Coronaviruses were recognized as a group of enveloped, RNA viruses in 1968 and accepted by the International Committee on the Taxonomy of Viruses as a separate family, the Coronaviridae, in 1975. By 1978, it had become evident that the coronavirus genomic RNA was infectious (i. e. , positive strand), and by 1983, at least the framework of the coronavirus replication strategy had been per ceived. Subsequently, with the application of recombinant DNA techniques, there have been remarkable advances in our understanding of the molecular biology of coronaviruses, and a mass of structural data concerning coronavirus genomes, mRNAs, and pro teins now exists. More recently, attention has been focused on the role of essential and accessory gene products in the coronavirus replication cyde and a molecular analysis of the structure-function relation ships of coronavirus proteins. Nevertheless, there are still large gaps in our knowledge, for instance, in areas such as the genesis of coronavirus subgenomic mRNAs or the function of the coronavirus RNA-dependent RNA polymerase. The diseases caused by coronaviruses have been known for much longer than the agents themselves. Possibly the first coronavirus-related disease to be recorded was feline infectious peritonitis, as early as 1912. The diseases associ ated with infectious bronchitis virus, transmissible gastroenteritis virus, and murine hepatitis virus were all well known before 1950.

Since the identification of the first cases of the coronavirus in December 2019, there has been a significant amount of confusion regarding the origin and spread of the so-called 'coronavirus', SARS-CoV-2, and the cause of the disease COVID-19. Conflicting messages from the media and officials across different countries and organizations, the abundance of disparate sources of information, unfounded conspiracy theories on the origins of the virus, unproven therapies, and inconsistent public health measures, have all served to increase anxiety in the population. Where did the virus come from? How is it transmitted? How does it cause disease? Is it like flu? What is a pandemic? In this concise and accessible introduction, a leading expert provides answers to these commonly asked questions. This revised and updated edition now also covers how the virus mutates, how important these mutations are, how vaccines work, and what we can expect in the near and long-term future.

This book covers over 24 country studies on various dimensions associated with the geographical spread of COVID-19. The chapters in the book, from geographically diversified countries, assert the need to undertake intensive regional research in order to understand the global pattern of Coronavirus focusing on infection migration, and indigenous origin that has caused tremendous global economic, social and health disaster. The book contends that understanding of peoples’ behaviour is crucial towards safety measures against infection, as COVID-19 impacted to a greater extent social wellbeing of population because of lockdowns in all corners of the world. Some of the countries featured are USA, France, Italy, Hong Kong, South Korea, Canada, Australia, Pacific Islands, Russia, Taiwan, Thailand, Malaysia, Indonesia, India, South Africa, Nigeria, Mexico, Peru and Brazil.

Paperback. ISBN 978-1-912530-35-9. In this timely book, internationally renowned experts review literally every aspect of cutting edge coronavirus research providing the first coherent picture of the molecular and cellular biology since the outbreak of SARS in 2003. Essential reading for all coronavirologists as well as scientists working on other viruses of the respiratory and/or gastrointestinal tract.

The coronaviruses are ssRNA viruses that infect a wide range of mammalian and avian species; they are important causes of respiratory and enteric disease, encephalomyelitis, hepatitis, serositis and vasculitis domestic animals. In humans coronaviruses are one of several groups of viruses that cause the common cold. The genus Coronavirus together with the genus Torovirus from the family Coronaviridae; members of these two genera are similar morphologically. The Coronaviridae, Arteriviridae, and Roniviridae are within the order Nidovirales. Seven coronaviruses are known to infect humans, three of them are serious, namely, SARS (severe acute respiratory syndrome, China, 2002), MERS (Middle East respiratory syndrome, Saudi Arabia, 2012), and SARS-CoV-2 (2019-2020). SARS is caused by a coronavirus (SARS-CoV) which exists in bats and palm civets in Southern China. Its family is Coronaviridae, and its genus is Coronavirus. The most important groups who are at risk are family members in close contact with cases, health-care workers in close contact with cases, elderly and immune compromised individuals appear at increased risk. MERS-CoV is a zoonotic virus which can lead to secondary human infections. It is the sixth coronavirus that influences human. MERS-CoV is most likely derived from an ancestral reservoir bats. MERS outbreak was found in the Republic of Korea since 2015. Coronavirus entry is initiated by the binding of the spike protein (S) to cell receptors, specifically, dipeptidyl peptidase 4 (DDP4) and angiotensin converting enzyme 2 (ACE2) for MERS-CoV and SARS-CoV, respectively. The genome sequence analysis has shown that SARS-CoV-2 belongs to betacoronavirus genus, which includes Bat SARS-like coronavirus, SARS-CoV and MERS-CoV. On the basis of nucleic acid sequence similarity, the newly identified 2019-nCoV is a betacoronavirus. The RBD portion of the SARS-CoV-2 pike proteins has evolved to effectively target a molecular feature on the outside of human cells called ACE2, a receptor involved in regulating blood pressure. The SARS-CoV-2 spike protein was found so effective at binding the human cells. In SARS-CoV-2, M protein is responsible for the transmembrane transport of nutrient, the bud release and the formation of envelope, S protein, attaching to hose receptor ACE2, including two subunits S1 and S2. These diseases can be considered important models for emerging infectious diseases as it emerged from natural animal reservoirs. Early recognition, prompt isolation and appropriate supportive therapy are the main parameters in combating with these deadly infections.

