Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered.

Emphasizing the finite difference approach for solving differential equations, the second edition of Numerical Methods for Engineers and Scientists presents a methodology for systematically constructing individual computer programs. Providing easy access to accurate solutions to complex scientific and engineering problems, each chapter begins with objectives, a discussion of a representative application, and an outline of special features, summing up with a list of tasks students should be able to complete after reading the chapter- perfect for use as a study guide or for review. The AIAA Journal calls the book "...a good, solid instructional text on the basic tools of numerical analysis."

Mathematical models are used to convert real-life problems using mathematical concepts and language. These models are governed by differential equations whose solutions make it easy to understand real-life problems and can be applied to engineering and science disciplines. This book presents numerical methods for solving various mathematical models. This book offers real-life applications, includes research problems on numerical treatment, and shows how to develop the numerical methods for solving problems. The book also covers theory and applications in engineering and science. Engineers, mathematicians, scientists, and researchers working on real-life mathematical problems will find this book useful.

Learn to fully harness the power of Microsoft Excel® to perform scientific and engineering calculations With this text as your guide, you can significantly enhance Microsoft Excel's® capabilities to execute the calculations needed to solve a variety of chemical, biochemical, physical, engineering, biological, and medicinal problems. The text begins with two chapters that introduce you to Excel's Visual Basic for Applications (VBA) programming language, which allows you to expand Excel's® capabilities, although you can still use the text without learning VBA. Following the author's step-by-step instructions, here are just a few of the calculations you learn to perform: Use worksheet functions to work with matrices Find roots of equations and solve systems of simultaneous equations Solve ordinary differential equations and partial differential equations Perform linear and non-linear regression Use random numbers and the Monte Carlo method This text is loaded with examples ranging from very basic to highly sophisticated solutions. More than 100 end-of-chapter problems help you test and put your knowledge to practice solving real-world problems. Answers and explanatory notes for most of the problems are provided in an appendix. The CD-ROM that accompanies this text provides several useful features: All the spreadsheets, charts, and VBA code needed to perform the examples from the text Solutions to most of the end-of-chapter problems An add-in workbook with more than twenty custom functions This text does not require any background in programming, so it is suitable for both undergraduate and graduate courses. Moreover, practitioners in science and engineering will find that this guide saves hours of time by enabling them to perform most of their calculations with one familiar spreadsheet package

Stochastic Numerical Methods introduces at Master level the numerical methods that use probability or stochastic concepts to analyze random processes. The book aims at being rather general and is addressed at students of natural sciences (Physics, Chemistry, Mathematics, Biology, etc.) and Engineering, but also social sciences (Economy, Sociology, etc.) where some of the techniques have been used recently to numerically simulate different agent-based models. Examples included in the book range from phase-transitions and critical phenomena, including details of data analysis (extraction of critical exponents, finite-size effects, etc.), to population dynamics, interfacial growth, chemical reactions, etc. Program listings are integrated in the discussion of numerical algorithms to facilitate their understanding. From the contents: Review of Probability Concepts Monte Carlo Integration Generation of Uniform and Non-uniform Random Numbers: Non-correlated Values Dynamical Methods Applications to Statistical Mechanics Introduction to Stochastic Processes Numerical Simulation of Ordinary and Partial Stochastic Differential Equations Introduction to Master Equations Numerical Simulations of Master Equations Hybrid Monte Carlo Generation of n-Dimensional Correlated Gaussian Variables Collective Algorithms for Spin Systems Histogram Extrapolation Multicanonical Simulations

Following a unique approach, this innovative book integrates the learning of numerical methods with practicing computer programming and using software tools in applications. It covers the fundamentals while emphasizing the most essential methods throughout the pages. Readers are also given the opportunity to enhance their programming skills using MATLAB to implement algorithms. They'll discover how to use this tool to solve problems in science and engineering.

Python Programming and Numerical Methods: A Guide for Engineers and Scientists introduces programming tools and numerical methods to engineering and science students, with the goal of helping the students to develop good computational problem-solving techniques through the use of numerical methods and the Python programming language. Part One introduces fundamental programming concepts, using simple examples to put new concepts quickly into practice. Part Two covers the fundamentals of algorithms and numerical analysis at a level that allows students to quickly apply results in practical settings. - Includes tips, warnings and "try this" features within each chapter to help the reader develop good programming practice - Summaries at the end of each chapter allow for quick access to important information - Includes code in Jupyter notebook format that can be directly run online

Numerical Methods and Methods of Approximation in Science and Engineering prepares students and other readers for advanced studies involving applied numerical and computational analysis. Focused on building a sound theoretical foundation, it uses a clear and simple approach backed by numerous worked examples to facilitate understanding of numerical methods and their application. Readers will learn to structure a sequence of operations into a program, using the programming language of their choice; this approach leads to a deeper understanding of the methods and their limitations. Features: Provides a strong theoretical foundation for learning and applying numerical methods Takes a generic approach to engineering analysis, rather than using a specific programming language Built around a consistent, understandable model for conducting engineering analysis Prepares students for advanced coursework, and use of tools such as FEA and CFD Presents numerous detailed examples and problems, and a Solutions Manual for instructors

The most difficult computational problems nowadays are those of higher dimensions. This research monograph offers an introduction to tensor numerical methods designed for the solution of the multidimensional problems in scientific computing. These methods are based on the rank-structured approximation of multivariate functions and operators by using the appropriate tensor formats. The old and new rank-structured tensor formats are investigated. We discuss in detail the novel quantized tensor approximation method (QTT) which provides function-operator calculus in higher dimensions in logarithmic complexity rendering super-fast convolution, FFT and wavelet transforms. This book suggests the constructive recipes and computational schemes for a number of real life problems described by the multidimensional partial differential equations. We present the theory and algorithms for the sinc-based separable approximation of the analytic radial basis functions including Green’s and Helmholtz kernels. The efficient tensor-based techniques for computational problems in electronic structure calculations and for the grid-based evaluation of long-range interaction potentials in multi-particle systems are considered. We also discuss the QTT numerical approach in many-particle dynamics, tensor techniques for stochastic/parametric PDEs as well as for the solution and homogenization of the elliptic equations with highly-oscillating coefficients. Contents Theory on separable approximation of multivariate functions Multilinear algebra and nonlinear tensor approximation Superfast computations via quantized tensor approximation Tensor approach to multidimensional integrodifferential equations

This title will give readers the possibility of finding very important mathematical tools for working with fractional models and solving fractional differential equations, such as a generalization of Stirling numbers in the framework of fractional calculus and a set of efficient numerical methods.