Searching for the key to save a world beyond hope. Tsutomu Nihei's sci-fi horror epic! In Tsutomu Nihei's nightmare vision of the future, the N5S virus has swept across the earth, turning most of the population into zombie-like drones. Zoichi Kanoe, an agent of Toa Heavy Industry, is humanity's last hope, and he's not even human! With the help of Fuyu, a digitized intelligence built into the computer system of his Heavy Dual Coil motorcycle, Zoichi's search for the key to salvation will take him on a journey across surreal landscapes and hurl him into battle against mind-bending evil. Prepare yourself for the ultimate trip--prepare yourself for the world of BIOMEGA. After capturing Eon Green, DRF forces are amassing around Toa Heavy Industry headquarters and have taken Dr. Kurokawa and his daughter into custody. Zoichi must attempt a rescue--Dr. Kurokawa's laboratory may yield critical information on Eon Green. Elsewhere, Toa Heavy Industry agent Nishu Mizunoe searches for Kozlov Grebnev and the secrets he knows about the DRF's research, origins and their apocalyptic plan for the entire human race!

While their fight against the Empire continues, Titania uses her sensing abilities to track King Kajiwan as he heads toward the forbidden place known as the Gosabyo. During their pursuit of Kajiwan, Titania and her allies encounter strange phenomenon and notice the Rebedoan army behaving in mysterious ways. The culprit turns out to be the terrifying power wielded by Emperor Nichiko Suou…

The Administration contacts Kyrii and Cibo, encouraging them to keep searching for the Net Terminal Gene which will stop the City from its intractable, chaotic growth. The Admin also warns them of the autonomous Safeguards, vicious entities that attempt to kill off any humans who access the Netsphere without the required Net Terminal Gene. Kyrii is attacked, and a group of humans who have settled on the outskirts of Toha Heavy Industries comes to his aid. Kyrii awakens with a newfound ability to read his surroundings, which allows him mere seconds to fend off an attacker lurking among the humans settlement. In the ensuing battle, Cibo makes a heavy sacrifice, but not before learning a startling truth about her traveling companion...

One of the manga world's most intriguing artist returns with a science-fiction tour de force which combines post apocolyptic action, modern sci-fi video game tropes and a traditional Japanese aesthetic in The Knights of Sidonia. Knights of Sidonia has been complied into a Master Edition featuring larger print, colored inserts and omibused volumes. Each Master's Edition volume compiles 2.5 volumes of the original Knights of Sidonia volumes.