Cartilage injuries in children and adolescents are increasingly observed, with roughly 20% of knee injuries in adolescents requiring surgery. In the US alone, costs of osteoarthritis (OA) are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are common with OA and are also costly to manage. Articular cartilage's low friction and high capacity to bear load makes it critical in the movement of one bone against another, and its lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue engineering is an emerging technology at the threshold of translation to clinical use. Replacement cartilage can be constructed in the laboratory to recapitulate the functional requirements of native tissues. This book outlines the biomechanical and biochemical characteristics of articular cartilage in both normal and pathological states, through development and aging. It also provides a historical perspective of past and current cartilage treatments and previous tissue engineering efforts. Methods and standards for evaluating the function of engineered tissues are discussed, and current cartilage products are presented with an analysis on the United States Food and Drug Administration regulatory pathways that products must follow to market. This book was written to serve as a reference for researchers seeking to learn about articular cartilage, for undergraduate and graduate level courses, and as a compendium of articular cartilage tissue engineering design criteria. Table of Contents: Hyaline Articular Cartilage / Cartilage Aging and Pathology / In Vitro / Bioreactors / Future Directions

Richly illustrated throughout with actual tissue images, this innovative book shows that the soft-hard tissue junction is best understood in a biomechanical context. The authors describe their pioneering experimental methods, providing an essential structure-function framework for computational modelling, and thereby encouraging the development of more realistic, predictive models of this important tissue junction. Covering the three main musculoskeletal junctions of cartilage-bone, disc-vertebra, and ligament/tendon-bone, the relevant soft tissues are examined with respect to both their own inherent structure and their mode of integration with the hard tissue. The soft-hard tissue interface is explored with a focus on structural damage resulting from overloading, and its associated pathologies. Adopting a multiscale approach, ranging in structural resolution from the macro to fibril levels, this is a must-have guide to the field and an ideal resource for researchers seeking new and creative approaches for studying the joint and spine tissues.

This book presents regenerative strategies for the treatment of knee joint disabilities. The book is composed of four main sections totaling 19 chapters which review the current knowledge on the clinical management and preclinical regenerative strategies. It examines the role of different natural-based biomaterials as scaffolds and implants for addressing different tissue lesions in the knee joint. Section one provides an updated and comprehensive discussion on articular cartilage tissue regeneration. Section two focuses on the important contributions for bone and osteochondral tissue engineering. Section three overview the recent advances on meniscus repair/regeneration strategies. Finally, section four further discusses the current strategies for treatment of ligament lesions. Each chapter is prepared by world know expert on their fields, so we do firmly believe that the proposed book will be a reference in the area of biomaterials for regenerative medicine.

Advances in Tissue Engineering is a unique volume and the first of its kind to bring together leading names in the field of tissue engineering and stem cell research. A relatively young science, tissue engineering can be seen in both scientific and sociological contexts and successes in the field are now leading to clinical reality. This book attempts to define the path from basic science to practical application. A contribution from the UK Stem Cell Bank and opinions of venture capitalists offer a variety of viewpoints, and exciting new areas of stem cell biology are highlighted. With over fifty stellar contributors, this book presents the most up-to-date information in this very topical and exciting field./a

A comprehensive overview of the latest achievements, trends, and the current state of the art of this important and rapidly expanding field. Clearly and logically structured, the first part of the book explores the fundamentals of tissue engineering, providing a separate chapter on each of the basic topics, including biomaterials stem cells, biosensors and bioreactors. The second part then follows a more applied approach, discussing various applications of tissue engineering, such as the replacement or repairing of skins, cartilages, livers and blood vessels, to trachea, lungs and cardiac tissues, to musculoskeletal tissue engineering used for bones and ligaments as well as pancreas, kidney and neural tissue engineering for the brain. The book concludes with a look at future technological advances. An invaluable reading for entrants to the field in biomedical engineering as well as expert researchers and developers in industry.

The growing interest in scaffolding design and increasing research programs dedicated to regenerative medicine corroborate the need for Scaffolding in Tissue Engineering. While certain books and journal articles address various aspects in the field, this is the first current, comprehensive text focusing on scaffolding for tissue engineering.

In this new edition of their classic work on Cellular Solids, the authors have brought the book completely up to date, including new work on processing of metallic and ceramic foams and on the mechanical, electrical and acoustic properties of cellular solids. Data for commercially available foams are presented on material property charts; two new case studies show how the charts are used for selection of foams in engineering design. Over 150 references appearing in the literature since the publication of the first edition are cited. The text summarises current understanding of the structure and mechanical behaviour of cellular materials, and the ways in which they can be exploited in engineering design. Cellular solids include engineering honeycombs and foams (which can now be made from polymers, metals, ceramics and composites) as well as natural materials, such as wood, cork and cancellous bone.

This textbook covers all the steps in manufacturing a biomedical product from bench to bedside. It specifically focuses on quality assurance and management and explains the different good practice principles in the various phases of product development as well as how to fulfill them: Good laboratory practice, good manufacturing practice and good clinical practice. It provides readers with the know-how to design biomedical experiments to ensure quality and integrity, to plan and conduct standard preclinical studies and to assure the quality of the final manufactured biomedical products. Importantly, it also addresses ethical concerns and considerations. The book discusses the guidelines and ethical considerations for preclinical and clinical studies, to allow readers to identify safety concerns regarding biomedical products and to improve pre-clinical studies for the development of better products. This textbook is a valuable guide for biomedical students (B.Sc., M.S., and Ph.D. students) in the field of molecular medicine, medical biotechnology, stem cell research and related areas, as well as for professionals such as quality control staff, tissue bankers, policy-makers and health professionals.

Biocomposites are widely used in the medical industry to repair and restore bone, tooth, cartilage skin and other tissues. Biomedical composites, provides a thorough review of the current status, recent progress and future trends in composites for biomedical applications.Part one discusses the fundamentals of biocomposites with chapters on natural composites, design and fabrication of biocomposites, and hard and soft tissue applications of biocomposites. Part two then reviews applications of biocomposites. Chapters discuss composites for bone repair, composite coatings for implants, composites for spinal implants, injectable composites and composites for tissue engineered scaffolds. Chapters in part three discuss the biocompatibility, mechanical behaviour and failure of biocomposites with such topics as cellular response, testing of biocomposites and tribology of biocomposites. Finally part four reviews the future for biocomposites with chapters on nano-structured biocomposites, developing biocomposites as scaffolds and biocomposites in tissue engineering and regenerative medicine.With its distinguished editor and team of international contributors, Biomedical composites is an essential reference to materials scientists and researchers in industry and academia, as well as all those concerned with this increasingly important field. - Provides a thorough review of the current status, recent progress and future trends in composites for biomedical applications - Discusses the fundamentals of biocomposites with chapters on natural composites, design and fabrication of biocomposites and their applications - Chapters address composites for bone repair, spinal implants and various other applications and discuss biocompatability, mechanical behaviour and failure of biocomposites

This user-friendly, pragmatic book discusses the normal and pathological conditions of the appendicular skeleton, with a focus on the preservation of joint function, providing a detailed overview of strategies for both common and complex joint preservation. The first section covers basic topics, ranging from joints homeostasis and biomechanics, to genetics, bio-orthopedics, tissue engineering and 3D bioprinting. The following sections are each dedicated to a specific joint – its functional anatomy, pathologic conditions, diagnostics and treatment. This book is of interest to orthopedists and sports medicine specialists treating common and complex injuries of the joints.