Popular culture often equates testosterone with virility, strength, and the macho male physique. Viewed by some as an "antiaging tonic," testosterone's reputation and increased use by men of all ages in the United States have outpaced the scientific evidence about its potential benefits and risks. In particular there has been growing concern about an increase in the number of middle-aged and older men using testosterone and the lack of scientific data on the effect it may have on aging males. Studies of testosterone replacement therapy in older men have generally been of short duration, involving small numbers of participants and often lacking adequate controls. Testosterone and Aging weighs the options of future research directions, examines the risks and benefits of testosterone replacement therapy, assesses the potential public health impact of such therapy in the United States, and considers ethical issues related to the conduct of clinical trials. Testosterone therapy remains an attractive option to many men even as speculation abounds regarding its potential.

Testosterone takes a historical approach to understanding testosterone. It is a comprehensive description of the functions of testosterone and its role in determining the biological, medical, psychological, behavioral and cultural features of the male sex/gender and the male/female differences.It is a unique reference that explains not only the biological aspects of the function of testosterone, but also the psychophysical aspects. Unlike most other hormones, testosterone not only regulates biological functions of the body, but its functions are also psychological. This wide spectrum of effects influences nearly all biological and behavioral features of a male, makes testosterone particularly exciting.Sex/gender issues are of great interest for a wide readership of experts within various disciplines and specialties including GP, gynecology, pediatrics, urology, andrology, and endocrinology. - Discusses groundbreaking discoveries about the function of endocrine glands and hormones from the 19th century until present - Includes information on the biology of testosterone production and its effects in men and women, including effects of high and low testosterone - Presents male contraception with its successes and failures as well as future directions and strategies in the development of novel effective male contraceptives - Discusses the correct, questionable and misuse of testosterone treatments

*** RECOMMENDED AS ONE OF THE TIMES' BEST SCIENCE BOOKS OF 2021 'With all the talk about testosterone in sex, sports and politics, we need a good explanation of the science and its implications, and this one is outstanding.' STEVEN PINKER, bestselling author of The Blank Slate 'There are whole books written about the idea that behavioural sex differences are a societal construct and how a male hormone we know influences animal behaviour somehow doesn't influence us. Hooven's book is a riposte to that silliness - and also a defence of a hormone that isn't just about aggression.' TOM WHIPPLE, THE TIMES, BEST SCIENCE BOOKS OF 2021 'Fascinating, vital, unputdownable.' JULIE BINDEL 'The definitive book on testosterone . . . A brave and significant book . . . simply fascinating and filled with extraordinary facts.' EVENING STANDARD 'Testosterone does what all superb popular science must do: it entertains as it educates.' THE WALL STREET JOURNAL Through riveting personal stories and the latest research, Harvard evolutionary biologist Carole Hooven shows how testosterone drives the behaviour of the sexes apart and how understanding the science behind this hormone is empowering for all. The biological source of masculinity has inspired fascination, investigation and controversy since antiquity. From the eunuchs in the royal courts of ancient China to the booming market for 'elixirs' of youth in nineteenth-century Europe, humans have been obsessed with identifying and manipulating what we now know as testosterone. And the trend shows no signs of slowing down. Thanks to this history and the methods of modern science, today we have a rich body of research about testosterone's effects in both men and women. The science is clear: testosterone is a major, invisible player in our relationships, sex lives, athletic abilities, childhood play, gender transitions, parenting roles, violent crime, and so much more. But there is still a lot of pushback to the idea that it does, in fact, contribute to sex differences and significantly influence behaviour. Hooven argues that acknowledging testosterone as a potent force in society doesn't reinforce stifling gender norms or patriarchal values. Testosterone and evolution work together to produce a huge variety of human behaviour, and that includes a multitude of ways to be masculine and feminine. Understanding the science sheds light on how we work and relate to one another, how we express anger and love, and how we fight bias and problematic behaviour to build a fairer society.

New developments in testosterone therapy are summarized here by internationally renowned experts. They review both basic and clinical knowledge in fourteen chapters. The book begins with the biochemistry of testosterone, its biosynthesis, metabolism and mechanisms of action in target organs. Three chapters deal with specific aspects of testosterone action, namely its role in spermatogenesis, its psychotropic effects and its effects on bones. Syndromes caused by androgen resistance are described in order to highlight the importance of properly functioning enzymes and receptors in the target organs. Causes and symptoms of male hypogonadism, the major indication for testosterone treatment, are described. Five chapters are devoted to the pharmacology, pharmacokinetics and clinical uses and abuses of testosterone preparations. The new transdermal testosterone application is described in detail. Side effects of testosterone treatment are reviewed. The possible role of androgens in the development of prostatic hypertrophy and carcinoma is discussed extensively since this question is of major concern to the clinician.

A groundbreaking workout and diet plan that replenishes a man's testosterone levels, rebuilds his body, and remakes his life Testosterone is the most crucial hormone in the male body--and every man's T levels begin a slow, steady decline as he ages. The result? Loss of strength and muscle mass. Poor sugar metabolism. Increased body fat, especially around the waist. Loss of T also affects red blood cell production, vitality, bone density, mental acuity, and sex drive. In short: It slowly chops a man down. Testosterone Transformation helps a man produce higher levels of T and reverse the downward spiral. By eating the right foods and adopting a new exercise approach, any man at any age can transform his life by starting a positive chain reaction: Raise T levels through the strategies in this book, improve workouts, get stronger, improve workouts even more, get even stronger, and enable the body to use muscle to process sugar--instead of storing it as fat. Testosterone Transformation is a life-changer: a serious exercise and strategic diet plan that uses the science of a man's own body to help him recharge his sex drive, increase vitality, and reduce health risks across the board.

