Every family has secrets; only some secrets are lethal. In Victoria Costello’s family mental illness had been given many names over at least four generations until this inherited conspiracy of silence finally endangered the youngest members of the family, her children. In this riveting story—part memoir, detective story, and scientific investigation—the author recounts how the mental unraveling of her seventeen-year-old son Alex compelled her to look back into family history for clues to his condition. Eventually she tied Alex’s descent into hallucinations and months of shoeless wandering on the streets of Los Angeles to his great grandfather’s suicide on a New York City railroad track in 1913. But this insight brought no quick relief. Within two years of Alex’s diagnosis of paranoid schizophrenia, both she and her youngest son succumbed to two different mental disorders: major depression and anxiety disorder. Costello depicts her struggle to get the best possible mental health care for her sons and herself, treatment that ultimately brings each of them to full recovery. In the process, she discovers new science that explains how clusters of mental illness traverse family generations. Artfully weaving the scientific into the personal, Costello takes a journey to the far reaches of neuroscience and reports back on the startling findings it is yielding about the complex interplay between genes and environment that drives mental illness, and what it now tells us about how parents can trump a lethal inheritance. She shares the results of long-term U.K. and European family studies identifying the earliest signs of mental illnesses that can be passed on from grandparents to parents and grandchildren. She tracks ongoing clinical trials to reverse the courses of these diseases through early intervention with the latest evidence-based treatments and offers brain-healthy choices individuals and families can make to prevent mental illness—freeing future generations to live healthier, happier lives.

On a rescue mission in a mysterious hidden realm, ex-fencing champion Ariel battles treacherous terrain, vicious elementals, and wraith-like demons who feed on fear and want her dead. To defeat the demons and free her mother, she must learn a secret esoteric wisdom to awaken the dormant but potentially explosive power of her mind.Walnut, a quirky old wise man, guides her across stone-strewn plains and wind-swept swamps, past deep ravines and quaint villages, and through a modern city enclosed in a transparent dome. Nick, the powerful Warrior who travels with them, proves a dangerous attraction. His feral energy hits her like a sledgehammer; sometimes it's bliss, but often it's pain. Can Ariel defeat the sadistic demon lord before he kills her and enslaves her mother? The stakes are high, death a real possibility. Fail now, and she fails humanity.

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Morrison (human genetics, University of Ulster, UK) and Spence (biomedical science, University of Ulster, UK) offer an accessible reference on the genetic disorders that surgeons can expect to meet in general surgical practice. Written in non-technical language, with a glossary, list of abbreviations, and color and b&w photos and medical images, the book supplies an introduction to the nomenclature and technology of molecular biology, and will be a useful starting point for those who wish to extend their knowledge. Annotation :2005 Book News, Inc., Portland, OR (booknews.com).

This gripping story of the doctors at the forefront of Alzheimer’s research and the courageous North Dakota family whose rare genetic code is helping to understand our most feared diseases is “excellent, accessible...A science text that reads like a mystery and treats its subjects with humanity and sympathy” (Library Journal, starred review). Every sixty-nine seconds, someone is diagnosed with Alzheimer’s disease. Of the top ten killers, it is the only disease for which there is no cure or treatment. For most people, there is nothing that they can do to fight back. But one family is doing all they can. The DeMoe family has the most devastating form of the disease that there is: early onset Alzheimer’s, an inherited genetic mutation that causes the disease in one hundred percent of cases, and has a fifty percent chance of being passed onto the next generation. Of the six DeMoe children whose father had it, five have inherited the gene; the sixth, daughter Karla, has inherited responsibility for all of them. But rather than give up in the face of such news, the DeMoes have agreed to spend their precious, abbreviated years as part of a worldwide study that could utterly change the landscape of Alzheimer’s research and offers the brightest hope for future treatments—and possibly a cure. Drawing from several years of in-depth research with this charming and upbeat family, journalist Niki Kapsambelis tells the story of Alzheimer’s through the humanizing lens of these ordinary people made extraordinary by both their terrible circumstances and their bravery. “A compelling narrative…and an educational and emotional chronicle” (Kirkus Reviews, starred review), their tale is intertwined with the dramatic narrative history of the disease, the cutting-edge research that brings us ever closer to a possible cure, and the accounts of the extraordinary doctors spearheading these groundbreaking studies. From the oil fields of North Dakota to the jungles of Colombia, this inspiring race against time redefines courage in the face of this most pervasive and mysterious disease.

The year is 2054 and humanity's genetic health is in the hands of the giant de Margham Corporation. Established by Maelgwen de Margham and her late husband, Saul, the Corporation supplies a universal gene therapy that avoids violation of the Marshall Dictat: the absolute prohibition on making inheritable changes in a person's genetic structure.

"A world of big bucks deals and off-the-record promises, the high-end auction industry is a game of the elite. After eight years in the American Furniture department at Christie's, Carolyn Everett is a rising star. The 29-year-old has just sold the most expensive piece of American furniture ever made and four months later, acquires the country's premiere private furniture collection. But one wrong decision and a scandal that rocks Christie's leaves Carolyn unemployed and broken. Desperate to piece her life back together, she leaves New York City to work in a tiny antique store in Newport, Rhode Island. At a small county auction, she comes across a piece of Middle Eastern pottery, which she purchases for twenty dollars on a hunch. The journey to find its original owner takes her from beau monde Newport to the historic town's United States Navy Base and into a relationship with notorious womanizer Marine Sergeant Tyler Ford, who claims the relic was a gift from his translator during the early days of the Iraq War. Tyler and Carolyn, from two different worlds, fall into a relationship of mystery and obsession, until the provenance of the art that brought them together comes under intense scrutiny. Did Tyler participate in the raid of the National Museum of Iraq? Will he face criminal charges? And does Carolyn really know the man she's fallen in love with?"--

Genetics accepts contributions that present the results of original research in genetics and related scientific disciplines.

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.