This issue of Medical Clinics, guest edited by Dr. Edward Frohlich, is devoted to Hypertension. Articles in this outstanding issue include The Kidney in Hypertension; Heart: Fibrosis, Apoptosis, and Cardiac Failure; Myocardial Ischemia; Oxidative Stress and Hypertensive Diseases; Adherence to Antihypertensive Therapy; Aging and Hypertension; Target Organs and Microbiological Considerations in Hypertensive Diseases; Obesity and Sodium Considerations; Diabetes, Hypertension and Cardiorenal Syndrome; Renal Arterial Disease; Cardiac Transplantation and Hypertensive Diseases; Cardiac Failure: Old and New Challenges; Diastolic Dysfunction and Hypertension; Stiffening of Large Arteries; Genetics and Mechanisms; New Guidelines for Hypertensive Diseases; and Local Renin Angiotensin Systems.

This issue of Medical Clinics of North America, guest edited by Drs. Douglas Paauw and Kim O'Connor, is devoted to Pharmacologic Therapy. Articles in this issue include: Pharmacologic Therapies for Autoimmune and Rheumatologic Conditions; Pharmacologic Therapies for Ophthalmologic Conditions; Pharmacologic Therapies for Neurologic Conditions; Pharmacologic Therapies for Cardiac Conditions; Pharmacologic Therapies in Men’s Health; Pharmacologic Therapies in Anticoagulation; Pharmacologic Therapies in Women’s Health: Menopause Treatment and Contraception; Pharmacologic Therapies in GI disease; Pharmacologic Therapies in Pulmonology and Allergy; Pharmacologic Therapies for Substance Abuse; Pharmacologic Therapies in Infectious Disease; Pharmacologic Therapies for HIV; Pharmacologic Therapies in Type 2 DM; Pharmacologic Therapies in Musculoskeletal Conditions; and Osteoporosis Treatment.

In this issue of Medical Clinics of North America, guest editors Drs. Anand V. Kulkarni and K. Rajender Reddy bring their considerable expertise to the topic of Hepatology: An Update. Top experts in the field cover key topics such as NAFLD; hepatic manifestations of a systemic illness; cirrhosis and portal hypertension; hepatic encephalopathy; ICU care of the patient with cirrhosis; hepatocellular carcinoma; liver transplantation for the non-hepatologist; and more. - Contains 15 relevant, practice-oriented topics including the global burden of chronic liver disease; the rising epidemic of alcoholic hepatitis; inpatient hepatology consultation; frailty and sarcopenia; and more. - Provides in-depth clinical reviews on hepatology, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Medical Clinics of North America, guest editor Dr. Douglas Paauw brings his considerable expertise to the topic of Newer Outpatient Therapies and Treatments. Top experts provide insights into recent pharmacologic treatments, review new uses for old drugs, discuss new technologies used in the outpatient setting, and address complementary/alternative options with strong evidence. - Contains 12 relevant, practice-oriented topics including therapy for hyperlipidemia; newer diabetes therapies and technologies; update on antiviral therapies; update in treatments for men's health; newer therapies for psychiatric disease; and more. - Provides in-depth clinical reviews on newer outpatient therapies and treatments, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Medical Clinics of North America, guest editor Dr. Douglas S. Jacoby brings his considerable expertise to the topic of Update in Preventive Cardiology. Top experts in the field cover key topics such as how to manage patients with elevated triglycerides, and when to refer; biomarkers and advanced lipid testing; cardiovascular genetics; noninvasive imaging for the asymptomatic patient; selecting the best oral contraceptives and hormone replacement therapy for women; racial disparities in preventive cardiology; and more. - Contains 15 relevant, practice-oriented topics including the heart healthy diet; the most evidence-based exercise strategies for men and women; pre-diabetes, obesity, and pharmacologic interventions to lower cardiovascular risk; who should be evaluated for secondary hypertension; what is the optimal LDL; and more. - Provides in-depth clinical reviews on preventive cardiology, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue of Medical Clinics of North America, edited by Dr. Irl Hirsch, is devoted to Diabetes Management. Articles in this issue include: Diabetes Classification Update; Internet Diabetes Management: An Effective, Efficient, and Cost Effective Approach; Monitoring Glycemia in Diabetes; Glycemic Targets: What is the Evidence?; Lifestyle Modification in Diabetes; Metformin, Sufonlyureas, Acarbose, Thiazolidnediones, Bromocriptine, and Colesevalam; Incretins; SGLT-2 inhibitors; Insulin therapy in Type 1 Diabetes; Insulin Therapy in Type 2 Diabetes; Non-Glycemic Targets for Patients with Diabetes; Screening and Treatment for the Primary Care Provider of Common Diabetes Complications; and Polycystic Ovarian Syndrome.

In this issue of Medical Clinics of North America, guest editors Dr. Jeffrey Turner and Ursula Brewster bring their considerable expertise to the topic of An Update in Nephrology. Top experts in the field provide timely updates in CKD, kidney disease, kidney health, renal replacement therapy, and treatments. - Contains 12 practice-oriented topics including diagnosis of CKD and assessing eGFR; diabetic nephropathy; pregnancy in CKD: AKI in pregnant women and management of CKD in the pregnant patient; onco-nephrology; and more. - Provides in-depth clinical reviews on nephrology, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue of Medical Clinics of North America, Guest Edited by Deborah Wolbrette, MD is devoted to Cardiovascular Disease. Dr. Wolbrette has assembled a group of expert authors to review the following topics: Syncope due to Autonomic Dysfunction: Diagnosis and Management; 2013 Lipid Guidelines; 2014 Guideline for the Management of High Blood Pressure (JNC8); How to Follow Patients with Aortic and Mitral Valve Disease; The New Anticoagulants; Management of Atrial Fibrillation; Indications for Pacemakers, Implantable Defibrillators and Resynchronization Therapy; Current Status of Transcatheter Aortic Valve Replacement (TAVR); Chest Pain Evaluation: When to Order Troponin and Stress Tests/Cost Analysis; Indications for Cardiac MRI; Current Management of Heart Failure: When to Refer to Heart Failure Specialist and When is Hospice the Best Option; and Emerging Role of Digital Technology/Remote Monitoring in the Care of Cardiac Patients.

Drs. Tewelde and Reynolds have put together an excellent issue on Cardiovascuar Emergencies. Articles include:Pregnancy Related Coronary Artery Disease, Decompensated Cyanotic Heart Disease, Blunt Cardiac Injury, Blunt Cardiac Injury, STEMI Chameleons, Hypertensive Emergency, Troubleshooting the Pacer/ICD, Cardiogenic Shock, Cardiac Arrest, and more!

In this issue of Medical Clinics of North America, guest editors Drs. Heather Toth, Robert Kliegman, and Brett Bordini brings their considerable expertise to the topic of Adolescent Undiagnosed and Rare Diseases. Top experts address diagnostic dilemmas, disease mimics, unusual manifestations of common diseases, and rare disorders presenting as more common diseases in adolescents. - Contains 15 relevant, practice-oriented topics including syndromes with severe acne; common variable immunodeficiency (CVID); overlapping pain syndrome; late onset congenital hypoventilation syndrome (LOCH); adolescent onset of muscle weakness; and more. - Provides in-depth clinical reviews on adolescent undiagnosed and rare diseases, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.