This book provides an overview of emerging CSF management systems that filter or clear cerebrospinal fluid (CSF) as a therapeutic approach for several CNS conditions. While the term "liquorpheresis" most accurately refers to extracorporeal procedures that filter CSF (similar to plasmapheresis), this book covers any method based on devices that -either alone or in combination with drugs- can clear CSF or enhance its turnover, which in turn dilutes toxins. The book begins with an overview of CSF anatomy and physiology, followed by a discussion of the role of CSF clearance and flow dysfunction in various CNS conditions. The next section describes the different CSF management systems and procedures that are currently available or under development. The book then reviews the potential applications of these systems for treating subarachnoid hemorrhage, CNS infections, meningeal carcinomatosis, autoimmune encephalitis, polyradiculomyelitis, and neurodegenerative diseases. Finally, a chapter discusses future advances in liquorpheresis systems and applications. This book is intended for clinicians, neuro-researchers, academics, and students who are interested in the development and application of CSF management systems. It is also relevant to the medical device industry, particularly those that develop apheresis and CSF management devices, and the drug-delivery industry.

Cerebrospinal Fluid and Arachnoid Space Volume 2: Pathology and Disorders is the first book devoted to the comprehensive clinical anatomy of the cerebrospinal fluid for neurosurgeons, neurologists, and neuroscientists. Knowledge of the cerebrospinal fluid (CSF) and the subarachnoid space is necessary for almost all fields of medicine. The book covers a wide swath of topics related to CSF with a focus on topics relevant to neuroscience specialists including researchers, neurologists, neurosurgeons, and neuroradiologists. Topics span from neuroanatomy, neurophysiology, CSF in different disease states and more. Various fresh and fixed cadaveric photographs helps readers obtain a better understanding of anatomy and complications related to CSF. - First comprehensive book devoted to clinical anatomy of cerebrospinal fluid and subarachnoid space - Edited by neuro-anatomists and neurosurgeons, giving it a multimodal perspective - Nerves and vessels color-coded to differentiate from other tissues

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

This critical care medicine book substantially differs from others due to the range of peculiarities that characterize it. Since it deals with acute patients in critical conditions, this is, as it were, a 'borderline'book,in the sense that it is intended for those, who, in their activity, need a continuous and in-depth interdisciplinary approach to optimize the quality of the treatments offered to critically-ill patients. This book helps to have a better understanding of the current limits of human intervention and aims at supplying updated guidelines; in particular, it is intended for those who, although having to guarantee continuity and top-quality therapies, must decide when and why the collaboration with and intervention by experts is necessary.

The API (Association of Physicians of India) Textbook of Medicine consists of 28 sections across two comprehensive volumes covering a wide range of medical disorders. Fully revised and with 1588 images, illustrations and tables, this new edition has many new chapters on topics including nanotechnology and nano-medicine, and clinical approach to key manifestations. Each section is dedicated to a different medical phenomenon, including clinical pharmacology, endocrinology, dermatology, infectious diseases and nutrition. Also included is online access to teaching modules for teachers and students, questions and answers, an atlas/image bank, echocardiography and video EEG and common medical procedures with voice over.

Though considerable amount of research, both pre-clinical and clinical, has been conducted during recent years, Amyotrophic Lateral Sclerosis (ALS) remains one of the mysterious diseases of the 21st century. Great efforts have been made to develop pathophysiological models and to clarify the underlying pathology, and with novel instruments in genetics and transgenic techniques, the aim for finding a durable cure comes into scope. On the other hand, most pharmacological trials failed to show a benefit for ALS patients. In this book, the reader will find a compilation of state-of-the-art reviews about the etiology, epidemiology, and pathophysiology of ALS, the molecular basis of disease progression and clinical manifestations, the genetics familial ALS, as well as novel diagnostic criteria in the field of electrophysiology. An overview over all relevant pharmacological trials in ALS patients is also included, while the book concludes with a discussion on current advances and future trends in ALS research.

Evidence-based, peer reviewed, best practice management guidelines for neurologists Diagnosis is only part of the puzzle. Effective treatment is what your patients really want. The European Federation of Neurological Societies has been publishing management guidelines in the European Journal of Neurology for many years. Developed by a consensus approach, using graded evidence, and then fully peer reviewed, these guidelines provide gold-standard, best-practice guidance to the treatment of neurological disorders. They help bridge the gap between what is done and what should be done for patients with neurological disorders. The basic guidelines have been expanded with ‘Recommendations’ based on strong evidence and ‘Good Practice Points’ where only weaker evidence is available. The Guidelines in this volume cover: Investigation Major neurological diseases Neuromuscular diseases Infections Neurological problems Sleep disorders Rehabilitation The European Handbook of Neurological Management provides a thoroughly rounded and grounded approach to best-practice neurological management using evidence-based principles.

The Guillain-Barre syndrome (GBS) or Landry-Guillain-Barre-Strohl syndrome, also known as post-infectious polyneuropathy or acute idiopathic polyneuritis, is an acute acquired, frequently severe, monophasic autoimmune illness of the peripheral nervous system (PNS). GBS manifests itself with the clinical picture characterised by gait disturbance, pain, weakness, rapidly ascending symmetric flaccid muscle paralysis, areflexia with distal predominance (involving lower motor neuron), sensory disturbance, variable autonomic involvement, and increased cerebrospinal fluid protein without pleocytosis . Although GBS had previously been viewed as a unitary disorder with variations, it is today considered as a group of syndromes with several distinctive variants or subtypes. The aim of this book is to describe and discuss this disease that is not exactly rare but is almost the only inflammatory polyneuropathy and the most frequent cause of acute flaccid paralysis in general medical practice.

A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases