This is an open access title available under the terms of a CC BY-NC 4.0 International licence. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. Before new interventions are released into disease control programmes, it is essential that they are carefully evaluated in field trials'. These may be complex and expensive undertakings, requiring the follow-up of hundreds, or thousands, of individuals, often for long periods. Descriptions of the detailed procedures and methods used in the trials that have been conducted have rarely been published. A consequence of this, individuals planning such trials have few guidelines available and little access to knowledge accumulated previously, other than their own. In this manual, practical issues in trial design and conduct are discussed fully and in sufficient detail, that Field Trials of Health Interventions may be used as a toolbox' by field investigators. It has been compiled by an international group of over 30 authors with direct experience in the design, conduct, and analysis of field trials in low and middle income countries and is based on their accumulated knowledge and experience. Available as an open access book via Oxford Medicine Online, this new edition is a comprehensive revision, incorporating the new developments that have taken place in recent years with respect to trials, including seven new chapters on subjects ranging from trial governance, and preliminary studies to pilot testing.

Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research-from funders, to researchers, to journals, to physicians, and ultimately, to patients.

Discussing the latest processes involved in researching yield generation, Wheat: Ecology and Physiology of Yield Determination will help you design various types of crop production systems for maximum yield. Featuring information on developing high-yielding, low-input, and quality-oriented systems, this book offers you both physiological and ecological approaches that will help you understand the crop as well as increase its production. Discussing aspects of wheat growth for specific regions around the world, Wheat provides you with information that will improve the size and quality of your crops, including: how temperature, vernalization, and the photoperiod affect the development of wheat using the correct amount of nitrogen fertilizers for wheat crops an explanation of the reproduction and nitrogen cycles of wheat how elements and conditions such as lipids, proteins, nitrogen, and climate enhance grain quality estimating and determining optimal sowing dates examining factors that may affect wheat yield-density relationships, such as planting arrangement and date of sowing preventing seed decay and examining effects of mildews and leaf blights examining historical trends of the crop to see what further research needs to be done You'll also receive information on the genetic gains in wheat research that are improving the physiological traits and numerical components of this essential grain. Within Wheat, you'll find data and methods from international experts in the field that will improve the yield and growth of the world's most important crop.

The papers in this book are organized as follows: insect-plant communities, host-plant selection, genetics and evolution, host-plant resistance and application of transgenic plants, and multitrophic interactions. Besides seven invited papers and a paper with concluding remarks, this volume also contains the short communications of all 115 oral presentations and posters. Included too, are the summaries of four European Science Foundation workshops held over the past two years, where European scientists discussed the state-of-the-art and the future of major topics in insect-plant interactions in order to develop better integrated research programs. The field of insect-plant interactions nowadays includes almost all of biology, as well as parts of chemistry and physics. It takes a central position in biology because insects are the most abundant animal group, half of them are herbivores and they dominate all terrestrial ecosystems. Knowledge of insect-plant interactions is thus fundamental to an understanding of the evolution of life on Earth. Two major topics of worldwide concern give this field an extra dimension. First, large amounts of food crops are still lost due to insect pests. With the increasing concern for environmental pollution and the subsequent plans to drastically reduce pesticides, integrated pest management and development of resistant crops become a major focus in agriculture. The importance of the study of insect-plant relationships is thus continuously augmented. Clearly, successful pest control demands sufficient fundamental knowledge of pest-host interactions. Second, such work can contribute towards stopping or even counterbalancing the threatening biodiversity crisis thanks to an understanding of how the interaction of insects and plants has influenced and still influences the diversification and speciation (evolution) of both groups. These problems should, of course, be approached at a multitrophic level.

Data Analysis Methods in Physical Oceanography is a practical referenceguide to established and modern data analysis techniques in earth and oceansciences. This second and revised edition is even more comprehensive with numerous updates, and an additional appendix on 'Convolution and Fourier transforms'. Intended for both students and established scientists, the fivemajor chapters of the book cover data acquisition and recording, dataprocessing and presentation, statistical methods and error handling,analysis of spatial data fields, and time series analysis methods. Chapter 5on time series analysis is a book in itself, spanning a wide diversity oftopics from stochastic processes and stationarity, coherence functions,Fourier analysis, tidal harmonic analysis, spectral and cross-spectralanalysis, wavelet and other related methods for processing nonstationarydata series, digital filters, and fractals. The seven appendices includeunit conversions, approximation methods and nondimensional numbers used ingeophysical fluid dynamics, presentations on convolution, statisticalterminology, and distribution functions, and a number of importantstatistical tables. Twenty pages are devoted to references. Featuring:• An in-depth presentation of modern techniques for the analysis of temporal and spatial data sets collected in oceanography, geophysics, and other disciplines in earth and ocean sciences.• A detailed overview of oceanographic instrumentation and sensors - old and new - used to collect oceanographic data.• 7 appendices especially applicable to earth and ocean sciences ranging from conversion of units, through statistical tables, to terminology and non-dimensional parameters. In praise of the first edition: "(...)This is a very practical guide to the various statistical analysis methods used for obtaining information from geophysical data, with particular reference to oceanography(...)The book provides both a text for advanced students of the geophysical sciences and a useful reference volume for researchers." Aslib Book Guide Vol 63, No. 9, 1998 "(...)This is an excellent book that I recommend highly and will definitely use for my own research and teaching." EOS Transactions, D.A. Jay, 1999 "(...)In summary, this book is the most comprehensive and practical source of information on data analysis methods available to the physical oceanographer. The reader gets the benefit of extremely broad coverage and an excellent set of examples drawn from geographical observations." Oceanography, Vol. 12, No. 3, A. Plueddemann, 1999 "(...)Data Analysis Methods in Physical Oceanography is highly recommended for a wide range of readers, from the relative novice to the experienced researcher. It would be appropriate for academic and special libraries." E-Streams, Vol. 2, No. 8, P. Mofjelf, August 1999