A new tomographic imaging modality called magnetic particle imaging (MPI) has been proposed in 2005. Using the non-linear magnetization curve of specific nanoparticles, a detectable signal proportional to the concentration of these particles can be generated. For medical imaging the tracer material can be injected into the blood system. Due to fast image acquisition, not only morphological, but also functional imaging is possible. The feasibility of medical imaging with this technique could be demonstrated at real time imaging of a beating mouse heart. Spatial encoding is provided by superimposing dedicated external magnetic fields. For the resulting shape of this field a field free line has been proposed. This work presents the implementation of the MPI system with a discretely rotatable and dynamically translatable field free line.

Marlitt Erbe provides a detailed introduction into the young research field of Magnetic Particle Imaging (MPI) and field free line (FFL) imaging in particular. She derives a mathematical description of magnetic field generation for FFL imaging in MPI. To substantiate the simulation studies on magnetic FFL generation with a proof-of-concept, the author introduces the FFL field demonstrator, which provides the world’s first experimentally generated rotated and translated magnetic FFL field complying with the requirements for FFL reconstruction. Furthermore, she proposes a scanner design of considerably enhanced magnetic field quality and efficiency. The author discusses the influence of magnetic field quality optimization on the image quality achieved using efficient Radon-based reconstruction methods, which arise for a line detection scheme and based on this optimized design, presents a dynamic FFL scanner assembly.

This volume provides a comprehensive overview of recent developments in magnetic particle imaging (MPI), a novel imaging modality. Using various static and oscillating magnetic fields, and tracer materials made from iron oxide nanoparticles, MPI can perform background-free measurements of the particles’ local concentration. The method exploits the nonlinear remagnetization behavior of the particles and has the potential to surpass current methods for the detection of iron oxide in terms of sensitivity and spatiotemporal resolution. Starting from an introduction to the technology, the topics addressed include setting up an imaging device, assessment of image quality, development of new MPI tracer materials, and the first preclinical results. This is the first book to be published on magnetic particle imaging, and it will be an invaluable source of information for everyone with an interest in this exciting new modality.

Nanomedicine - the application of nanotechnology to human health - is a promising field of research at the interface of physical, chemical, biological, and medical science. Recent advances have made it possible to analyze biological systems at cellular and subcellular levels, offering numerous promising approaches to improve medical diagnosis and therapy. It is expected that nanomedicine will have a great impact especially on drug delivery and imaging. In this context, the development of targeted, highly specific nanoparticles is of pivotal importance. The results of these advances will offer personalized diagnostic tools and treatments in the future. Based on the 2nd Else Kröner-Fresenius-Symposium, this book presents a broad spectrum of topics ranging from nanoscale drug delivery/drug design to nanotoxicity and from diagnostics and imaging to therapeutic applications including antibody therapies. The contributions are authored by leading experts in the field and provide an excellent overview of the current knowledge in nanomedicine. Due to the interdisciplinary nature of the subject area this volume will be of special interest to physicians, biologists, chemists, engineers, and physicists as well as to students in the respective fields.

Magnetic Particle Imaging (MPI) is a novel medical imaging technology that is able to acquire the distribution of superparamagnetic iron oxide nanoparticles in real-time with high spatial and temporal resolution. Spatial encoding is realized by a magnetic field configuration generating a field-free point (FFP). Therefore, the FFP is moved through the field of view (FOV). However, at low particle concentrations the signal-to-noise ratio (SNR) decreases and therefore image quality worsens. An enhanced encoding scheme uses instead of the FFP the concept of a field-free line (FFL), whereby a gain of sensitivity of one order of magnitude can be realized. Simulation studies approximate power consumption to a minimum and improve field homogeneity with the result that fast Radon-based reconstruction techniques are feasible. On the basis of these studies, this book describes the manufacturing of an optimized scanner topology realizing an excellent field quality with the help of customized curved rectangular coils. Furthermore, the power loss is efficiently minimized.

In this second edition of Particle Accelerator Physics, Vol. 1, is mainly a reprint of the first edition without significant changes in content. The bibliography has been updated to include more recent progress in the field of particle accelerators. With the help of many observant readers a number of misprints and errors could be eliminated. The author would like to express his sincere appreciation to all those who have pointed out such shortcomings and wel comes such information and any other relevant information in the future. The author would also like to express his special thanks to the editor Dr. Helmut Lotsch and his staff for editorial as well as technical advice and support which contributed greatly to the broad acceptance of this text and made a second edition of both volumes necessary. Palo Alto, California Helmut Wiedemann November 1998 VII Preface to the First Edition The purpose of this textbook is to provide a comprehensive introduction into the physics of particle accelerators and particle beam dynamics. Parti cle accelerators have become important research tools in high energy physics as well as sources of incoherent and coherent radiation from the far infra red to hard x-rays for basic and applied research. During years of teaching accelerator physics it became clear that the single most annoying obstacle to get introduced into the field is the absence of a suitable textbook.

The discovery of uniform latex particles by polymer chemists of the Dow Chemical Company nearly 50 years ago opened up new exciting fields for scientists and physicians and established many new biomedical applications. Many in vitro diagnostic tests such as the latex agglutination tests, analytical cell and phagocytosis tests have since become rou tine. They were all developed on the basis of small particles bound to biological active molecules and fluorescent and radioactive markers. Further developments are ongoing, with the focus now shifted to applications of polymer particles in the controlled and di rected transport of drugs in living systems. Four important factors make microspheres interesting for in vivo applications: First, biocompatible polymer particles can be used to transport known amounts of drug and re lease them in a controlled fashion. Second, particles can be made of materials which bio degrade in living organisms without doing any harm. Third, particles with modified surfaces are able to avoid rapid capture by the reticuloendothelial system and therefore en hance their blood circulation time. Fourth, combining particles with specific molecules may allow organ-directed targeting.