Inherited White Matter Disorders And Their Mimics
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Author |
: |
Publisher |
: Elsevier |
Total Pages |
: 516 |
Release |
: 2024-09-23 |
ISBN-10 |
: 9780323992107 |
ISBN-13 |
: 0323992102 |
Rating |
: 4/5 (07 Downloads) |
Synopsis Inherited White Matter Disorders and Their Mimics by :
Inherited White Matter Disorders and Their Mimics, Volume 204 discusses where imaging abnormalities and pathology lie predominantly in the CNS white matter. Many acquired causes, such as multiple sclerosis, are readily diagnosed and familiar to the majority of neurologists. However, less common acquired causes and genetic disorders (the leukodystrophies and genetic leukoencephalopathies) often present a diagnostic challenge. The evaluation of patients with White matter disorders (WMDs) has evolved enormously in recent decades, due to advances in genetics, radiology, and the development of treatments for specific disorders. This book brings together WMD research, spanning basic science, molecular genetics, and clinical and radiological phenotyping. This volume presents both common WMDs and rare disorders according to their presentations or pathophysiology. Chapters lay out the clinical and radiological presentation of the disorder, followed by genetics and diagnostics, and finally discussion of pathophysiology and treatment. Chapter contain imaging, clinical pearls to diagnosis, and reference tables for genotype-phenotype correlation. For diagnostic work-up, easy to read algorithms are presented as well as clear guidance on indications for treatment, where applicable. - Includes common and rare white matter disorders (WMDs) - Summarizes advances in genetics, radiology, and treatments for WMDs - Provides clinical and radiological phenotyping - Contains imaging, diagnostic algorithms, and guidance on treatment
Author |
: Pankaj Sharma |
Publisher |
: Springer Nature |
Total Pages |
: 626 |
Release |
: |
ISBN-10 |
: 9783031417771 |
ISBN-13 |
: 3031417771 |
Rating |
: 4/5 (71 Downloads) |
Synopsis Stroke Genetics by : Pankaj Sharma
Author |
: Michel T. Torbey |
Publisher |
: Cambridge University Press |
Total Pages |
: 395 |
Release |
: 2013-07-18 |
ISBN-10 |
: 9781107634725 |
ISBN-13 |
: 1107634725 |
Rating |
: 4/5 (25 Downloads) |
Synopsis The Stroke Book by : Michel T. Torbey
An essential companion for busy professionals seeking to navigate stroke-related clinical situations successfully and make quick informed treatment decisions.
Author |
: Leonardo Pantoni |
Publisher |
: Cambridge University Press |
Total Pages |
: 375 |
Release |
: 2014-05 |
ISBN-10 |
: 9781107031661 |
ISBN-13 |
: 1107031664 |
Rating |
: 4/5 (61 Downloads) |
Synopsis Cerebral Small Vessel Disease by : Leonardo Pantoni
Up-to-date discussion of the etiology, diagnosis, treatment, and prevention of this common cause of stroke and cognitive impairment.
Author |
: |
Publisher |
: Elsevier |
Total Pages |
: 342 |
Release |
: 2024-10-02 |
ISBN-10 |
: 9780323901215 |
ISBN-13 |
: 0323901212 |
Rating |
: 4/5 (15 Downloads) |
Synopsis Cell and Gene Therapies for Neurologic Diseases by :
Cell and Gene Therapies for Neurologic Diseases, Volume 205 comprehensively covers the scientific background, translational efforts, clinical developments and registered biologics that have entered into clinical practice. Coverage includes types of therapies available and in development, and best practice uses for a variety of neurological disorders including Parkinson's, Huntington's, ALS, stroke, spinal cord RP, demyelination, and epilepsy. As the emergence of gene and cellular therapeutics has changed the clinical landscape for a variety of disorders, and is now ready to do so for neurological diseases, these therapeutic modalities currently complement, and may in time, supplant small molecule drugs. - Summarizes advances in cell and gene therapy for neurological diseases - Describes the therapies available and in development - Includes surgical, ethical, and manufacturing considerations - Identifies best practices for specific neurological diseases - Covers Huntington's, Parkinson's, ALS, Stroke, Demyelination, epilepsy, and more
Author |
: James F Bale Jr |
Publisher |
: CRC Press |
Total Pages |
: 353 |
Release |
: 2011-12-15 |
ISBN-10 |
: 9781840766028 |
ISBN-13 |
: 1840766026 |
Rating |
: 4/5 (28 Downloads) |
Synopsis Pediatric Neurology by : James F Bale Jr
Recognizing patterns of disease can be the first step to successful management of the child with a neurological problem; this is emphasized by the authors throughout the book. Their concise, precise account reflects the remarkable recent advances in pediatric neurology and related disciplines, while stressing the fundamentals of clinical examination and history taking in reaching an accurate diagnosis. The book begins with a detailed discussion of neurological examination techniques and the basic formulation of differential diagnoses and management, using neuroradiology, electrophysiology, cerebrospinal fluids, genetic and metabolic testing. The second section of the book follows a problem-based approach, just as diseases present in the real world. It employs practical, symptom- and sign-based strategies for virtually all conditions encountered by the practitioner. The final section on neurological emergencies recognizes that such conditions present first to someone other than a pediatric neurologist. This new color handbook is illustrated throughout by a wealth of top-quality clinical photos and imaging, and is of interest to pediatric neurologists, general pediatricians, primary care physicians and emergency physicians, in training and practice.
