This issue of Hematology/Oncology Clinics of North America, devoted to Multiple Myeloma, is edited by Dr. Kenneth C. Anderson. Articles in this issue include: Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma; Diagnosis and Risk Stratification in Myeloma; Treatment of Newly Diagnosed Transplant Eligible Patients; Treatment of Newly Diagnosed Transplant Ineligible Patients; Treatment of Relapsed/Refractory Myeloma; Maintenance Therapy; Novel Targeted Therapies; Novel Immune-based Therapies; Allotransplantation in Myeloma; and Waldenstrom’s Macroglobulinemia.

In this issue of Hematology/Oncology Clinics, guest editor Dr. P. Leif Bergsagel brings his considerable expertise to the topic of New Developments in Myeloma. With the advent of next generation sequencing and immune profiling technologies, marked advances have been made recently in the understanding of the molecular and immune pathogenesis of multiple myeloma. Yet even with these advances, there is a continual search for new therapeutic approaches. In this issue, top experts discuss a full range of clinically relevant topics in this complex and fast-changing field. Contains 16 relevant, practice-oriented topics including molecular pathogenesis of multiple myeloma; monoclonal antibodies in the treatment of multiple myeloma; CAR-T cells in the treatment of multiple myeloma; management of newly diagnosed multiple myeloma today, and in the future; approach to high-risk multiple myeloma; new therapies on the horizon for relapsed refractory multiple myeloma; and more. Provides in-depth clinical reviews on new developments in myeloma, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Hematology/Oncology Clinics, guest editors Drs. Bradley A. McGregor and Toni K. Choueiri bring their considerable expertise to the topic of Renal Cell Cancer. Top experts in the field cover key topics such as VHL and HIF at the center of renal cell cancer biology; immunobiology and metabolic pathways of renal cell cancer; hereditary renal cell cancer syndromes; the role of the pathologist in renal cell cancer; novel imaging in renal cell cancer; and more. - Contains 18 relevant, practice-oriented topics including the role of surgery in metastatic renal cell cancer; emerging biomarkers in metastatic renal cell cancer; choosing the right treatment for renal cell cancer of variant histology; novel targets in the treatment of renal cell cancer; and more. - Provides in-depth clinical reviews on renal cell cancer, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Hematology/Oncology Clinics, guest editor Dr. David E. Fisher brings his considerable expertise to the topic of Cutaneous Oncology. Top experts first provide information on skin structure, function, and immunology, then offer overviews of the therapeutic state of the art for both melanoma and non-melanoma skin cancers. Discussions focus on unique clinical challenges and biological breakthroughs which have come to light in recent studies of cutaneous malignancies. - Contains 16 relevant, practice-oriented topics including high risk non-melanoma skin cancers; progress in immune checkpoints for melanoma therapy; targeted therapy innovations for melanoma; advances in vaccines for melanoma; microbiome and immunotherapy; Merkel cell carcinoma; and more. - Provides in-depth clinical reviews on cutaneous oncology, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Topics include: Why does my patient have leukocytosis?, Why Is My Patient Neutropenic?, Does My Patient with a Serum Monoclonal Spike have Multiple Myeloma?, DVT and Pulmonary Embolism, Why Does My Patient Have Lymphadenopathy/Splenomegaly?,and Why Does My Patient have Thrombocytopenia?

Topics include: Targeting IGF-1R, Tyrosine Kinase Inhibitors in Lung Cancer, Targeting mTOR, Targeting Hedgehog, Mitotic Inhibitors, Topoisomerase I Inhibitors , and New Strategies and Drugs Inhibiting Folate Pathways.

In this issue of Hematology/Oncology Clinics, guest editor David H. Ilson brings his considerable expertise to the topic of Malignancies of the Upper GI Tract. - Contains 12 relevant, practice-oriented topics including Advances in the Imaging of Esophageal and Gastroesophageal Junction Malignancies; Advances in Immunotherapy in Esophagogastric Cancer; Advances in Surgery and (Neo) Adjuvant Therapy in the Management of Pancreatic Cancer; Advances in the Surgical Management of Esophageal Cancer; and more. - Provides in-depth clinical reviews on malignancies of the upper GI tract, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Hematology/Oncology Clinics, guest editors Drs. Alexandra P. Wolanskyj-Spinner and Ronald S. Go bring their considerable expertise to the topic of New Developments in the Understanding and Treatment of Autoimmune Hemolytic Anemia. Top experts in the field cover key topics such as warm AIHA; cold AIHA; drug-induced AIHA; adult Evans syndrome; immunotherapy-associated AIHA; complications of AIHA; and more. - Contains 11 relevant, practice-oriented topics including diagnosis and differential diagnosis; red cell antigens and antibodies; traditional and novel tests; DAT neg AIHA; and more. - Provides in-depth clinical reviews on new developments in the understanding and treatment of autoimmune hemolytic anemia, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Hematology/Oncology Clinics, guest editor Dr. Elizabeth K. O'Donnell brings her considerable expertise to the topic of Cancer Precursor Syndromes and Their Detection. Top experts focus on cancer precursors for different sites, with articles on the risk-benefit analysis of early interception; plasma cell precursors; early detection and interception of lung cancer, cervical cancer, GI cancers, skin cancer; and head and neck cancer; biomarkers and early detection; and more. - Contains 12 relevant, practice-oriented topics including clonal hematopoiesis of indeterminate potential (CHIP); prostate cancer: early detection and intervention; ductal carcinoma in situ; cancer prevention; and more. - Provides in-depth clinical reviews on cancer precursor syndromes and their detection, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Hematology/Oncology Clinics, guest editors Drs. Caron A. Jacobson and Parth S. Shah bring their considerable expertise to the topic of CAR T-Cell Therapy. Top experts in the field discuss the multiple ways CAR T-cell therapy can be used to help fight a variety of cancers, such as diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, mantle cell lymphoma, multiple myeloma, and B-cell acute lymphoblastic leukemia (ALL). Contains 12 practice-oriented topics including CAR T-cells in aggressive B-cell lymphomas; CAR T-cells in multiple myeloma; CAR T-cells in AML; mechanisms of resistance of CAR T-cell therapy; the role of CAR T-cell therapy in the era of bispecific antibodies; and more. Provides in-depth clinical reviews on CAR T-cell therapy, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.