Handbook For Chemical Process Research And Development
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Author |
: Wenyi Zhao (Chemist) |
Publisher |
: |
Total Pages |
: 0 |
Release |
: 2023 |
ISBN-10 |
: 1003288413 |
ISBN-13 |
: 9781003288411 |
Rating |
: 4/5 (13 Downloads) |
Synopsis Handbook for Chemical Process Research and Development by : Wenyi Zhao (Chemist)
"This fully updated second edition reflects the significant changes in process chemistry since the first edition and includes more common process issues such as safety, cost, robustness, and environmental impact. Some areas have made notable progress such as process safety, stereochemistry, new reagents and reagent surrogates. Forty years ago there were few process research and development activities in the pharmaceutical industry, partly due to the simplicity of drug molecules. With increasing structural complexity especially the introduction of chiral centers into drug molecules and stricter regulations, process R&D has become one of the critical departments for pharmaceutical companies"--
Author |
: Wenyi Zhao |
Publisher |
: CRC Press |
Total Pages |
: 938 |
Release |
: 2023-03-21 |
ISBN-10 |
: 9781000859058 |
ISBN-13 |
: 1000859053 |
Rating |
: 4/5 (58 Downloads) |
Synopsis Handbook for Chemical Process Research and Development, Second Edition by : Wenyi Zhao
This fully updated second edition reflects the significant changes in process chemistry since the first edition and includes more common process issues such as safety, cost, robustness, and environmental impact. Some areas have made notable progress such as process safety, stereochemistry, new reagents and reagent surrogates. Forty years ago there were few process research and development activities in the pharmaceutical industry, partly due to the simplicity of drug molecules. With increasing structural complexity especially the introduction of chiral centers into drug molecules and stricter regulations, process R&D has become one of the critical departments for pharmaceutical companies. Features: This unique volume now in its second edition is designed to provide readers with an unprecedented strategy and approach which will help chemists and graduate students develop chemical processes in an efficient manner. Promotes an industrial mindset concerning safety and commercial viability when developing methods. The author discusses development strategies with case studies and experimental procedures. Focuses on mechanism-guided process development which provides readers with practical strategies and approaches. Addresses more common process issues such as safety, cost, robustness, and environmental impact. This book provides a new direction for scientists, researchers, and students in materials science and polymer chemistry who seek to better understand the chemistry behind conducting polymers and improve their performance for use in advanced energy applications.
Author |
: Wenyi Zhao |
Publisher |
: CRC Press |
Total Pages |
: 864 |
Release |
: 2016-11-03 |
ISBN-10 |
: 9781315350202 |
ISBN-13 |
: 1315350203 |
Rating |
: 4/5 (02 Downloads) |
Synopsis Handbook for Chemical Process Research and Development by : Wenyi Zhao
The Handbook for Chemical Process Research and Development focuses on developing processes for chemical and pharmaceutical industries. Forty years ago there were few process research and development activities in the pharmaceutical industry, partially due to the simplicity of the drug molecules. However, with the increasing structural complexity, especially the introduction of chiral centers into the drug molecules and strict regulations set by the EMA and FDA, process R&D has become one of the critical departments for pharmaceutical companies. This book assists with the key responsibility of process chemists to develop chemical processes for manufacturing pharmaceutical intermediates and final drug substances for clinical studies and commercial production.
Author |
: Neal G. Anderson |
Publisher |
: Academic Press |
Total Pages |
: 489 |
Release |
: 2012-04-09 |
ISBN-10 |
: 9780123865373 |
ISBN-13 |
: 0123865379 |
Rating |
: 4/5 (73 Downloads) |
Synopsis Practical Process Research and Development by : Neal G. Anderson
Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights: . Reflects the current thinking in chemical process R&D for small molecules . Retains similar structure and orientation to the first edition. . Contains approx. 85% new material . Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up) . Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes) . Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes
Author |
: Himanshu J Patel |
Publisher |
: CRC Press |
Total Pages |
: 572 |
Release |
: 2023-10-06 |
ISBN-10 |
: 9781000969672 |
ISBN-13 |
: 1000969673 |
Rating |
: 4/5 (72 Downloads) |
Synopsis Handbook for Chemical Process Industries by : Himanshu J Patel
Chemical processing industry plays a pivotal role in the economy of a country, as chemicals are required in every sphere of our lives. This book covers chemical processing of dyes, pigments, drugs and pharmaceutical products, fermented products, agrochemicals, explosives, polymers, Period II and III chemicals, chemicals, sugar, coatings, starches, soaps and detergents, paper, pulp, glass, and cement. It includes sources of natural materials, collection process, purification, and extraction of different chemicals from natural materials like petroleum, coal and ores from the Earth. It includes manufacturing details of C1 to C4 and aromatic compounds obtained from natural materials. The book covers both traditional and modern sectors of the chemical processing industry. It provides knowledge on the properties of the chemical and manufacturing process (such as raw materials, chemical reactions, quantitative requirement, flow sheet diagram, procedure) and its uses. The book is based on the author's expertise and has been developed with an awareness of the quantitative requirement for manufacturing chemicals. Data has been collected from industry, thus it will be useful to industry personnel, research groups, academicians and institutional organizations.
