Metabolism of Drugs and Other Xenobiotics

Metabolism of Drugs and Other Xenobiotics
Author :
Publisher : John Wiley & Sons
Total Pages : 755
Release :
ISBN-10 : 9783527329038
ISBN-13 : 352732903X
Rating : 4/5 (38 Downloads)

Synopsis Metabolism of Drugs and Other Xenobiotics by : Pavel Anzenbacher

A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.

Enzyme Systems that Metabolise Drugs and Other Xenobiotics

Enzyme Systems that Metabolise Drugs and Other Xenobiotics
Author :
Publisher : John Wiley & Sons
Total Pages : 600
Release :
ISBN-10 : UOM:39015053755693
ISBN-13 :
Rating : 4/5 (93 Downloads)

Synopsis Enzyme Systems that Metabolise Drugs and Other Xenobiotics by : Costas Ioannides

This reference work focuses on the enzyme systems that participate in the metabolism of chemicals and other xenobiotics, with emphasis being placed on drug metabolism. Each chapter focuses on a specific enzyme system.

Cytochromes P450

Cytochromes P450
Author :
Publisher : Royal Society of Chemistry
Total Pages : 538
Release :
ISBN-10 : 9781847558428
ISBN-13 : 1847558429
Rating : 4/5 (28 Downloads)

Synopsis Cytochromes P450 by : Costas Ioannides

During half a century, cytochrome P450 in its original uniqueness as an optically "wrong" cytochrome has attracted many investigators, who have contributed to the unveiling of a bewildering multiplicity of biologically important functions of the, by now very large, superfamily of cytochrome P 450 enzymes. With its discovery in 1958 and with the advent of more refined spectroscopic methodologies, through the double wavelength spectrophotometry, the mysterious enzyme system began to reveal its secrets in a swift stream of investigative successes. As one of the most extensively studied enzyme systems worldwide the interest in cytochromes P450 very much reflects its importance in the elimination of drugs and other chemicals from the body and its role in chemical toxicity and in the aetiology of diseases such as cancer. There has been significant progress in research in this area in recent years and current books on this subject are now out of date. This much needed, new, fully up-to-date publication fills this gap and emphasises the new relevant topics that have emerged during the last decade in an easily accessible manner. The enzyme system, cytochromes P450, comprises a number of families/subfamilies, and the focus of the book is to deal with each individually, furnishing information directly relevant to scientists involved in the development of chemicals, in particular in the evaluation of their safety. The book has contributions from internationally respected scientists who are research-active in the relevant areas. The authors have made extensive use of figures and tables so that the reader can access the necessary information without always having to read the text. In addition, a very extensive, user-friendly index is a unique hallmark of the book. Part A of this monograph introduces the reader to the current knowledge of the evolutionary development of cytochrome P450 structure and function. Furthermore, it deals with the role of this enzyme in the formation of reactive intermediates. The shrewd and extensive utilisation of the molecular biology methodology very rapidly led to a vast body of enzymes calling for a classification of the plethora of different cytochromes P450 (the superfamily) into families and subfamilies. This is aptly exemplified by the ten chapters in Part B of this book, dealing with ten subfamilies and two families of cytochrome P450. Part C offers an insight into another aspect of cytochrome P450 research, namely its regulation through receptor-mediated stimuli - as opposed to enzyme induction or inhibition. The final chapter translates the current data on one of several drug metabolising systems into clinical application and highlights the role of cytochromes P450 in the treatment of neoplastic growth. The book deals extensively with each family/subfamily of the cytochromes P450 that contribute to the metabolism of xenobiotics. Essential and invaluable information is provided for the industrial research scientist working with fine chemicals, and especially those in the pharmaceutical industry, dealing with the safety evaluation of chemicals or being involved in the study of their metabolism, pharmacokinetics and toxicological properties. It should also prove of interest to Regulators concerned with the safety evaluation of chemicals, research pharmacologists and toxicologists, and postgraduate students studying drug metabolism and toxicology at an advanced level.

Biochemistry of Redox Reactions

Biochemistry of Redox Reactions
Author :
Publisher : Academic Press
Total Pages : 520
Release :
ISBN-10 : UOM:39015033951826
ISBN-13 :
Rating : 4/5 (26 Downloads)

Synopsis Biochemistry of Redox Reactions by : Bernard Testa

Surpassing the 1976 book by Testa and Jenner, Drug Metabolism: Chemical and Biochemical Aspects (Dekker), this informative, up-to-date text includes the following features, unavailable elsewhere: First in a set of books to provide a comprehensive coverage of drug metabolism; Opening chapter provides a general introduction to the complete set of books; Other chapters cover reaction mechanisms, catalytic cycles, regio- and stereoselectivities, types of substrates, reactivity of intermediates, and drug-enzyme interactions; Extensive detailed diagrams of reaction pathways and chemical structures * First in a set of books providing a comprehensive coverage of drug metabolism * Opening chapter provides a general introduction to the complete set of books * Other chapters cover reaction mechanisms, catalytic cycles, regio and stereoselectivities, types of substrates, reactivity of intermediates and drug-enzyme interactions * Extensive detailed diagrams of reaction pathways and chemical structures

Hydrolysis in Drug and Prodrug Metabolism

Hydrolysis in Drug and Prodrug Metabolism
Author :
Publisher : John Wiley & Sons
Total Pages : 808
Release :
ISBN-10 : 390639025X
ISBN-13 : 9783906390253
Rating : 4/5 (5X Downloads)

Synopsis Hydrolysis in Drug and Prodrug Metabolism by : Bernard Testa

Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.

