Human and Animal Filariases The rational approach to controlling human and animal diseases caused by nematodes Filariae are a family of parasitic worms which infect animals and humans, causing severe diseases such as elephantiasis (lymphatic filariasis) and river blindness (onchocerciasis) in humans, as well as heartworm disease (dirofilariasis) in dogs and cats. While the human diseases are rarely fatal, the blindness and disfiguration resulting from these infections constitute a severe burden for the affected individuals and to the healthcare systems in many tropical countries. In 2017, the World Health Organization classified several filariases as neglected tropical diseases and announced a new program seeking to eradicate these infections, which has in turn sparked a new push to develop antifilarial drugs. Considering the current and future import of this topic, Human and Animal Filariases takes a comprehensive look at infections by filarial parasites in humans and in animals. It begins by reviewing the current state of diagnosis and chemotherapy, before addressing the increasing resistance to available antifilarial drugs. This is followed by strategies and approaches for the discovery of novel drugs and finally by looking at alternative and supplementary approaches to combat the parasites, including vector control and vaccination. Human and Animal Filariases readers will find: A comprehensive approach that integrates current chemotherapy with recent advances in antifilarial drug discovery Practical information on assay development, target validation, and required drug product profiles Insights from global experts from leading academic institutions as well as from pharma and healthcare companies Human and Animal Filariases is a unique reference for parasitologists, veterinarians, as well as professionals in the pharmaceutical industry and in public health agencies.

Wolbachia are Gram-negative bacteria that form intracellular inherited infections in many invertebrates. They are extremely common, with 20-75% of all insects being infected. Transmitted to humans through mosquitoes and black flies, the majority of the disease-causing nematodes are hosts to the Wolbachia bacteria. Featuring the findings of internationally recognized experts in infectious disease research and insect biology, thie publication highlights their perpectives of Wolbachia's genome, evolution, symbiosis, biology, pathogenicity as well as its potential as a drug taraget.

The increase of immigrant population in developed countries (mainly in Europe and North America) together with an important increase of international travel worldwide are the two most important causes that have contributed to the introduction and diagnosis of imported/tropical infectious diseases in these countries. These factors have had an important impact in developed countries in both social and economic aspects. Imported Infectious Diseases focuses not only on describing the infections, but also in evaluating the current epidemiology, the economic and social impact and the possibility to apply immunization measures and vaccines. The main purpose of this book is to give an overview of the current most important and frequent imported infectious diseases in developed countries. The first chapter informs about the medical services that are being offered to the immigrants in the main developed countries depending on the legal situation. Following chapters describe the main surveillance systems for these kinds of diseases, mainly in Europe and North America. Finally, remaining chapters contain sections on epidemiology, pathogenesis, clinical features, diagnosis, treatment and prevention.

Zoonoses are a persistent threat to the global human health Today, more than 200 diseases occurring in humans and animals are known to be mutually transmitted. Classical infectious diseases, such as rabies, plague, and yellow fever, have not been eradicated despite major efforts. New zoonotic diseases are on the increase due global conditions such as overpopulation, wars, and food scarcity, which facilitate human contact with rodents, stray animals, and their parasites. In addition, humans are unwittingly becoming accidental hosts and new links in an infectious chain by engaging in activities such as survival training, which involves camping in open areas and consumption of raw or insufficiently cooked food. Zoonotic infections cause a variety of symptoms that often do not provide clear evidence of a known disease. Zoonoses, Fourth Edition, describes most occurring worldwide zoonosis and facilitates the identification, diagnosis and treatment of zoonotic infections. Written by a team of doctors, medical microbiologists and veterinarians, this completely, revised edition covers all aspects of the epidemiology and prevention of zoonotic diseases through clear descriptions of various illnesses. Specifically, this fourth edition covers zoonosis caused by viruses, bacteria, fungi and parasites infections caused by animal bites infections and intoxications by animal foods Iatrogenic transmission of zoonotic pathogens Zoonoses is an indispensable reference for clinicians and laboratorians.

H1N1 ("swine flu"), SARS, mad cow disease, and HIV/AIDS are a few examples of zoonotic diseases-diseases transmitted between humans and animals. Zoonotic diseases are a growing concern given multiple factors: their often novel and unpredictable nature, their ability to emerge anywhere and spread rapidly around the globe, and their major economic toll on several disparate industries. Infectious disease surveillance systems are used to detect this threat to human and animal health. By systematically collecting data on the occurrence of infectious diseases in humans and animals, investigators can track the spread of disease and provide an early warning to human and animal health officials, nationally and internationally, for follow-up and response. Unfortunately, and for many reasons, current disease surveillance has been ineffective or untimely in alerting officials to emerging zoonotic diseases. Sustaining Global Surveillance and Response to Emerging Zoonotic Diseases assesses some of the disease surveillance systems around the world, and recommends ways to improve early detection and response. The book presents solutions for improved coordination between human and animal health sectors, and among governments and international organizations. Parties seeking to improve the detection and response to zoonotic diseases-including U.S. government and international health policy makers, researchers, epidemiologists, human health clinicians, and veterinarians-can use this book to help curtail the threat zoonotic diseases pose to economies, societies, and health.

