Multiple sclerosis is the most common neurological disease affecting young and middle-aged adults, and while much is known about its classic motor and sensory symptoms, it has only been during the past decade, with the advent of specialized neuropsychological test procedures and brain imaging methods, that the cognitive and behavioral changes associated with the disorder have come to be better understood. This book charts that recent progress. It provides a balanced, interdisciplinary view, covering the prevalence, range, type, and course of cognitive and affective disturbances in multiple sclerosis; the interrelationship of the neurobehavioral disturbance with brain abnormalities as visualized by neuroimaging; and the impact of cognitive and behavioral disabilities on patient rehabilitation. The book will be of value to all physicians and psychologists who deal with MS patients. It will update their knowledge of the disease and its ramifications, and will help in communicating this information to patients and their families.

Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.

A unique resource for all health care practitioners caring for people with multiple sclerosis. Endorsed by The Consortium of Multiple Sclerosis Centers Multiple sclerosis (MS), a progressive neurologic disease, is characterized by a host of physical symptoms. But the neurobehavioral consequences of MS can be as devastating and debilitating as physical symptoms, and they are often unreported and undertreated. In this new book, Dr. Anthony Feinstein, a neuropsychiatrist, documents the effects of MS on cognition, information processing speed, learning and memory, executive function, personality, mood, and behavior. Feinstein touches on a number of topics, including • the common cognitive challenges that occur with MS, such as slowed information processing speed, impaired memory, and executive function deficits • psychiatric disorders that accompany MS, such as depression and psychosis • current neuropsychological, brain MRI, and treatment data applicable to the psychiatric and cognitive disorders Mind, Mood, and Memory in Multiple Sclerosis is enhanced both by the latest science and by eloquent case histories that illustrate each cognitive and emotional disorder. Feinstein also provides recommendations for evidence-based therapeutic interventions. Written in an immediate, accessible way, this book has a crossover appeal, making it of interest not only to neurologists, psychiatrists, neuropsychiatrists, neuropsychologists, psychologists, occupational therapists, and nurses but also to people with MS and their caregivers, family, and friends.

Multiple sclerosis is the most common cause of neurological disability in young and middle-aged adults. This fully updated and revised new edition provides a detailed account of the many neuropsychiatric disorders associated with MS and is relevant to both the research and the clinical setting. Using the latest brain imaging findings and results from treatment trials, the symptoms, assessment, diagnosis, and treatment of depression in MS are covered, as are psychosocial factors and the link between depression and MRI abnormalities. Subsequent chapters focus on cognitive dysfunction in MS, including the natural history of cognitive change, the use of screening instruments and neuropsychological batteries, brain imaging correlations and management strategies. The book concludes with a survey of the behavioral benefits and risks associated with disease-modifying drugs. It will be valuable to all mental health professionals, neurologists, and others caring for those affected by MS.

Multiple sclerosis (MS) is an immune-mediated neurodegenerative disorder of the human central nervous system (CNS) which usually affects young adults with certain genetic backgrounds who are then exposed to certain precipitating environmental antigen(s). Despite major advances of the past two decades in understanding the pathophysiology of MS, and in spite of the introduction of new immunomodulatory and immuno-suppressive agents which may slow down disease progression and delay the onset of disability, the "cause and the "cure for MS remain elusive. This volume of International Review of Neurobiology focuses on MS and related disorders. The volume can be divided into various sections with the main emphasis on MS pathogenesis, clinical features and epidemiology, neuroimaging, and treatment. The ultimate goal of this book is to encourage further research into the pathogenesis of this elusive disease.

The author has written an easily accessible summary of neuropsychological tests, neuropsychiatric disorders, and the relationships of test performance to disorder and treatment strategy. This ready reference provides neuropsychologists with an understanding of the medical context within which neuropsychological evaluation and psychosocial therapy takes place.

This book considers the contribution of white matter to cognition and emotion. Every chapter has been rewritten and two new ones added. White matter dementia is updated, and the concept of mild cognitive dysfunction proposed. A unifying theme is connectivity within neural networks by which the human mind is organized.

Dear Readers, If you are engaged in the treatment of patients with MS (pwMS), this e-book’s aim is to offer novel insights to improve on an understanding of one of the major problems of pwMS: fatigue. Although there is increasing research into fatigue and its impact on MS, this collection of ten articles supports a better understanding of fatigue in MS patients. It explores pathophysiological concepts, provoking mechanisms, objective measurements, personality interactions, pharmacological and non-pharmacological interventions and summarizes clinical management. It is written by neurologists, psychologists, scientists and therapists and addresses this group of people, who deal with pwMS in private, clinical, rehabilitation or scientific settings. Its aim is to communicate high-quality information, knowledge and experience on MS to healthcare professionals, while providing global support for the international MS community.

Presenting the novel concept of white matter dementia, this unique book offers hope for a better understanding and treatment of dementia.

This important subject of Diagnosis of and Treatment for Neurobehavioral manifestations of neurologic disease is directed by three leaders of this field - Dr. Alizeza Minagar, Dr. Glen Finney, and Dr. Kenneth Heilman. Topics include: Neurobehavioral testing for mental status; Behavioral neurology of vascular neurology; Alzheimer's disease; Frontotemporal dementia; Traumatic brain injury; Parkinsonian Syndromes (e.g., Parkinson's disease, Lewy body dementia, progressive supranuclear palsy, corticobasal disease, multisystem atrophy); Behavioral neurology of multiple sclerosis and autoimmune encephalopathies; Infectious Diseases (Neuro-AIDS, Neurosyphilis, HSV); Neurobehavioral aspects of systemic disease; Neurobehavioral aspects of epilepsy; Behavioral neurology aspects of nutritional deficiencies; Neurobehavioral aspects of mitochondrial disease; and Medicinal-induced behavioral disorders.