This edited volume provides insights into and tools for the modeling, analysis, optimization, and control of large-scale networks in the life sciences and in engineering. Large-scale systems are often the result of networked interactions between a large number of subsystems, and their analysis and control are becoming increasingly important. The chapters of this book present the basic concepts and theoretical foundations of network theory and discuss its applications in different scientific areas such as biochemical reactions, chemical production processes, systems biology, electrical circuits, and mobile agents. The aim is to identify common concepts, to understand the underlying mathematical ideas, and to inspire discussions across the borders of the various disciplines. The book originates from the interdisciplinary summer school “Large Scale Networks in Engineering and Life Sciences” hosted by the International Max Planck Research School Magdeburg, September 26-30, 2011, and will therefore be of interest to mathematicians, engineers, physicists, biologists, chemists, and anyone involved in the network sciences. In particular, due to their introductory nature the chapters can serve individually or as a whole as the basis of graduate courses and seminars, future summer schools, or as reference material for practitioners in the network sciences.

This book offers a rigorous analysis of the achievements in the field of traffic control in large networks, oriented on two main aspects: the self-similarity in traffic behaviour and the scale-free characteristic of a complex network. Additionally, the authors propose a new insight in understanding the inner nature of things, and the cause-and-effect based on the identification of relationships and behaviours within a model, which is based on the study of the influence of the topological characteristics of a network upon the traffic behaviour. The effects of this influence are then discussed in order to find new solutions for traffic monitoring and diagnosis and also for traffic anomalies prediction. Although these concepts are illustrated using highly accurate, highly aggregated packet traces collected on backbone Internet links, the results of the analysis can be applied for any complex network whose traffic processes exhibit asymptotic self-similarity, perceived as an adaptability of traffic in networks. However, the problem with self-similar models is that they are computationally complex. Their fitting procedure is very time-consuming, while their parameters cannot be estimated based on the on-line measurements. In this aim, the main objective of this book is to discuss the problem of traffic prediction in the presence of self-similarity and particularly to offer a possibility to forecast future traffic variations and to predict network performance as precisely as possible, based on the measured traffic history.

This book is the culmination of three years of research effort on a multidisciplinary project in which physicists, mathematicians, computer scientists and social scientists worked together to arrive at a unifying picture of complex networks. The contributed chapters form a reference for the various problems in data analysis visualization and modeling of complex networks.

This book addresses a number of questions from the perspective of complex systems: How can we quantitatively understand the life phenomena? How can we model life systems as complex bio-molecular networks? Are there any methods to clarify the relationships among the structures, dynamics and functions of bio-molecular networks? How can we statistically analyse large-scale bio-molecular networks? Focusing on the modeling and analysis of bio-molecular networks, the book presents various sophisticated mathematical and statistical approaches. The life system can be described using various levels of bio-molecular networks, including gene regulatory networks, and protein-protein interaction networks. It first provides an overview of approaches to reconstruct various bio-molecular networks, and then discusses the modeling and dynamical analysis of simple genetic circuits, coupled genetic circuits, middle-sized and large-scale biological networks, clarifying the relationships between the structures, dynamics and functions of the networks covered. In the context of large-scale bio-molecular networks, it introduces a number of statistical methods for exploring important bioinformatics applications, including the identification of significant bio-molecules for network medicine and genetic engineering. Lastly, the book describes various state-of-art statistical methods for analysing omics data generated by high-throughput sequencing. This book is a valuable resource for readers interested in applying systems biology, dynamical systems or complex networks to explore the truth of nature.

Large-Scale Simulation: Models, Algorithms, and Applications gives you firsthand insight on the latest advances in large-scale simulation techniques. Most of the research results are drawn from the authors’ papers in top-tier, peer-reviewed, scientific conference proceedings and journals. The first part of the book presents the fundamentals of large-scale simulation, including high-level architecture and runtime infrastructure. The second part covers middleware and software architecture for large-scale simulations, such as decoupled federate architecture, fault tolerant mechanisms, grid-enabled simulation, and federation communities. In the third part, the authors explore mechanisms—such as simulation cloning methods and algorithms—that support quick evaluation of alternative scenarios. The final part describes how distributed computing technologies and many-core architecture are used to study social phenomena. Reflecting the latest research in the field, this book guides you in using and further researching advanced models and algorithms for large-scale distributed simulation. These simulation tools will help you gain insight into large-scale systems across many disciplines.

This book offers a rigorous analysis of the achievements in the field of traffic control in large networks, oriented on two main aspects: the self-similarity in traffic behaviour and the scale-free characteristic of a complex network. Additionally, the authors propose a new insight in understanding the inner nature of things, and the cause-and-effect based on the identification of relationships and behaviours within a model, which is based on the study of the influence of the topological characteristics of a network upon the traffic behaviour. The effects of this influence are then discussed in order to find new solutions for traffic monitoring and diagnosis and also for traffic anomalies prediction. Although these concepts are illustrated using highly accurate, highly aggregated packet traces collected on backbone Internet links, the results of the analysis can be applied for any complex network whose traffic processes exhibit asymptotic self-similarity, perceived as an adaptability of traffic in networks. However, the problem with self-similar models is that they are computationally complex. Their fitting procedure is very time-consuming, while their parameters cannot be estimated based on the on-line measurements. In this aim, the main objective of this book is to discuss the problem of traffic prediction in the presence of self-similarity and particularly to offer a possibility to forecast future traffic variations and to predict network performance as precisely as possible, based on the measured traffic history.