This book offers a valuable resource, reviewing the current state of knowledge concerning the pathology and epidemiology of infectious diseases in both captive and wild monkeys. The One Health concept forms the framework of all chapters. The multidisciplinary team of authors addresses neglected diseases caused by the three major pathogen groups - bacteria, viruses, and parasites. Moreover, the volume discusses key virulence factors such as the evolution of antibiotic resistance, and the ecological drivers of and human influence on pathogen transmission. Demonstrating how researchers working on monkeys diseases are increasingly thinking outside the box, this volume is an essential reference guide to the field of One Health and will serve as an asset for stakeholders in conservation, healthcare and research organizations that face the challenge of moving beyond classical human oriented approaches to health.

Prevent, evaluate, and manage diseases that can be acquired in tropical environments and foreign countries with The Travel and Tropical Medicine Manual. This pragmatic resource equips medical providers with the knowledge they need to offer effective aid, covering key topics in pre- and post-travel medicine, caring for immigrants and refugees, and working in low-resource settings. It's also the perfect source for travelers seeking quick, easy access to the latest travel medicine information. - Dynamic images illustrate key concepts for an enhanced visual understanding. - Evidence-based treatment recommendations enable you to manage diseases confidently. - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. - Evidence-based appendix, available at Expert Consult, helps to validate treatments. - Highlights new evidence and content surrounding mental health and traveling. - Covers emerging hot topics such as Ebola virus disease, viral hemorrhagic fevers, the role of point-of-care testing in travel medicine, and antibiotic-resistant bacteria in returning travelers and students traveling abroad. - Includes an enhanced drug appendix in the back of the book.

Canine Parasites and Parasitic Diseases offers a concise summary, including the distribution, epidemiology, lifecycle, morphology, clinical manifestations, diagnosis, prophylaxis and therapeutic measures on the most important parasites affecting dogs. The book includes their classification, structure, lifecycles, occurrence, and the diagnosis and treatment of infestations. Chapters are presented in a consistent and logical format with extensive use of tables, photographs and line drawings that help veterinarians and students quickly find answers to questions. The book informs on 100 different species of parasite related to the canine world and is is aimed not only at veterinary practitioners but also in dog enthusiasts, pharmacies and laboratories. - Fully illustrated with high-quality figures and illustrations - Provides insights on the risk factors and prevention of parasite infections in dogs and gives guidelines for anthelmintic treatment - Serves professionals, students, parasitologists and veterinary scientists - Present an easy-to-use handbook on the identification of canine parasites and the diseases associated with parasitic infection

This book highlights the most significant diseases for humans and their dogs, cats and horses. The examples discussed, which include allergies, osteoporosis, cancer and many more, illustrate that humans and their companion animals may in fact develop similar diseases. The reader - whether expert or interested lay - can thus directly compare between human and animal patients. The animal patient thereby represents a natural disease model, which besides the experimental models, is urgently needed to improve the therapeutic options for both humans and animals.

In an increasingly global community, the rapid adaptation of microorganisms has facilitated the return of old communicable diseases and the emergence of new ones. Tropical Dermatology, 2nd Edition, provides a practical, highly illustrated approach to the diagnosis and treatment of a wide range of tropical skin diseases. In a concise and user-friendly format, it offers authoritative coverage of epidemiology, diagnosis, differential diagnosis, pathology, laboratory tests, management, and prevention for both common and rare conditions. - Examines the full range of tropical skin diseases in an easy-to-reference format, with consistently organized, templated chapters. - Structures clinical guidance by disease rather than by microbe or "bug." - Covers the key issues for travelers, important considerations for people working in the tropics, and non-infectious conditions. - Provides authoritative guidance for dermatologists, infectious disease specialists, and travel medicine physicians. - Includes new chapters on Tungiasis, Ebola and Zika virus. - Features updates on emerging diseases and new therapies throughout. - Includes brand-new, "hard-to-find" clinical images, for a total of more than 650 full-color illustrations throughout. - Integrates the knowledge and experience of new international contributors, including recognized experts in dermatology from the United States, Europe, South America, Africa, and Asia. - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices.