Introduction to Clinical Immunology provides an introduction to clinical immunology, which is described as the application of immunological principles to achieve a better understanding of the mechanisms of human diseases and appropriate laboratory investigations. This book discusses immunoglobulins, monoclonal immunoglobulins, IgE and atopic disease, and immune complexes. The antibody deficiency, defects of cell-mediated immunity, disorders of neutrophil function, and overview of autoimmune disease are also covered. This publication is recommended for junior doctors in training, but is also valuable to senior clinical investigators in all disciplines who find themselves reluctantly obliged to acquire the rudiments of immunology in order to interpret important developments in their own fields.

Main topics covered: B-Cell Development; Immunoglobulin Gene Rearrangement; Multiple Myeloma, Plasmactomas; Lymphomas: B-CLL, Folli- cular Lymphomas BCL-2, BCL-1; Lymphomas: EBV, AIDS Associa- ted Lymphomas; Oncogenes and Transcriptional Factors (text to follow)

Whether you are following a problem-based, an integrated, or a more traditional medical course, clinical biochemistry is often viewed as one of the more challenging subjects to grasp. What you need is a single resource that not only explains the biochemical underpinnings of metabolic medicine, but also integrates laboratory findings with clinical p

During the last decade facilities for treating patients with end-stage renal failure have expanded in all Westernized countries. Partly as a consequence, interest has been stimulated in many multisystem dis eases which may progress to chronic renal failure. Some of these diseases such as diabetes mellitus are common but still have con troversial aspects to their investigation and management. Others such as lupus nephritis are relatively rare but respond well to recent advances in therapy. In addition to diabetes mellitus and lupus nephritis this volume has chapters on multiple myeloma and Henoch-Schonlein purpura. All the chapters have been written by ackl10wiedged experts who have emphasized the practical aspects of patient management. The infor mation contained in this volume should thus prove of interest not only to nephrologists but to all practising clinicians. VII ABOUT THE EDITOR Professor Graeme R.D. Catto is Professor in Medicine and Thera peutics at the University of Aberdeen and Honorary Consultant Physician/Nephrologist to the Grampian Health Board. His current interest in transplant immunology was stimulated as a Harkness Fellow at Harvard Medical School and the Peter Bent Brighton Hos pital, Boston, USA. He is a member of many medical societies includ ing the Association of Physicians of Great Britain and Ireland, the Renal Association and the Transplantation Society. He has published widely on transplant and reproductive immunology, calcium metab olism and general nephrology.

Principles of Bone X-Ray Diagnosis follows the method set by Principles of Chest X-ray Diagnosis (Simon, 1956) in placing more value in the grouping of x-ray material according to the type of x-ray shadow rather than the clinical disease label. Biochemical and hematological values quoted throughout the book, especially in the captions to figures, are all from the Department of Pathology, St. Bartholomew's Hospital. This book is organized into 12 chapters. Much of the original text has been used in this third edition, though some changes of order have been made to give a more logical approach to the description of the bone changes seen in various diseases. A chapter on widespread and regional reduction in bone density has been completely rewritten. This volume provides radiographs to illustrate every condition described. These radiographs were selected to illustrate the principles of bone x-ray diagnosis rather than to make a complete catalogue of all the conditions referred. This book will be of interest to persons dealing with studies on the diagnostic value of bone x-ray.

The book presents a comprehensive overview of the various disease processes affecting the chest and related abnormalities. It discusses biopsy and bronchography, as well as a variety of imaging techniques including radiography, fluoroscopy, tomography, and ultrasound.

Haematological Oncology serves as a regular forum for the evaluation and dissemination of new information in this field and the topics selected for review range from basic science to clinical applications. The papers in Volume 3 cover the epidemiology of lymphoma; viral etiology of Hodgkin disease; cytogenetics of ALL; fungal infection; peripheral blood stem cell transplantation; conventional and aggressive treatment of myloma; and the laboratory aspects of myclodysplasia and differentiation therapy. This up-to-date review of the current state of research in hematological oncology will be an important source of information and knowledge.

This book is intended as a practical bench manual phological abnormalities in renal diseases, and for the hospital pathologist who wishes to have where appropriate these have been illustrated. access to a simple informative account of renal Although the main emphasis is on the pathology, pathology, particularly for the interpretation of the relevant clinical aspects of the conditions cov percutaneous needle biopsy specimens. I n addition ered are included in recognition of the fact that we trust it will be valuable to physicians working renal disease is an area in which correlation of the in the field of renal disease, for whom the interpre clinical and histopathological findings is particularly tation of renal biopsy material is directly relevant to important in reaching an informed diagnosis. patient management. Whilst a comprehensive coverage more appro priate to a larger text has not been attempted, the Acknowledgements text has been planned to give an adequate account of the more important non-neoplastic disease pro We would like to thank the technical staff of the cesses and their pathological appearances in the Histopathology Laboratories of The London Hos kidney. Points of difficulty in interpretation and dif pital Medical College, The Hospital for Sick Chil ferential diagnosis are covered both in the text and in dren, Great Ormond Street, and Guy's Hospital the illustrations.