants, refinery owners, wealthy widows, and crown officials, emerge in lively, riveting stories from the original sources. An engrossing depiction of excess and devastation, Potosí reveals the relentless human tradition in boom times and bust.

The Coronavirus pandemic is fueling conflict and fostering extremism while concurrently empowering gangs, cartels, and mafias in their quest for power and profit. In COVID-19, Gangs, and Conflict, Editors John P. Sullivan and Robert J. Bunker bring together a curated collection of both new and previously published material to explore the trends and potentials of the global pandemic emergency. Topics include an exploration of proto-statemaking by criminal groups, the interaction of pandemics and conflict, as well as a comparison of gangs, criminal cartels, and mafias exploiting the crisis and exerting criminal governance in Brazil, El Salvador, Mexico, Colombia, and South Africa. Implications for national security, biosecurity, slums, transnational organized crime, and threats and opportunities in the contested pandemic space are assessed. SWJ

Mathematical Modeling, Simulations, and Artificial Intelligence for Emergent Pandemic Diseases: Lessons Learned from COVID-19 includes new research, models and simulations developed during the COVID-19 pandemic into how mathematical methods and practice can impact future response. Chapters go beyond forecasting COVID-19, bringing different scale angles and mathematical techniques (e.g., ordinary differential and difference equations, agent-based models, artificial intelligence, and complex networks) which could have potential use in modeling other emergent pandemic diseases. A major part of the book focuses on preparing the scientific community for the next pandemic, particularly the application of mathematical modeling in ecology, economics and epidemiology. Readers will benefit from learning how to apply advanced mathematical modeling to a variety of topics of practical interest, including optimal allocations of masks and vaccines but also more theoretical problems such as the evolution of viral variants. - Provides a comprehensive overview of the state-of-the-art in mathematical modeling and computational simulations for emerging pandemics - Presents modeling techniques that go beyond COVID-19, and that can be applied to tailoring interventions to attenuate high death tolls - Includes illustrations, tables and dialog boxes to explain highly specialized concepts and insights with complex algorithms, along with links to programming code

Equally concerned with the lives of ordinary Andean people and sweeping historical processes, this book unveils a complex colonial world of indigenous villagers and their Spanish neighbors from the ground up and in the process examines one of the most significant indigenous uprisings in the Americas. This rebellion, known by the name of its leader, T£pac Amaru, ignited in colonial Cuzco near the former Inca capital during the late eighteenth century (1780?83) and spread rapidly throughout much of the Andes. Led by the descendant of the last Inca ruler, the rebellion severely disrupted the colonial economy and proved to be the most serious challenge to Spanish authority in Latin America since the sixteenth century. Focusing on the Cuzco provinces of Quispicanchis and Canas y Canchis, which were the wellspring of the rebellion, Ward Stavig examines the issues, values, and themes central to the lives of ordinary Andean women and men?senses of identity, conceptions of sexuality and gender, the threat of crime, the value placed on work, competition for land and its relation to cultural identity, and the impact of forced labor. Stavig interweaves an intimate and richly textured portrait of the lives of Native villagers with an analysis of economic and political colonial institutions to show not only how Native peoples in Cuzco made sense of their lives but also how their strategies of survival shaped colonial society.

Biomedical Innovations to Combat COVID-19 provides an updated overview on the development of vaccines, antiviral drugs and nanomaterials, and diagnostic methods for the fight against COVID-19. Perspectives on such technologies are identified, discussed, and enriched with figures for easy understanding and applicability. Furthermore, it contains basic aspects of virology, immunology, and antiviral drugs that are needed to fully appreciate these innovations. This book is split into four sections: introduction, presenting basic virologic and epidemiological aspects of COVID-19; vaccines against COVID-19, discussing their different types and applications used to develop them; diagnostic approaches for SARS-CoV-2, encompassing advanced sensing and microfluidic-based biosensors; and drug development and delivery, where antivirals based on nanomaterials or drugs are presented. It is a valuable source for virologists, biotechnologists, and members of biomedical field interested in learning more about how novel technologies can be applied to fasten the eradication of the COVID-19 and similar pandemics. - Presents updated literature coverage summarizing the most relevant information on COVID-19 - Written by experts from diverse scientific domains in order to provide readers with a thorough view on the subject - Encompasses tables, figures and information trees especially developed for the book in order to condense and highlight key points for quick reference

This manifesto is motivated by the daunting psychosocial issues that were so strikingly revealed by the Covid-19 pandemic. Of particular interest is the collective denial of facts, which resulted in public health policy mistakes and fostered distrust. In hindsight, this could have been prevented. Boccara shows how the core psychosocial response to the pandemic observed in most countries turned out to be wishing for it to either magically go away, as if it had never happened or be dealt with in an effortless way. Magical thinking and, as a consequence denying reality, often prevailed. As such, the psychosocial dynamics deepened the denial even further as several countries ended-up deciding to “live with the virus”. Yet, deliberately choosing endemicity of the coronavirus may lead to insurmountable challenges. Humanity is, therefore, truly finding itself at a turning point. Boccara argues that successfully facing systemic challenges ahead will require societies to systematically take into account ways in which psychosocial dynamics -particularly those operating at the societal unconscious level- impact public policy and societal level dialogue. By this, we mean understanding how mental representations and fantasies, shared anxieties, and social defenses mobilized against those anxieties impact the society; in other words how nations function as social systems. There has probably never been a more critical time than now for societies worldwide to approach critical decisions from a psychosocial perspective. Failing to do so could lead to psychosocial tipping points whereas the world as whole would increasingly mobilized regressed defenses that would make it impossible for societies to manage such challenges. There comes a time when ideas potentially capable of profoundly changing the world must be brought to the centers of decision making. That time is now upon us.

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