17-year-old Kate has lived her whole life in abject poverty, with an alcoholic father and drug-addicted mother, who severely abuses Kate. At school, her second-hand clothing marks her as a target. Her refusal to stand up for herself makes her the recipient of her classmates taunts and bullying. That is, until Henry returns. Henry Jamison moved away six years earlier, just as he and Kate had begun an to develop feelings for one another. He returns to find the bright, funny, outgoing girl he had known now timidly hiding in corners, barely speaking to anyone around her, suspicious of even him. Kate can't figure out what game Henry is playing with her - for surely it is a game. What else would the gorgeous, popular boy from her past want with her? Kate finally decides to trust Henry's intentions, opening her heart to him. Just when it seems he might be genuine in his friendship, tragedy strikes, threatening everything Kate has worked so hard to gain. Can Henry help her to overcome this new devastation, or will it tear them apart forever?

Valentines come in all sorts of shapes and sizes. Some are homemade and some are store-bought. Some are funny and some are not. Sam wants to give just the right valentine to the most popular girl in the class, Tiffany. But what kind is the right kind? Mary Ann helps Sam figure out how to make all sorts of valentines. But will Tiffany even notice Sam if he gives her a special valentine? Laura Malone Elliott and Lynn Munsinger’s charming story shows how the best friends are often the ones you may not know you have—until Valentine’s Day!—and even a simple string of hearts can show a friend how special he is.

Winner of the Bram Stoker Award for Best Novel In her quickly gentrifying rural lake town Jade sees recent events only her encyclopedic knowledge of horror films could have prepared her for in this latest chilling novel that “will give you nightmares. The good kind, of course” (BuzzFeed) from the Jordan Peele of horror literature, Stephen Graham Jones. “Some girls just don’t know how to die…” Shirley Jackson meets Friday the 13th in My Heart Is a Chainsaw, written by the New York Times bestselling author of The Only Good Indians Stephen Graham Jones, called “a literary master” by National Book Award winner Tananarive Due and “one of our most talented living writers” by Tommy Orange. Alma Katsu calls My Heart Is a Chainsaw “a homage to slasher films that also manages to defy and transcend genre.” On the surface is a story of murder in small-town America. But beneath is its beating heart: a biting critique of American colonialism, Indigenous displacement, and gentrification, and a heartbreaking portrait of a broken young girl who uses horror movies to cope with the horror of her own life. Jade Daniels is an angry, half-Indian outcast with an abusive father, an absent mother, and an entire town that wants nothing to do with her. She lives in her own world, a world in which protection comes from an unusual source: horror movies…especially the ones where a masked killer seeks revenge on a world that wronged them. And Jade narrates the quirky history of Proofrock as if it is one of those movies. But when blood actually starts to spill into the waters of Indian Lake, she pulls us into her dizzying, encyclopedic mind of blood and masked murderers, and predicts exactly how the plot will unfold. Yet, even as Jade drags us into her dark fever dream, a surprising and intimate portrait emerges…a portrait of the scared and traumatized little girl beneath the Jason Voorhees mask: angry, yes, but also a girl who easily cries, fiercely loves, and desperately wants a home. A girl whose feelings are too big for her body. My Heart Is a Chainsaw is her story, her homage to horror and revenge and triumph.

Set among the Malibu mansions and Hollywood rock clubs of California's southland, Never Break the Chain finds Tim Green's grief over the loss of his father spinning into an obsessive quest to track down the wayward mother who deserted him almost three decades before. It's a journey that, like Believe in Me before it, sends Green venturing deep into the heart of the rock and roll jungle. Opening a few months after the end of Believe in Me, Never Break the Chain lands Green in the oceanfront Malibu compound of British guitarist Blake Saunders, who's just hired him to pen an authorized biography of his floundering, formerly-huge arena rock band. Even as the highly combustible Saunders' son Mal-recently installed as the band's new lead singer-and daughter Jane offer him distorted reflections of himself, Green's efforts to retrace his mother's steps through LA's rock and roll underworld propel him toward a cathartic confrontation. The revelations to come challenge every answer he once thought he possessed to the most fundamental question of all: who is Tim Green? Equal parts family drama, literate thriller, and peek behind the curtain of an aging rock band, Never Break the Chain is ultimately a story about families-the ones we're born into, and the ones we create. Praise for Never Break the Chain: "Rock writer Jason Warburg ties up some loose ends with his latest Tim Green novel, Never Break the Chain. His charming protagonist is still threading the road to self-knowledge by poetically and amusingly examining the lives of others in this tale of excess and success. Best of all, a turn in the story resolves the mystery of who Tim Green really is. It's the magic of music that takes us there, along with Warburg's very entertaining style." -- Viola Weinberg, Poet Laureate emerita of Sacramento & former KZAP FM News Director "A beautiful book... Never Break the Chain is a novel about family life and the ties that bind people together. It is not easy to write about music and the life of musicians in a convincing way, but Jason Warburg never misses a beat. Warburg understands how music can play a major part in the staging posts of people's lives." -- Greg Spawton, co-founder & songwriter, Big Big Train