This timely collection brings together original explorations of the COVID-19 pandemic and its wide-ranging, global effects on human rights. The contributors argue that a human rights perspective is necessary to understand the pervasive consequences of the crisis, while focusing attention on those being left behind and providing a necessary framework for the effort to 'build back better'. Expert contributors to this volume address interconnections between the COVID-19 crisis and human rights to equality and non-discrimination, including historical responses to pandemics, populism and authoritarianism, and the rights to health, information, water and the environment. Highlighting the dangerous potential for derogations from human rights, authors further scrutinize the human rights compliance of new legislation and policies in relation to issues such as privacy, protection of persons with disabilities, freedom of expression, and access to medicines. Acknowledging the pandemic as a defining moment for human rights, the volume proposes a post-crisis human rights agenda to engage civil society and government at all levels in concrete measures to roll back increasing inequality. With rich examples, new thinking, and provocative analyses of human rights, COVID-19, pandemics, crises, and inequality, this book will be of key interest to scholars, students, and practitioners in all areas of human rights, global governance, and public health, as well as others who are ready to embark on an exploration of these complex challenges. The Open Access version of this book, available at http: //www.taylorfrancis.com, has been made available under a Creative Commons Attribution (CC-BY) 4.0 license.

Pathogenic Coronaviruses of Humans and Animals: SARS, MERS, COVID-19, and Animal Coronaviruses with Zoonotic Potential provides relevant information about common human coronaviruses that may mutate to increase their virulence. The addition of animal coronaviruses allows awareness of not only the potential of zoonotic transmission of coronaviruses from wild animals such as bats and rodents, but also from domestic agricultural and companion animals. The book opens with an introductory chapter on viruses, the immune system, coronaviruses, and their classifications, prevention and protection. Sections also cover history, disease, causative virus, immune response, diagnosis, treatment, prevention and surveillance. The book's remaining chapters discuss coronaviruses with possible zoonotic transmission of domestic, semi-domestic animals and companion animals. It concludes with future perspectives of coronavirus mutations, modeling, protective measures and a discussion around pandemics and infectious diseases from around the globe. - Covers SARS-CoV, MERS-CoV and SARS-CoV-2 as well as coronaviruses with possible zoonotic transmission of domestic, semi-domestic animals and companion animals - Complements previous studies by bringing together information that compares human and animal coronaviruses - Includes a glossary and coronavirus disease overviews of humans and animals

Scientific literature on SARS-COV-2 viruses and its variants (especially variants of concern such as the ‘Delta variant’) and important cellular targets is crucial to help researchers, virologists and clinicians around the globe to develop a new generation of safer and more effective vaccines, and other treatments to address COVID-19 disease. The accompanying damage to the many organs and tissues of SARS-Co-2-infected people also needs to be understood and researchers are using data to devise meaningful protocols for treating these symptoms. This second volume of Coronaviruses brings together more useful information about the prevention/vaccination, and chemotherapies for the potential treatment of coronavirus infections. The volume includes eight chapters: (1) Broad spectrum antivirals to combat COVID-19 The reality and challenges, (2) COVID-19: Preventive and protective control management strategies, (3) Plant-derived extracts and bioactive compounds against coronavirus progression: preventive effects, mechanistic aspects, and structures, (4) Gastroenteritis: symptoms and epidemiology of SARS-CoV-2, (5) The chronicles of coronavirus: A Chinese king who conquered the entire world, (6) Traditional medicine as a natural remedy in ARDS & COVID-19, (7) Molecular pathogenesis of human coronaviruses of the 21st century, (8) COVID-19, mental health and neuropathophysiology of pain related to temporomandibular disorder. The volume serves as a novel compilation of key data on SARS-CoV-2 and COVID-19 and represents a resource of the utmost value for all scholars studying SARS-CoV infections. It should also be of great interest to clinicians who may be facing an overwhelming number of individuals affected with COVID-19, with over 267 million global cases documented as of the first week of December 2021).

Human coronaviruses caused the SARS epidemic that infected more than 8000 people, killing about ten percent of them in 32 countries. This book provides essential information on these viruses and the development of vaccines to control coronavirus infections.

-SARS has received much attention and coverage by the media and has a high impact on the public making this a hot research topic for scientists. -