Metabolism of Xenobiotics

Metabolism of Xenobiotics
Author :
Publisher : Taylor & Francis Group
Total Pages : 400
Release :
ISBN-10 : UOM:39015012582121
ISBN-13 :
Rating : 4/5 (21 Downloads)

Synopsis Metabolism of Xenobiotics by : International Society for the Study of Xenobiotics

Applied Chemoinformatics

Applied Chemoinformatics
Author :
Publisher : John Wiley & Sons
Total Pages : 660
Release :
ISBN-10 : 9783527342013
ISBN-13 : 352734201X
Rating : 4/5 (13 Downloads)

Synopsis Applied Chemoinformatics by : Thomas Engel

Edited by world-famous pioneers in chemoinformatics, this is a clearly structured and applications-oriented approach to the topic, providing up-to-date and focused information on the wide range of applications in this exciting field. The authors explain methods and software tools, such that the reader will not only learn the basics but also how to use the different software packages available. Experts describe applications in such different fields as structure-spectra correlations, virtual screening, prediction of active sites, library design, the prediction of the properties of chemicals, the development of new cosmetics products, quality control in food, the design of new materials with improved properties, toxicity modeling, assessment of the risk of chemicals, and the control of chemical processes. The book is aimed at advanced students as well as lectures but also at scientists that want to learn how chemoinformatics could assist them in solving their daily scientific tasks. Together with the corresponding textbook Chemoinformatics - Basic Concepts and Methods (ISBN 9783527331093) on the fundamentals of chemoinformatics readers will have a comprehensive overview of the field.

Biotransformation and Metabolite Elucidation of Xenobiotics

Biotransformation and Metabolite Elucidation of Xenobiotics
Author :
Publisher : John Wiley & Sons
Total Pages : 224
Release :
ISBN-10 : 9781118097779
ISBN-13 : 1118097777
Rating : 4/5 (79 Downloads)

Synopsis Biotransformation and Metabolite Elucidation of Xenobiotics by : Ala F. Nassar

The goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for identifying and characterizing metabolites, FDA guidelines, and case studies on how to improve the decision-making process in structural modification of drug candidates to reduce toxicity. The book consists of 8 chapters; it first provides an introduction on biotransformation of xenobiotics, and then presents modern approaches and strategies for dealing with metabolite characterization, using tools such as LC-MS, H-D exchange, stable isotopes LC-MS-NMR, and radiolabeled compounds. Also, strategies for dealing with reactive intermediates in drug discovery and development are presented as well as case studies on improving the decision-making process in the structural modification of drug candidates. The last chapter discusses the regulatory perspectives of safety testing of drug metabolites and why, how, and when to test their safety.

Clarke's Isolation and Identification of Drugs in Pharmaceuticals, Body Fluids, and Post-mortem Material

Clarke's Isolation and Identification of Drugs in Pharmaceuticals, Body Fluids, and Post-mortem Material
Author :
Publisher :
Total Pages : 1258
Release :
ISBN-10 : UOM:39015045566976
ISBN-13 :
Rating : 4/5 (76 Downloads)

Synopsis Clarke's Isolation and Identification of Drugs in Pharmaceuticals, Body Fluids, and Post-mortem Material by : Eustace George Coverley Clarke

Provides the means to identify and quantify drugs and other toxic substances in situations of overdose or poisoning and to interpret analytical results. Includes an analysis of toxic metals and pesticides.

Handbook of Forensic Medicine

Handbook of Forensic Medicine
Author :
Publisher : John Wiley & Sons
Total Pages : 1312
Release :
ISBN-10 : 9781118570623
ISBN-13 : 1118570626
Rating : 4/5 (23 Downloads)

Synopsis Handbook of Forensic Medicine by : Burkhard Madea

Forensic Medicine encompasses all areas in which medicine and law interact. This book covers diverse aspects of forensic medicine including forensic pathology, traumatology and violent death, sudden and unexpected death, clinical forensic medicine, toxicology, traffic medicine, identification, haemogenetics and medical law. A knowledge of all these subdisciplines is necessary in order to solve routine as well as more unusual cases. Taking a comprehensive approach the book m.oves beyond a focus on forensic pathology to include clinical forensic medicine and forensic toxicology. All aspects of forensic medicine are covered to meet the specialist needs of daily casework. Aspects of routine analysis and quality control are addressed in each chapter. The book provides coverage of the latest developments in forensic molecular biology, forensic toxicology, molecular pathology and immunohistochemistry. A must-have reference for every specialist in the field this book is set to become the bench-mark for the international forensic medical community.