This book summarizes the most advanced technical aspects covering all steps for a thorough application of microarrays to inflammation topics – from sample generation to data analysis. In addition selected examples of successful applications of microarrays in major fields of inflammation research are presented. The book will help a researcher or clinician to plan, perform and analyze or to critically review microarray experiments related to inflammation research.

This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice. The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, proteomics and metabonomics) that have led to biomarker discovery and places these biomarkers within a clinical context to help understand their utility in clinical practice. This book will be of use to clinicians who have an interest in using biomarkers in clinical practice as well as clinician researchers and scientists involved in the biomarker research pipeline. The author team comprises experts from around the world in order to bring together the literature in an effort to inform clinicians and researchers about the current state-of-the art in biomarker discovery. It is intended to assist future research efforts and indicate how biomarkers might be best applied to clinical practice both at present and in the future.

This book presents practical approaches for the analysis of data from gene expression micro-arrays. It describes the conceptual and methodological underpinning for a statistical tool and its implementation in software. The book includes coverage of various packages that are part of the Bioconductor project and several related R tools. The materials presented cover a range of software tools designed for varied audiences.

Genomic signal processing (GSP) can be defined as the analysis, processing, and use of genomic signals to gain biological knowledge, and the translation of that knowledge into systems-based applications that can be used to diagnose and treat genetic diseases. Situated at the crossroads of engineering, biology, mathematics, statistics, and computer science, GSP requires the development of both nonlinear dynamical models that adequately represent genomic regulation, and diagnostic and therapeutic tools based on these models. This book facilitates these developments by providing rigorous mathematical definitions and propositions for the main elements of GSP and by paying attention to the validity of models relative to the data. Ilya Shmulevich and Edward Dougherty cover real-world situations and explain their mathematical modeling in relation to systems biology and systems medicine. Genomic Signal Processing makes a major contribution to computational biology, systems biology, and translational genomics by providing a self-contained explanation of the fundamental mathematical issues facing researchers in four areas: classification, clustering, network modeling, and network intervention.

Presenting the latest molecular diagnostic techniques in one comprehensive volume The molecular diagnostics landscape has changed dramatically since the last edition of Molecular Microbiology: Diagnostic Principles and Practice in 2011. With the spread of molecular testing and the development of new technologies and their opportunities, laboratory professionals and physicians more than ever need a resource to help them navigate this rapidly evolving field. Editors David Persing and Fred Tenover have brought together a team of experienced researchers and diagnosticians to update this third edition comprehensively, to present the latest developments in molecular diagnostics in the support of clinical care and of basic and clinical research, including next-generation sequencing and whole-genome analysis. These updates are provided in an easy-to-read format and supported by a broad range of practical advice, such as determining the appropriate type and quantity of a specimen, releasing and concentrating the targets, and eliminating inhibitors. Molecular Microbiology: Diagnostic Principles and Practice Presents the latest basic scientific theory underlying molecular diagnostics Offers tested and proven applications of molecular diagnostics for the diagnosis of infectious diseases, including point-of-care testing Illustrates and summarizes key concepts and techniques with detailed figures and tables Discusses emerging technologies, including the use of molecular typing methods for real-time tracking of infectious outbreaks and antibiotic resistance Advises on the latest quality control and quality assurance measures Explores the increasing opportunities and capabilities of information technology Molecular Microbiology: Diagnostic Principles and Practice is a textbook for molecular diagnostics courses that can also be used by anyone involved with diagnostic test selection and interpretation. It is also a useful reference for laboratories and as a continuing education resource for physicians. If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow.

This book presents a comprehensive review of the inflammatory myopathies, including dermatomyositis, polymyositis, and inclusion body myositis. Representing the most up-to-date knowledge on this family of diseases, this book is the gold-standard in its field.

This thoroughly updated edition covers all clinical aspects of neuroinflammation. The latest developments in pathogenesis and advances in treatment are provided, along with an understanding of the immune system's role and interactions between the activated immune cells, cerebral endothelial cells, and other main components of the immune cascade. Cutting-edge and authoritative, this volume offers practitioners a valuable resource for research and clinical practice.

Nutrition plays a key role in prevention of cardiovascular disease, the leading cause of death worldwide. Diet influences a broad spectrum of cardiometabolic risk factors, notably a cluster including excess adiposity, dyslipidemia, impaired glucose metabolism and high blood pressure. In the face of the rapidly increasing incidence of obesity and diabetes, maintaining cardiometabolic health through adoption of a healthy lifestyle is a top public health priority. In this book, Nutrition and Cardiometabolic Health, international experts present state-of-the-art scholarly reviews of dietary and lifestyle effects on metabolic systems associated with cardiovascular health and disease. It covers a broad range of topics including biological and behavioral processes regulating food intake; lifestyle and surgical approaches to weight loss; nutritional considerations for optimal cardiometabolic health across the lifespan; the relationship of macronutrients, whole foods and dietary patterns to diabetes and cardiovascular disease; and diet as a modulator of gene expression, epigenetics and the gut microbiome and the relationship of these traits to disorders of metabolism. This book provides its readers with an authoritative view of the present state of knowledge of dietary effects on cardiometabolic health and will be of interest to nutrition and healthcare professionals alike.

Biological Mechanisms of Tooth Movement This new edition continues to be an authoritative reference to the scientific foundations underpinning clinical orthodontics The newly and thoroughly revised Third Edition of Biological Mechanisms of Tooth Movement delivers a comprehensive reference for orthodontic trainees and specialists. It is fully updated to include new chapters on personalized orthodontics as well as the inflammatory process occurring in the dental and paradental tissues. It is heavily illustrated throughout, making it easier for readers to understand and retain the information discussed within. The topics covered range from bone biology, the effects of mechanical loading on tissues and cells, genetics, tissue remodeling, and the effects of diet, drugs, and systemic diseases. The Third Edition of Biological Mechanisms of Tooth Movement features seven sections that cover subjects such as: The development of biological concepts in orthodontics, including the cellular and molecular biology behind orthodontic tooth movement Mechanics meets biology, including the effects of mechanical loading on hard and soft tissues and cells, and biological reactions to temporary anchorage devices Inflammation and orthodontics, including markers for tissue remodeling in the gingival crevicular fluid and saliva Personalized diagnosis and treatment based on genomic criteria, including the genetic influences on orthodontic tooth movement Rapid orthodontics, including methods to accelerate or decelerate orthodontic tooth movement Perfect for residents and PhD students of orthodontic and periodontal programs, Biological Mechanisms of Tooth Movement is also useful to academics, clinicians, bone biologists, and researchers with an interest in the mechanics and biology of tooth movement.

This is the second edition of a well-received book that reflects the state of the art in cancer medical therapies and their side-effects, including immunotherapy and chemotherapeutic drugs. All chapters have been fully updated to include all the latest progress in drug discovery such as targeted therapies for each cancer type. From issues such as preservation of fertility to antiemetic therapy the book provides a very comprehensive overview of the field. The book includes a new chapter on immuno-oncology drugs. Organised by organ system, it lists the toxicity, side-effects and measures of prevention pertaining to each type of drug used in cancer therapy. The most dangerous side-effects are priority so as to alert the reader to their importance. Designed for quick reference in the clinical setting this book is primarily aimed at established medical oncologists but will also appeal to junior doctors, trainees, pharmacists and nurses.