Optical imaging in biomedicine provides pathophysiological information with high resolution, high speed, and minimal invasiveness. Endoscopy in particular has revolutionized healthcare diagnosis and treatment as well as biological research by offering visual access to otherwise unreachable remote tissues. However, existing endoscopic modalities face fundamental limitations in their designs that prohibit miniaturization to below a few millimeters in diameter, which would enable imaging through any natural or artificial lumen and thus unprecedented opportunities. This predicament and unmet medical needs such as deep-brain imaging, imaging-guided needle biopsy, and imaging-guided micro-surgery for new and scalable endoscope designs have motivated the concept of utilizing a single optical multimode fiber (MMF) as a stand-alone image conduit. MMF is fascinating as an optical waveguide attributed to its ultra-small footprint, high data throughput, low cost, and flexibility. Nevertheless, the mode mixing and dispersion effects inherent to MMF are technical barriers to its ability to relay clear images; optical propagation through a short length of MMF scrambles an image completely. The focus of this dissertation research is therefore to study waveguide physics of MMF and to innovate powerful computational methods as compensatory strategies that enable high fidelity imaging and sensing through the fiber: We developed numerical simulation toolboxes and experimental measurement systems to characterize bi-directional light transport through MMF; By modeling the light transmission through MMF and sample interaction with matrix operations, we demonstrated three-dimensional (3D) label-free multi-modal imaging based on computational reconstruction; To facilitate multi-spectral and broadband operations with MMF, we established a parametric dispersion model for efficient fiber calibration across a broad spectrum; The spatio-temporal modes within the MMF can be conveniently leveraged for depth sensing, where we created a high-resolution and long-range axial profiling system using MMF; Finally, we showed a proximal MMF calibration method for implementing flexible MMF-based endoscopes by exploiting the waveguide physics and numerical optimization.

This book sets out to build bridges between the domains of photonic device physics and neural networks, providing a comprehensive overview of the emerging field of "neuromorphic photonics." It includes a thorough discussion of evolution of neuromorphic photonics from the advent of fiber-optic neurons to today’s state-of-the-art integrated laser neurons, which are a current focus of international research. Neuromorphic Photonics explores candidate interconnection architectures and devices for integrated neuromorphic networks, along with key functionality such as learning. It is written at a level accessible to graduate students, while also intending to serve as a comprehensive reference for experts in the field.

Learn about the theory, techniques and applications of wavefront shaping in biomedical imaging using this unique text. With authoritative contributions from researchers who are defining the field, cutting-edge theory is combined with real-world practical examples, experimental data and the latest research trends to provide the first book-level treatment of the subject. It is suitable for both background reading and use in a course, with coverage of essential topics such as adaptive optical microscopy, deep tissue microscopy, time reversal and optical phase conjugation, and tomography. The latest images from the forefront of biomedical imaging are included, and full-colour versions are available in the eBook version. Researchers, practitioners and graduate students in optics, biophotonics, biomedical engineering, and biology who use biomedical imaging tools and are looking to advance their knowledge of the subject will find this an indispensable resource.

Mots-clés de l'auteur: Endoscopy ; Digital Phase Conjugation ; Fiber imaging ; Multimode fibers ; Multicore fibers ; Capillary waveguides ; Photoacoustic imaging ; Two-photon imaging ; Fluorescence imaging ; Saturated excitation microscopy.

Since the 3rd edition appeared, a fast evolution of the field has occurred. The fourth edition of this classic work provides an up-to-date account of the nonlinear phenomena occurring inside optical fibers. The contents include such important topics as self- and cross-phase modulation, stimulated Raman and Brillouin scattering, four-wave mixing, modulation instability, and optical solitons. Many new figures have been added to help illustrate the concepts discussed in the book. New to this edition are chapters on highly nonlinear fibers and and the novel nonlinear effects that have been observed in these fibers since 2000. Such a chapter should be of interest to people in the field of new wavelengths generation, which has potential application in medical diagnosis and treatments, spectroscopy, new wavelength lasers and light sources, etc. Continues to be industry bestseller providing unique source of comprehensive coverage on the subject of nonlinear fiber optics Fourth Edition is a completely up-to-date treatment of the nonlinear phenomena occurring inside optical fibers Includes 2 NEW CHAPTERS on the properties of highly nonlinear fibers and their novel nonlinear effects

This book is a MUST for everyone in and around the optics community! Fiber Optic Essentials provides professionals and students new to the field of fiber optics with a high-level knowledge of principles, theories and applications. This primer can also be used as a succinct overview of optics for those with some engineering and physics background. Individuals involved with optics in non-traditional capacities such as in marketing and legal departments will find this volume introduces basic concepts completely in an easy to read format. Casimer and Carolyn DeCusatis have provided a concise resource with compact chapters and minimal equations conveying this complex topic in a straightforward and clear-cut style. Included in this book are chapters on fibers, cables, connectors, transmitters, modulators, noise, and optical link design. Concluding this reference are three indispensable appendices covering extensive definitions, acronyms (including initials and commonly used slang), measurement conversions and physical constants. This author team has produced a book that has truly shed light on this difficult subject. - Comprehensively covers basic fiber optic 'facts' - Explains how optics relate to everyday life - Details fiber optic communication standards - Chapter included on medical applications - Timeline traces the history of optics with major milestones

Multi-Gigabit Transmission over Multimode Optical Fibre presents a system design approach to single-wavelength laser-based multimode optical fibre transmission systems, operating at multi-gigabit data rates. The first part of the book focuses on theoretical issues, covering close-form mathematical modelling of multimode fibre behaviour, with special attention on the impulse response. Part two presents a modular system modelling approach discussing its features, applications, and limitations. The author gives a detailed discussion of the Electronic Dispersion Compensator implemented using the Decision Feedback Equalizer technique. In addition, pioneering laboratory measurements of 10GbE over several hundreds of meters of legacy multimode fibres are presented in a systematic context for the first time. Multi-Gigabit Transmission over Multimode Optical Fibre: Provides a comprehensive guide to single-wavelength laser-based multimode optical fibre transmission systems, covering physics, systems and networks. Covers the theory, modelling and design criteria of high speed and multimode fibre optic communication systems. Explains waveguide theories, opto-electronic devices and system design. Offers a self-contained description of the optical pulse propagation theory. Discusses Electronic Dispersion Compensation technique as the most efficient mitigation of the multimode pulse dispersion. Multi-Gigabit Transmission over Multimode Optical Fibre will be an essential resource for R&D engineers and system designers, as well as advanced undergraduate and postgraduate students in the area of telecommunications and networking.

In this book, computational optical phase imaging techniques are presented along with Matlab codes that allow the reader to run their own simulations and gain a thorough understanding of the current state-of-the-art. The book focuses on modern applications of computational optical phase imaging in engineering measurements and biomedical imaging. Additionally, it discusses the future of computational optical phase imaging, especially in terms of system miniaturization and deep learning-based phase retrieval.