Author |
: Emmanuelle Waubant |
Publisher |
: Springer |
Total Pages |
: 338 |
Release |
: 2017-11-07 |
ISBN-10 |
: 9783319614076 |
ISBN-13 |
: 331961407X |
Rating |
: 4/5 (76 Downloads) |
Synopsis Pediatric Demyelinating Diseases of the Central Nervous System and Their Mimics by : Emmanuelle Waubant
This collection of pediatric clinical cases focus on multiple sclerosis, neuromyelitis optica, acute disseminated encephalomyelitis and mimics. Dedicated sections on diseases affecting the brain, brainstem, spinal cord and the optic nerve feature chapters that include the diagnostic work up, therapeutic management and case outcome. Typical and atypical presentations of various pediatric demyelinating diseases also emphasize therapy response and those that breakthrough on treatment. Filling a critical gap in the literature on inflammatory disorders of the central nervous system, all those that treat patients with these rare and challenging disorders will find this book extremely helpful for their daily clinical practice.
Author |
: Arie Perry |
Publisher |
: Elsevier Health Sciences |
Total Pages |
: 782 |
Release |
: 2017-10-16 |
ISBN-10 |
: 9780323508667 |
ISBN-13 |
: 0323508669 |
Rating |
: 4/5 (67 Downloads) |
Synopsis Practical Surgical Neuropathology: A Diagnostic Approach E-Book by : Arie Perry
Part of the in-depth and practical Pattern Recognition series, Practical Surgical Neuropathology, 2nd Edition, by Drs. Arie Perry and Daniel J. Brat, helps you arrive at an accurate CNS diagnosis by using a pattern-based approach. Leading diagnosticians in neuropathology guide you from a histological (and/or clinical, radiologic, and molecular) pattern, through the appropriate work-up, around the pitfalls, and to the best diagnosis. Almost 2,000 high-quality illustrations capture key neuropathological patterns for a full range of common and rare conditions, and a "visual index" at the beginning of the book directs you to the exact location of in-depth diagnostic guidance. - Instructive algorithms provide detailed guidance based on 8 major (scanning magnification) patterns and 20 minor (high magnification) patterns – helping you narrow the range of diagnostic possibilities. - A user-friendly design color-codes patterns to specific entities, and key points are summarized in tables, charts, and graphs so you can quickly and easily find what you are looking for. Sweeping content updates. Patterns call-outs throughout. The patterns described initially in the text will be better linked directly within the chapter, reinforcing the patterns for further understanding.
Author |
: Jacob Valk |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 734 |
Release |
: 2013-04-17 |
ISBN-10 |
: 9783662025680 |
ISBN-13 |
: 366202568X |
Rating |
: 4/5 (80 Downloads) |
Synopsis Magnetic Resonance of Myelin, Myelination, and Myelin Disorders by : Jacob Valk
Magnetic resonance imaging (MRI) is now considered the imaging modality of choice for the majority of disorders affecting the central nervous system. This is particularly true for gray and white matter disorders, thanks to the superb soft tis sue contrast in MRI which allows gray matter, unmyelinated, and myelinated white matter to be distinguished and their respective disorders identified. The pre sent book is devoted to the disorders of myelin and myelination. A growing amount of detailed in vivo information about myelin, myelination, and myelin dis orders has been derived both from MRI and from MR spectroscopy (MRS). This prompted us to review the clinical, laboratory, biochemical, and pathological data on this subject in order to integrate all available information and to provide im proved insights into normal and disordered myelin and myelination. We will show how the synthesis of all available information contributes to the interpretation of MR images. After a brief historical review about the increasing knowledge on myelin and my elin disorders, we propose a new classification of myelin disorders based on the subcellular localization of the enzymatic defects as far as the inborn errors of me tabolism are concerned. This classification serves as a guide throughout the book. All items of the classification will be discussed and, whenever relevant and possi ble, be illustrated by MR images.
Author |
: Sudha Seshadri |
Publisher |
: Oxford University Press |
Total Pages |
: 489 |
Release |
: 2016-03-07 |
ISBN-10 |
: 9780199337057 |
ISBN-13 |
: 0199337055 |
Rating |
: 4/5 (57 Downloads) |
Synopsis Risk Factors for Cerebrovascular Disease and Stroke by : Sudha Seshadri
Risk Factors for Cerebrovascular Disease and Stroke address the relationship of a wide variety of vascular risk factors in the spectrum of cerebrovascular diseases. An international group of professionals the forefront of research and education, provide their expertise about environmental and genetic determinants for cerebrovascular disease and stroke. The authors aim to provide information on developments of genetic, environmental and lifestyle-related risk factors of various subtypes of stroke, and MRI-markers of cerebrovascular disease. One in two men, and one in three women after the age of 40, will develop a stroke in their lifetime. The burden of cerebrovascular disease extends far beyond that of acute clinical events such as stroke, with "covert" vascular injury on brain MRI being highly prevalent in older community-dwelling persons. Therefore, improving our understanding of the risk factors for stroke and cerebrovascular disease is of paramount importance for improving prevention strategies. Secular trends in stroke epidemiology, risk factors, and intermediate markers (including carotid ultrasound, brain MRI and circulating biomarkers) are presented. Cutting edge information on genetic, environmental and lifestyle-related risk factors of various subtypes of stroke and MRI-markers of cerebrovascular diseases are displayed. This important book is an essential reference to physicians interested in more effective primary prevention of stroke.