This book covers topics that range from fundamental studies of DNA replication, chromosomal and nuclear function through growth factor control of endocrine tumor initiation and progression. The basic and translational insights gained from Hormonal Control of Cell Cycle will be of interest to those studying the biology of endocrine tumors as well as those deriving novel therapeutic approaches for these benign and malignant disorders.

In recent years, the study of the plant cell cycle has become of major interest, not only to scientists working on cell division sensu strictu , but also to scientists dealing with plant hormones, development and environmental effects on growth. The book The Plant Cell Cycle is a very timely contribution to this exploding field. Outstanding contributors reviewed, not only knowledge on the most important classes of cell cycle regulators, but also summarized the various processes in which cell cycle control plays a pivotal role. The central role of the cell cycle makes this book an absolute must for plant molecular biologists.

Biology for AP® courses covers the scope and sequence requirements of a typical two-semester Advanced Placement® biology course. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology for AP® Courses was designed to meet and exceed the requirements of the College Board’s AP® Biology framework while allowing significant flexibility for instructors. Each section of the book includes an introduction based on the AP® curriculum and includes rich features that engage students in scientific practice and AP® test preparation; it also highlights careers and research opportunities in biological sciences.

The cell cycle in plants consists of an ordered set of events, including DNA replication and mitosis, that culminates in cell division. As cell division is a fundamental part of a plant's existence and the basis for tissue repair, development and growth, a full understanding of all aspects of this process is of pivotal importance. Cell Cycle Control and Plant Development commences with an introductory chapter and is broadly divided into two parts. Part 1 details the basic cell machinery, with chapters covering cyclin-dependent kinases (CDKs), cyclins, CDK inhibitors, proteolysis, CDK phosphorylation, and E2F/DP transcription factors. Part 2, which describes the cell cycle and plant development, covers cell cycle activation, cell cycle control during leaf development, endoreduplication, the cell cycle and trichome, fruit and endosperm development, the hormonal control of cell division and environmental stress, and cell cycle exit. The editor of this important book, Professor Dirk Inzé, well known and respected internationally, has brought together an impressive team of contributing authors, providing an excellent new volume in Blackwell Publishing's Annual Plant Reviews Series. The book is an essential purchase for research teams working in the areas of plant sciences and molecular, cell and developmental biology. All libraries in universities and research establishments where biological sciences are studied and taught should have copies of this essential and timely volume.

This monograph on plant cell division provides a detailed overview of the molecular events which commit cells to mitosis or which affect, or effect mitosis.

Although the cause of breast cancer has not been identified yet, there is enough clinical and experimental evidence that full term pregnancy reduces the lifetime risk of developing breast cancer, a protective effect that can be mimicked by treatment of virgin animals with the placental hormone chorionic gonadotropin (hCG). In vivo this hormone inhibits both the initiation and progression of rat mammary carcinomas, and in vitro the proliferation of human breast epithelial cells (HBEC). Work performed under this grant application has led the PL to determine that treatment of immortalized, chemically transformed and malignant HBEC with hCG activates programmed cell death genes even before an arrest of cell growth has becomes evident. It also acts as an inhibitor of cell proliferation, utilizing different pathways for either activating programmed cell death genes or inhibiting specific cell cycle dependent kinases, depending upon the degree of expression of neoplastic phenotypes. The relevance of these findings lies in the potential use of hCG as a chemopreventive and chemotherapeutic agent in breast cancer, utilizing the detection of activation of programmed cell death genes as an early end point in the action of this hormone on the target tissues.