This Springer brief discusses the use of control engineering methods to plan a cancer therapy which tends to reduce tumour size in patients, striking a balance that minimizes the toxic effects of the treatment. The authors address the design and computation of impulsive control therapies, a methodology previously underexplored in the application of control methods to medical modelling. This allows simulation of such discrete events as taking a pill rather than relying on the supply of therapy being continuous and steady. The book begins with an introduction to the topic, before moving onto pharmacokinetic, pharmacodynamical and tumour-growth models and explaining how they describe the relationship between a certain therapy plan and the evolution of cancer. This is placed firmly in the context of work introducing impulsive differential equations. The final chapter summarizes the research presented and suggests future areas of research to encourage readers in taking the subject forward. This book is of interest to biomedical engineers, researchers and students, particularly those with a background in systems and control engineering.

This book, dedicated to Professor Georgi M. Dimirovski on his anniversary, contains new research directions, challenges, and many relevant applications related to many aspects within the broadly perceived areas of systems and control, including signal analysis and intelligent systems. The project comprises two volumes with papers written by well known and very active researchers and practitioners. The first volume is focused on more foundational aspects related to general issues in systems science and mathematical systems, various problems in control and automation, and the use of computational and artificial intelligence in the context of systems modeling and control. The second volume is concerned with a presentation of relevant applications, notably in robotics, computer networks, telecommunication, fault detection/diagnosis, as well as in biology and medicine, and economic, financial, and social systems too.

Optimal Impulsive Control explores the class of impulsive dynamic optimization problems—problems that stem from the fact that many conventional optimal control problems do not have a solution in the classical setting—which is highly relevant with regard to engineering applications. The absence of a classical solution naturally invokes the so-called extension, or relaxation, of a problem, and leads to the notion of generalized solution which encompasses the notions of generalized control and trajectory; in this book several extensions of optimal control problems are considered within the framework of optimal impulsive control theory. In this framework, the feasible arcs are permitted to have jumps, while the conventional absolutely continuous trajectories may fail to exist. The authors draw together various types of their own results, centered on the necessary conditions of optimality in the form of Pontryagin’s maximum principle and the existence theorems, which shape a substantial body of optimal impulsive control theory. At the same time, they present optimal impulsive control theory in a unified framework, introducing the different paradigmatic problems in increasing order of complexity. The rationale underlying the book involves addressing extensions increasing in complexity from the simplest case provided by linear control systems and ending with the most general case of a totally nonlinear differential control system with state constraints. The mathematical models presented in Optimal Impulsive Control being encountered in various engineering applications, this book will be of interest to both academic researchers and practising engineers.

This third of three volumes includes papers from the second series of NODYCON, which was held virtually in February of 2021. The conference papers reflect a broad coverage of topics in nonlinear dynamics, ranging from traditional topics from established streams of research to those from relatively unexplored and emerging venues of research. These include · Complex dynamics of COVID-19: modeling, prediction and control · Nonlinear phenomena in bio-systems and eco-systems · Energy harvesting · MEMS/NEMS · Multifunctional structures, materials and metamaterials · Nonlinear waves · Chaotic systems, stochasticity, and uncertainty

Automated Drug Delivery in Anesthesia provides a full review of available tools and methods on the drug delivery of anesthesia, bridging the gap between academic development, research and clinical practice. The book takes an interdisciplinary approach, pulling information about tools developed in other disciplines such as mathematics, physics, biology and system engineering and applying them to drug delivery. The book's authors discuss the missing element of complete regulatory loop of anesthesia: the sensor and model for pain pathway assessment. This is the only book which focuses specifically on the delivery of anesthesia. - Revisits the standard TCI anesthesia regulatory loop - Provides complementary measurement devices and protocols for hypnosis, analgesia and neuromuscular blockade (the three components for anesthesia) - Describes the link between existing and emerging tools

This book presents applications of geometric optimal control to real life biomedical problems with an emphasis on cancer treatments. A number of mathematical models for both classical and novel cancer treatments are presented as optimal control problems with the goal of constructing optimal protocols. The power of geometric methods is illustrated with fully worked out complete global solutions to these mathematically challenging problems. Elaborate constructions of optimal controls and corresponding system responses provide great examples of applications of the tools of geometric optimal control and the outcomes aid the design of simpler, practically realizable suboptimal protocols. The book blends mathematical rigor with practically important topics in an easily readable tutorial style. Graduate students and researchers in science and engineering, particularly biomathematics and more mathematical aspects of biomedical engineering, would find this book particularly useful.

Impulsive Control in Continuous and Discrete-Continuous Systems is an up-to-date introduction to the theory of impulsive control in nonlinear systems. This is a new branch of the Optimal Control Theory, which is tightly connected to the Theory of Hybrid Systems. The text introduces the reader to the interesting area of optimal control problems with discontinuous solutions, discussing the application of a new and effective method of discontinuous time-transformation. With a large number of examples, illustrations, and applied problems arising in the area of observation control, this book is excellent as a textbook or reference for a senior or graduate-level course on the subject, as well as a reference for researchers in related fields.