The relationship between testosterone and prostate cancer physiology resulted in a Nobel Prize almost 5 decades ago; scientists have been studying testosterone and its relationship to heart health, diabetes, bone density, and muscle development throughout the subsequent 50 years. Included in this issue is the clinical experience and research expertise of many of the leaders in this field.

The past decade has been marked by the acceleration of our understanding of the molecular biology of cancer. Simultaneously, there have been increasing exigencies to diagnose, treat and follow cancer patients more economically. Biomarkers represent the marriage of science and economics. Biomarkers offer the potential to increase the precision of diagnosis, prognosis, and surveillance of urological malignancies. This issue presents the cutting-edge advances of biomarker technology to urologic oncology.

In this issue of Urologic Clinics of North America, guest editor Dr. Kevin R. Loughlin brings his considerable expertise to the topic of Testosterone. With about 2 out of 10 men older than 60 years having low testosterone (American Urological Association), coupled with an aging population, this issue is an important resource for all urologists for effectively treating men and improving outcomes. It provides a current update on testosterone in men from top experts in the field, covering prostate cancer treatment, the use of anabolic steroids, hypogonadism, testosterone replacement, and more. - Contains 15 practice-oriented topics including current management and controversies surrounding andropause; testosterone and male sexual function; the interplay of testosterone and dihydrotestosterone in prostate cancer; and more. - Provides in-depth clinical reviews on testosterone, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue provides much needed updates since Dr. Sheinfeld’s issue published in 2007. Dr. Lin has assembled expert authors to provide clinicians with the full breadth of clinical updates on testicular cancer. New to this issue are articles on clinical outcomes, survivorship, and several articles on the management of Nonseminomatous Germ Cell Tumors.

The Guest Editors created a unique focus to the general topic of infectious diseases. They have focused on contemporary management of antibiotics used for procedures and infections. Articles are devoted to: Update on Antibiotic Prophylaxis for GU Procedures in Patients with Arificial Joint Replacement and Artifical Heart Valves; Asymptomatic Bacteriuria; Urinary Tract Infection and Bacteruria in Pregnancy; Resistance Patterns in Contemporary Antibiotics: ESBL and Beyond ; UTI and Neurogenic Bladder; Modern Guidelines for Skin and Bowel Prep for Open and Laparascopic GU Surgery; Work up of Pediatric Urinary Tract Infection; Pre Prostate Biopsy Rectal Culture and Post Biopsy Sepsis; Infection with Foreign Bodies: Mesh and Prostheses; Treatment of the Infected Stone; Sexually Transmitted Infections: Updated Guidelines and Treatment; Bacteruria/UTI in the Elderly; Treatement of Fungal Urinary Tract Infection; and STDs.

The Editor has assembled top experts to write authoritative reviews on the latest advances in the diagnosis and treatment of penile, urethral, and scrotal cancers. The issue stresses contrasting approaches and includes articles devoted to the following topics: radiation in primary urethral cancers; the role of node dissection; role of HPV in penile pre-neoplastic and carcinogenesis; advances in penile-sparing surgical approaches in the management of primary penile tumors; minimally invasive approaches to evaluating inguinal nodes in penile cancer patients; multimodal therapy in the management of advanced penile cancer; management of urethral cancer recurrences; Preneoplastic and primary scrotal cancer; and Advances in surgical reconstructive techniques in the management of penile, urethral, and scrotal cancer. The state-of-the article clinical and surgical details in this issue will keep urologists and other healthcare professionals current on the clinical management of these cancers.

In this issue of Endocrinology and Metabolism Clinics, guest editors Channa Jayasena and Shalender Bhasin bring their considerable expertise to the topic of Hypogonadism. - Provides in-depth reviews on the latest in Hypogonadism. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Benign prostatic hyperplasia and the resulting lower urinary tract symptoms is a major part of almost any urologist’s clinical practice. Due to the high prevalence of the disease in our aging population, new concepts and treatments are constantly entering the marketplace. Differences in patient preferences and desired outcomes require the practicing urologist to understand not only the pathophysiology of the disease but how specific treatments may be better suited for some patients and not others. This issue will address the current concepts and treatments available to urologists.

This encyclopedia volume covers the complete field of endocrine pathology – from Acidophil Stem Cell Adenoma to Waterhouse-Friderichsen syndrome. The alphabetically arranged entries, each of which provides a detailed description of a specific pathological disease pattern, allow readers to quickly and easily find the information they need.

Dr. Zhao has assembled the top experts in the field of urology to present state-of-the-art clinical reviews devoted to Male Urethral Reconstruction and the Management of Urethral Stricture Disease. The issue is divided into three sections, with focus on evlaluation and follow up, urethroplasty technique, and conditions affecting outcomes. Authors have specifically addressed the following topics: Definition of successful treatment and optimal follow up in urethral strictures; Cost analyses for evaluation and treatment of urethral strictures; Sexual dysfunction after urethroplasty; Endoscopic treatment of urethral stricture; Endoscopic treatment for urethral stenosis; Patient selection for urethroplasty technique: EPA vs Graft; Effect of graft location in urethroplasty; Non-transecting urethroplasty; Urethroplasty for panurethral urethral stricture; Use of alternative graft material in urethroplasty; Effect of Lichen Sclerosis on success of urethroplasty; Treatment of radiation induced urethral strictures; Effect of artificial urethral sphincters on strictures; Urethral strictures after transgender surgery; and Management of urethral strictures after hypospadias repair. Readers will come away with the current clinical diagnosis and management strategies that they can employ immediately.