Author |
: S. B. Chandalia |
Publisher |
: |
Total Pages |
: 310 |
Release |
: 2002 |
ISBN-10 |
: 8187070145 |
ISBN-13 |
: 9788187070146 |
Rating |
: 4/5 (45 Downloads) |
Synopsis Handbook of Chemical Process Development by : S. B. Chandalia
Author |
: Neal G. Anderson |
Publisher |
: Academic Press |
Total Pages |
: 354 |
Release |
: 2000-03 |
ISBN-10 |
: 1483299775 |
ISBN-13 |
: 9781483299778 |
Rating |
: 4/5 (75 Downloads) |
Synopsis Practical Process Research & Development by : Neal G. Anderson
This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. * Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" * Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more * Includes over 100 tips for rapid process development * Presents guidelines for implementing and troubleshooting processes
Author |
: John Blacker |
Publisher |
: Royal Society of Chemistry |
Total Pages |
: 375 |
Release |
: 2011-08-17 |
ISBN-10 |
: 9781849733076 |
ISBN-13 |
: 1849733074 |
Rating |
: 4/5 (76 Downloads) |
Synopsis Pharmaceutical Process Development by : John Blacker
Pharmaceutical process research and development is an exacting, multidisciplinary effort but a somewhat neglected discipline in the chemical curriculum. This book presents an overview of the many facets of process development and how recent advances in synthetic organic chemistry, process technology and chemical engineering have impacted on the manufacture of pharmaceuticals. In 15 concise chapters the book covers such diverse subjects as route selection and economics, the interface with medicinal chemistry, the impact of green chemistry, safety, the crucial role of physical organic measurements in gaining a deeper understanding of chemical behaviour, the role of the analyst, new tools and innovations in reactor design, purification and separation, solid state chemistry and its role in formulation. The book ends with an assessment of future trends and challenges. The book provides a valuable overview of: both early and late stage chemical development, how safe and scaleable synthetic routes are designed, selected and developed, the importance of the chemical engineering, analytical and manufacturing interfaces, the key enabling technologies, including catalysis and biocatalysis, the importance of the green chemical perspective and solid form issues. The book, written and edited by experts in the field, is a contemporary, holistic treatise, with a logical sequence for process development and mini-case histories within the chapters to bring alive different aspects of the process. It is completely pharmaceutical themed, encompassing all essential aspects, from route and reagent selection to manufacture of the active compound. The book is aimed at both graduates and postgraduates interested in a career in the pharmaceutical industry. It informs them about the breadth of the work carried out in chemical research and development departments, and gives them a feel for the challenges involved in the job. The book is also of value to academics who often understand the drug discovery arena, but have far less appreciation of the drug development area, and are thus unable to advise their students about the relative merits of careers in chemical development versus discovery.
Author |
: Duca, Gheorghe |
Publisher |
: IGI Global |
Total Pages |
: 649 |
Release |
: 2019-12-06 |
ISBN-10 |
: 9781799812432 |
ISBN-13 |
: 179981243X |
Rating |
: 4/5 (32 Downloads) |
Synopsis Handbook of Research on Emerging Developments and Environmental Impacts of Ecological Chemistry by : Duca, Gheorghe
Pollution has been a developing problem for quite some time in the modern world, and it is no secret how these chemicals negatively affect the environment. With these contaminants penetrating the earth’s water supply, affecting weather patterns, and threatening human health, it is critical to study the interaction between commercially produced chemicals and the overall ecosystem. Understanding the nature of these pollutants, the extent in which they are harmful to humans, and quantifying the total risks are a necessity in protecting the future of our world. The Handbook of Research on Emerging Developments and Environmental Impacts of Ecological Chemistry is an essential reference source that discusses the process of chemical contributions and their behavior within the environment. Featuring research on topics such as organic pollution, biochemical technology, and food quality assurance, this book is ideally designed for environmental professionals, researchers, scientists, graduate students, academicians, and policymakers seeking coverage on the main concerns, approaches, and solutions of ecological chemistry in the environment.
Author |
: Martin B. B. Hocking |
Publisher |
: Elsevier |
Total Pages |
: 808 |
Release |
: 2013-10-22 |
ISBN-10 |
: 9781483293721 |
ISBN-13 |
: 1483293726 |
Rating |
: 4/5 (21 Downloads) |
Synopsis Handbook of Chemical Technology and Pollution Control by : Martin B. B. Hocking
Handbook of Chemical Technology and Pollution Control integrates industrial chemistry with pollution control and environmental chemistry. This unified approach provides practicing professionals and consultants with a concise yet authoritative handbook covering the Key Features, relative importance, and environmental impact of currently operating chemical processes. It also meets the critical needs of students training for industrial careers.Handbook of Chemical Technology and Pollution Control considers community, municipal, power generation, industrial, and transportation components of environmental impact. The book covers the major inorganic and organic commodity chemicals; aluminum, iron and steel, and copper prodution; pulp and paper; fermentation; petroleum production and refining. It also includes key topics and process details for major peterochemicals and large-scale consumer and engineering polymers. This single, convenient volume describes aspects of recycling at the industrial and post-consumer levels, and emphasizes a quantitative approach as used in the author's well-known lifecycle work with disposable and reusable cups.0-12-350811-8Key Features* Covers historical background and new developments in a single, authoritative handbook* Presents integrated treatment of chemical technology with emission control chemistry* Includes tables throughout that give current and trend data* Considers community, municipal, power generation, industrial, and transportation components of environmental impact* Provides many references to further reading* Contains review questions that offer working experience with the information and concepts