Over the last 18 years, there have been many advances in the field of intraoperative monitoring. This new edition of Neurophysiology in Neurosurgery: A Modern Approach provides updates on the original techniques, as well as other more recent methodologies that may either prove beneficial or are commonly used in neuromonitoring. The purpose of this book is to describe the integration of neuromonitoring with surgical procedures. Each methodology is discussed in detail as well as chapters describing how those methodologies are applied to multiple surgical procedures and the evidence used to support those uses. The second edition features a surgical procedure section, which focuses on specific surgical procedures and the type of monitoring used during these procedures. The original chapters have been updated, expanded, and the structure modified to ensure the book is beneficial to both physiologists and surgeons. This book is written for neurosurgeons, neurophysiologists, neurologists, anesthesiologists, interventional neuroradiologists, orthopedic surgeons, and plastic surgeons. - Provides a valuable educational tool that describes the theoretical and practical aspects of intraoperative monitoring through example - Presents in-depth descriptions of the most advanced techniques in intraoperative neurophysiological monitoring and mapping - Features a surgical procedures section that focuses on specific surgical procedures and the type of monitoring used during these procedures

This book includes a valuable and extensive bibliography with historical introduction on pages 3-44. It is a detailed study of the physiology of skeletal muscle.

A Physiological Approach to Clinical Neurology deals with the mechanism of various neurological symptoms and signs in terms of disordered physiology. Topics covered by this book include pain and other sensations; weakness; the tendon jerk and the stretch reflex; and disordered control of motor neurons. The disorders of basal ganglia and cerebellum are also considered, along with consciousness and unconsciousness; the mechanism of epilepsy; and the relationship between brain and mind. This book is comprised of 11 chapters and begins by introducing the reader to the clinical analysis of sensory and motor disorders. The discussion then turns to the perception of pain and other kinds of sensation; the clinical approach to the problem of weakness; and the clinical significance of the tendon jerk. In the chapters that follow, appraisal of a neurophysiological thought is applied to common neurological disorders such as Parkinson's disease, hemiballismus, epilepsy, and developmental anomalies like platybasia. The last chapter explores the phenomena of mind and its connection to the brain as well as its influence on the body, paying particular attention to perception, memory, and emotion. This monograph is intended for those who are proceeding into the clinical years of a medical course, to those who are studying for senior qualifications in internal medicine or neurology, and to those who are merely curious about the cause of neurological phenomena that they observe daily in their patients.

Studies of human movement have proliferated in recent years, and there have been many studies of spinal pathways in humans, their role in movement, and their dysfunction in neurological disorders. This comprehensive reference surveys the literature related to the control of spinal cord circuits in human subjects, showing how they can be studied, their role in normal movement, and how they malfunction in disease states. Chapters are highly illustrated and consistently organised, reviewing, for each pathway, the experimental background, methodology, organisation and control, role during motor tasks, and changes in patients with CNS lesions. Each chapter concludes with a helpful resume that can be used independently of the main text to provide practical guidance for clinical studies. This will be essential reading for research workers and clinicians involved in the study, treatment and rehabilitation of movement disorders.

In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg

Biomechanics and Motor Control: Defining Central Concepts provides a thorough update to the rapidly evolving fields of biomechanics of human motion and motor control with research published in biology, psychology, physics, medicine, physical therapy, robotics, and engineering consistently breaking new ground. This book clarifies the meaning of the most frequently used terms, and consists of four parts, with part one covering biomechanical concepts, including joint torques, stiffness and stiffness-like measures, viscosity, damping and impedance, and mechanical work and energy. Other sections deal with neurophysiological concepts used in motor control, such as muscle tone, reflex, pre-programmed reactions, efferent copy, and central pattern generator, and central motor control concepts, including redundancy and abundance, synergy, equilibrium-point hypothesis, and motor program, and posture and prehension from the field of motor behavior. The book is organized to cover smaller concepts within the context of larger concepts. For example, internal models are covered in the chapter on motor programs. Major concepts are not only defined, but given context as to how research came to use the term in this manner. - Presents a unified approach to an interdisciplinary, fragmented area - Defines key terms for understanding - Identifies key theories, concepts, and applications across theoretical perspectives - Provides historical context for definitions and theory evolution

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This book includes a valuable and extensive bibliography with historical introduction on pages 3-44. It is a detailed study of the physiology of skeletal muscle.

Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently occurring giant migrating contractions (GMCs) produce mass movements. Tonic contractions aid RPCs in their motor function. The spatiotemporal patterns of these contractions differ markedly. The amplitude and distance of propagation of a GMC are several-fold larger than those of an RPC. The enteric neurons and smooth muscle cells are the core regulators of all three types of contractions. The regulation of contractions by these mechanisms is modifiable by extrinsic factors: CNS, autonomic neurons, hormones, inflammatory mediators, and stress mediators. Only the GMCs produce descending inhibition, which accommodates the large bolus being propelled without increasing muscle tone. The strong compression of the colon wall generates afferent signals that are below nociceptive threshold in healthy subjects. However, these signals become nociceptive; if the amplitudes of GMCs increase, afferent nerves become hypersensitive, or descending inhibition is impaired. The GMCs also provide the force for rapid propulsion of feces and descending inhibition to relax the internal anal sphincter during defecation. The dysregulation of GMCs is a major factor in colonic motility disorders: irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and diverticular disease (DD). Frequent mass movements by GMCs cause diarrhea in diarrhea predominant IBS, IBD, and DD, while a decrease in the frequency of GMCs causes constipation. The GMCs generate the afferent signals for intermittent short-lived episodes of abdominal cramping in these disorders. Epigenetic dysregulation due to adverse events in early life is one of the major factors in generating the symptoms of IBS in adulthood.