The Stressed Heart is truly unique in concept and will provide an eXCItmg adventure to the reader no matter what his or her field of expertise and interest. The title, although quite appropriate, does not adequately indicate the range of topics considered or the rational interrelationships among them. Indeed, perhaps the most important point to be learned from the book is that a serious consideration of the response of the heart to mechanical overload, ischemia, or excessive humoral stimuli must include evaluation of each of the topics in the table of contents. The heart responds to stress through alterations in both structure and function. How these changes are brought about is the subject of the initial chapters. These consider first the normal regulation of gene expression in the heart, the rapid response to mechanical overload that leads to both quantitative and qualitative changes in the contractile proteins, and our current understand ing of the signals that might be elicited by stress and alter gene expression. One chapter emphasizes the fact that, regardless of the nature of the stress, the common denominator is a discrepancy between energy requirements and expenditure. The central role of cellular acidosis in initiating the sequence of responses to stress and the possible roles of peptide regulators of transcription and protein regulators of translation are considered in detail.

Cardiovascular dynamics is a field in which modelling and systems analysis have formed an extremely important discipline. For example, understanding of even such a fundamental function of the circulation as the relationship between central venous pressure apd cardiac output has required evolution of a pertinent model based on years of exhaustive ex perimental investigations by Starling, Starr, and Guyton. Hemodynamic analyses of pulsatile pressures and flows in the arteries and veins have been a continuing challenge taken up by champions of fluid dynamics such as Frank, Wetterer, Taylor, and Wormersley, just to mention a few names, and some kind of model was always proposed as a conceptual framework. An even greater challenge to cardiovascular dynamicists was how to analyze the intermittent coupling of the ventricle and the arterial or venous vasculature through the valve. The availability of numerical solutions by computer and the recently evolved ventricular model with a time-varying elastance and a pressure-dependent internal resistance opened the way to analysis of this coupling. The ever increasing speed of computers has also facilitated trips between the fre quency and the time domain, even on-line for some experimental studies. This book contains many analyses dedicated to the interactions between the heart and the vasculature, providing the reader with findings at the cutting edge of current research in this field.

Whenever the heart is challenged with an increased work load for a prolonged period, it responds by increasing its muscle mass--a phenomenon known as cardiac hypertrophy. Although cardiac hypertrophy is commonly seen under physiological conditions such as development and exercise, a wide variety of pathological situa tions such as hypertension (pressure overload), valvular defects (volume overload), myocardial infarction (muscle loss), and cardiomyopathy (muscle disease) are also known to result in cardiac hypertrophy. Various hormones such as catecholamines, thyroid hormones, angiotensin II, endothelin, and growth factors have also been shown to induce cardiac hypertrophy. Although the exact mechanisms underlying or pathological forrns of cardiac hypertrophy are poorly under the physiological stood, an increase in the intraventricular pressure is believed to represent the major stimulus for the development of cardiac hypertrophy. In this regard, stretching of the cardiac muscle has been shown to induce the hypertrophic response, but the role of metabolic influences in this process cannot be ruled out. Furthermore, different hormones and other interventions in the absence of stretch have been observed to stimulate protein synthesis in both isolated cardiomyocyte and vascular myocyte preparations. Nonetheless, it is becoming dear that receptor as well as phospholipid linked signal transduction pathways are activated in some specific manner depend ing upon the initial hypertrophic stimulus, and these then result in an increase in the size and mass of cardiomyocytes.

The first edition of this book was quite successful. As in the first edition, the book is divided into two major sections: cardiac muscle and coronary circula Several complimentary book reviews appeared soon tion. The book is multidisciplinary and includes after the first edition was published, and written and membrane biophysics, electrophysiology, physiol oral words of praise and appreciation were given both ogy, pathophysiology, pharmacology, biochemistry, to the publisher and to me by quite a few individuals. and ultrastructure. Thus, the book attempts ro It is because of such positive comments and reactions that the publisher and I decided to embark on a integrate all relevant aspects of the factors influenc second edition of Physiology and Pathophysiology of the ing the function of the heart as a vital organ under Heart. The second edition was long in preparation, normal and various abnormal conditions. The book taking over a year to complete. All chapter contri also attempts to set the foundation for an under butors were asked to revise, improve, and update standing of the action and mechanism of action of a their articles, and all have done so with enthusiasm number of classes of cardioactive drugs.

Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students.Key Features* The most comprehensive book available on this topic* Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology* Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology* Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology

In recent years, several scientific papers have highlighted the role of the thyroid system in cardioprotection, and several clinical studies – including multicenter studies – have identified the role of thyroid hormones (TH) in the development and progression of cardiovascular disease, making an update of TH and heart relationship both necessary and timely. This second edition of Thyroid and Heart failure provides a careful and updated review of the experimental, clinical and epidemiological results in the field of TH and heart failure, with a particular focus on the translational - bench to bedside - significance of the obtained results. It discusses topics such as the molecular, structural, functional, cellular and histological cardiac changes; the reversibility of these changes with TH replacement therapy; the systemic effects – kidney, hormonal pathways systems, brain, muscle, etc – of altered TH metabolism in HF, as well as the clinical and prognostic implications. The section devoted to the potential therapeutic treatments has been expanded. Thanks to its translational approach to this highly complex subject, the book will be of interest to a broad readership, including cardiologists, endocrinologists and internists.