One Step Generation Of A Drug Releasing Microarray For High Throughput Small Volume Bioassays
Download One Step Generation Of A Drug Releasing Microarray For High Throughput Small Volume Bioassays full books in PDF, epub, and Kindle. Read online free One Step Generation Of A Drug Releasing Microarray For High Throughput Small Volume Bioassays ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads.
Author |
: Seo Woo Song |
Publisher |
: Springer |
Total Pages |
: 71 |
Release |
: 2019-05-13 |
ISBN-10 |
: 9789811380945 |
ISBN-13 |
: 9811380945 |
Rating |
: 4/5 (45 Downloads) |
Synopsis One-Step Generation of a Drug-Releasing Microarray for High-Throughput Small-Volume Bioassays by : Seo Woo Song
This thesis demonstrates a technology that enables pipetting-free high-throughput screening (HTS) on a miniaturized platform, eliminating the need for thousands of one-by-one pipetting and conventional liquid handling systems. This platform enhances accessibility to HTS and enables HTS to be used in small-to-medium scale laboratories. In addition, it allows large-scale combinatorial screening with a small number of valuable cells, such as patients’ primary cancer cells. This technique will have a high impact for widespread use of HTS in the era of personalized medicine. In this thesis, the author firstly describes the need and concept of ‘partipetting’ for pipetting-free HTS platform. It is realized by the one-step pipetting and self-assembly of encoded drug-laden microparticles (DLPs) on the microwells. Next, the technical implementations required for the platform demonstration are described. It includes preparation of encoded DLPs, plastic chip fabrication, and realization of automated system. Lastly, screening of sequential drug combinations using this platform is demonstrated. This shows the potential of the proposed technology for various applications.
Author |
: Seo Woo Song |
Publisher |
: |
Total Pages |
: 71 |
Release |
: 2019 |
ISBN-10 |
: 9811380953 |
ISBN-13 |
: 9789811380952 |
Rating |
: 4/5 (53 Downloads) |
Synopsis One-step Generation of a Drug-releasing Microarray for High-throughput Small-volume Bioassays by : Seo Woo Song
This thesis demonstrates a technology that enables pipetting-free high-throughput screening (HTS) on a miniaturized platform, eliminating the need for thousands of one-by-one pipetting and conventional liquid handling systems. This platform enhances accessibility to HTS and enables HTS to be used in small-to-medium scale laboratories. In addition, it allows large-scale combinatorial screening with a small number of valuable cells, such as patients primary cancer cells. This technique will have a high impact for widespread use of HTS in the era of personalized medicine. In this thesis, the author firstly describes the need and concept of 'partipetting for pipetting-free HTS platform. It is realized by the one-step pipetting and self-assembly of encoded drug-laden microparticles (DLPs) on the microwells. Next, the technical implementations required for the platform demonstration are described. It includes preparation of encoded DLPs, plastic chip fabrication, and realization of automated system. Lastly, screening of sequential drug combinations using this platform is demonstrated. This shows the potential of the proposed technology for various applications.
Author |
: Dong-Young Noh |
Publisher |
: Springer Nature |
Total Pages |
: 630 |
Release |
: 2021-05-13 |
ISBN-10 |
: 9789813296206 |
ISBN-13 |
: 9813296208 |
Rating |
: 4/5 (06 Downloads) |
Synopsis Translational Research in Breast Cancer by : Dong-Young Noh
This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.
Author |
: Institute of Medicine |
Publisher |
: National Academies Press |
Total Pages |
: 354 |
Release |
: 2012-09-13 |
ISBN-10 |
: 9780309224185 |
ISBN-13 |
: 0309224187 |
Rating |
: 4/5 (85 Downloads) |
Synopsis Evolution of Translational Omics by : Institute of Medicine
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Author |
: Institute of Medicine |
Publisher |
: National Academies Press |
Total Pages |
: 107 |
Release |
: 2014-02-06 |
ISBN-10 |
: 9780309292498 |
ISBN-13 |
: 0309292492 |
Rating |
: 4/5 (98 Downloads) |
Synopsis Improving and Accelerating Therapeutic Development for Nervous System Disorders by : Institute of Medicine
Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
Author |
: Qingjun Liu |
Publisher |
: Artech House |
Total Pages |
: 291 |
Release |
: 2009-10 |
ISBN-10 |
: 9781596934405 |
ISBN-13 |
: 1596934409 |
Rating |
: 4/5 (05 Downloads) |
Synopsis Cell-based Biosensors by : Qingjun Liu
Written by recognized experts the field, this leading-edge resource is the first book to systematically introduce the concept, technology, and development of cell-based biosensors. You find details on the latest cell-based biosensor models and novel micro-structure biosensor techniques. Taking an interdisciplinary approach, this unique volume presents the latest innovative applications of cell-based biosensors in a variety of biomedical fields. The book also explores future trends of cell-based biosensors, including integrated chips, nanotechnology and microfluidics. Over 140 illustrations help clarify key topics throughout the book.
Author |
: Savas Tasoglu |
Publisher |
: MDPI |
Total Pages |
: 213 |
Release |
: 2019-01-10 |
ISBN-10 |
: 9783038974673 |
ISBN-13 |
: 3038974676 |
Rating |
: 4/5 (73 Downloads) |
Synopsis 3D Printed Microfluidic Devices by : Savas Tasoglu
This book is a printed edition of the Special Issue "3D Printed Microfluidic Devices" that was published in Micromachines
Author |
: Li Di |
Publisher |
: Elsevier |
Total Pages |
: 549 |
Release |
: 2010-07-26 |
ISBN-10 |
: 9780080557618 |
ISBN-13 |
: 0080557619 |
Rating |
: 4/5 (18 Downloads) |
Synopsis Drug-like Properties: Concepts, Structure Design and Methods by : Li Di
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. - Serves as an essential working handbook aimed at scientists and students in medicinal chemistry - Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies - Discusses improvements in pharmacokinetics from a practical chemist's standpoint
Author |
: Marek Domin |
Publisher |
: Royal Society of Chemistry |
Total Pages |
: 528 |
Release |
: 2014-11-25 |
ISBN-10 |
: 9781849739269 |
ISBN-13 |
: 1849739269 |
Rating |
: 4/5 (69 Downloads) |
Synopsis Ambient Ionization Mass Spectrometry by : Marek Domin
Ambient ionization has emerged as one of the hottest and fastest growing topics in mass spectrometry enabling sample analysis with minimal sample preparation. Introducing the subject and explaining the basic concepts and terminology, this book will provide a comprehensive, unique treatise devoted to the subject. Written by acknowledged experts, there are full descriptions on how new ionization techniques work, with an overview of their strengths, weaknesses and applications. This title will bring the reader right up to date, with both applications and theory, and will be suitable as a tutorial text for those starting in the field from a variety of disciplines.
Author |
: Richard Durbin |
Publisher |
: Cambridge University Press |
Total Pages |
: 372 |
Release |
: 1998-04-23 |
ISBN-10 |
: 9781139457392 |
ISBN-13 |
: 113945739X |
Rating |
: 4/5 (92 Downloads) |
Synopsis Biological Sequence Analysis by : Richard Durbin
Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.