Testosterone makes us stronger, happier, and smarter. It also makes us meaner, more violent and more selfish. A scientific look into the vast and unexpected influence testosterone has on our behavior, our society, and our bodies. The brain of every man—and every woman—is shaped by this tiny molecule from before birth: it propels our drive for exploration and risk, for competition and creation, and even our survival. The effects of testosterone permeate the traditions, philosophy, and literature of every known culture—without it, the world would be a drastically different place. Testosterone also has a role in humanity's darker side, contributing to violence, hubris, poverty, crime, and selfishness. Recent revelations of the science of testosterone show that high levels will deplete compassion and generosity, and even reduce the affection we show our children. In The Virility Paradox, internationally renowned oncologist and prostate cancer researcher Charles Ryan explores this complex chemical system responsible for a diverse spectrum of human behaviors and health in both men and women. Ryan taps his vast experience treating prostate cancer with testosterone-lowering therapy, observing that this often leads to profound changes in the patients' perspectives on their lives and relationships. Often, for the better. Ryan uses the journeys of these patients and others to illustrate the vast and sometimes unexpected influence testosterone has on human lives. Through the stories of real men and women, he also explores the connections between testosterone and conditions like dementia, autism, and cancer, as well as the biological underpinnings of sexual assault and the effects it has on everything from crime to investing to everyday choices we make. Integrating the molecular and the medical, sociology and storytelling, The Virility Paradox;offers a fascinating look at how one hormone has shaped history, and the connections between our biology, our behavior, and our best selves.

The pituitary, albeit a small gland, is known as the "master gland" of the endocrine system and contributes to a wide spectrum of disorders, diseases, and syndromes. Since the publication of the second edition of The Pituitary, in 2002, there have been major advances in the molecular biology research of pituitary hormone production and action and there is now a better understanding of the pathogenesis of pituitary tumors and clinical syndromes resulting in perturbation of pituitary function. There have also been major advances in the clinical management of pituitary disorders. Medical researchers and practitioners now better understand the morbidity and mortality associated with pituitary hormone hyposecretion and hypersecretion. Newly developed drugs, and improved methods of delivering established drugs, are allowing better medical management of acromegaly and prolactinoma. These developments have improved the worldwide consensus around the definition of a "cure" for pituitary disease, especially hormone hypersecretion, and hence will improve the success or lack of success of various forms of therapy. It is therefore time for a new edition of The Pituitary. The third edition will continue to be divided into sections that summarize normal hypothalamic-pituitary development and function, hypothalamic-pituitary failure, and pituitary tumors; additional sections will describe pituitary disease in systemic disorders and diagnostic procedures, including imaging, assessment of the eyes, and biochemical testing. The first chapter will be completely new – placing a much greater emphasis on physiology and pathogenesis. Two new chapters will be added on the Radiation and Non-surgical Management of the Pituitary and Other Pituitary Lesions. Other chapters will be completely updated and many new author teams will be invited. The second edition published in 2002 and there have been incredible changes in both the research and clinical aspects of the pituitary over the past 8 years – from new advances in growth hormones to pituitary tumor therapy. - Presents a comprehensive, translational source of information about the pituitary in one reference work - Pituitary experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches - Clear presentation by endocrine researchers of the cellular and molecular mechanisms underlying pituitary hormones and growth factors as well as new techniques used in detecting lesions (within the organ) and other systemic disorders - Clear presentation by endocrinologists and neuroendocrine surgeons of how imaging, assessment of the eyes, and biochemical testing can lead to new therapeutic approaches

The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity” to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.

You should know up front that his book might cause you to reevaluate your life. It might influence you to quit your job and switch careers. You might start to look at your relationships in a different way. Hell, it might even cause you to realize that youre not in a good marriage. Thats not just hyperbole, either. T. C. Luomas popular weekly columnthe best of which are featured here in The Testosterone Principles 2: Manhood and Other Stuffhas elicited exactly such potentially life-changing thoughts from the people who regularly read his work. He doesnt preach or rap you on the knuckles. Instead, he shows you glimpses of what lifeyour lifecould and maybe should look like. If youve got even a speck of self-awareness, you end up asking yourself, Hey, is he talking about me? His observations, liberally backed up with science and spiced up with quirky references to popular culture, serve as a guide to the weird, conflicted, often horribly flawed creature called man.

Learn how naturally boosting your testosterone can transform every area of your life If your journey has taken you to this book chances are you want to find information about how to naturally increase your testosterone but without the use of drugs or unnatural medicines doctor can prescribe these days This book has been written because living with low testosterone is not a good way for any man to live but the good news is that low testosterone can be treated with a change of lifestyle and some useful tips and information that will have a massive impact on any man's life This book will guide you through what will increase testosterone and also the things you will want to avoid that will rob you of this precious hormone that can truthfully bring so many benefits both physically and mentally to you Here is a preview of what you will learn in this book What is Testosterone The signs and causes of low testosterone Benefits of Increasing Testosterone Symptoms of High Testosterone Foods to Skyrocket Testosterone Testosterone Boosting Exercise Testosterone Killers to Avoid Tongkat Ali Testosterone and Muscle Growth Conclusion