Thrombotic thrombocytopenic purpura (TTP) is a rare disorder of the blood coagulation system. In most cases, a lack of the ADAMTS13 enzyme leads to an accumulation of ultra-large von Willebrand factor molecules in the plasma which, in turn, initiate the formation of microscopic thromboses in small blood vessels. TTP is a medical emergency. Timely diagnosis and urgent and effective management are vital – mortality in those untreated is in the region of 90%. The understanding of TTP pathogenesis has increased markedly in recent decades. It is now known that TTP is acquired (immunemediated) or congenital, and that the most common type – the acquired form – predominantly affects women in their 40s. It is also clear that the prompt delivery of plasma exchange saves lives. 'Fast Facts: Thrombotic Thrombocytopenic Purpura' sets out, in a clear and accessible format, the steps to suspecting, diagnosing and treating this potentially devastating disease. These steps are complemented by clear descriptions of the disease mechanism and epidemiology. Differential diagnosis, which is of the utmost importance for this disease, is explored in detail. Contents: • Disease overview • Clinical presentation • Differential diagnosis • Laboratory findings and diagnosis • Management

The fourth edition of Facts for Life contains essential information that families and communities need to know to raise healthy children. This handbook provides practical advice on pregnancy, childbirth, childhood illnesses, child development and the care of children. This edition also features a new chapter on child protection. The book is intended for parents, families, health workers, teachers, youth groups, women's groups, community organisations, government officials, employers, trade unions, media, and non-governmental and faith-based organisations.

From weaker to stronger rhetoric : literature - Laboratories - From weak points to strongholds : machines - Insiders out - From short to longer networks : tribunals of reason - Centres of calculation.

The best organizations have the best talent. . . Financial incentives drive company performance. . . Firms must change or die. Popular axioms like these drive business decisions every day. Yet too much common management “wisdom” isn’t wise at all—but, instead, flawed knowledge based on “best practices” that are actually poor, incomplete, or outright obsolete. Worse, legions of managers use this dubious knowledge to make decisions that are hazardous to organizational health. Jeffrey Pfeffer and Robert I. Sutton show how companies can bolster performance and trump the competition through evidence-based management, an approach to decision-making and action that is driven by hard facts rather than half-truths or hype. This book guides managers in using this approach to dismantle six widely held—but ultimately flawed—management beliefs in core areas including leadership, strategy, change, talent, financial incentives, and work-life balance. The authors show managers how to find and apply the best practices for their companies, rather than blindly copy what seems to have worked elsewhere. This practical and candid book challenges leaders to commit to evidence-based management as a way of organizational life—and shows how to finally turn this common sense into common practice.

In this volume, Carolina Sartorio makes the case for big-picture causalism: a naturalistic conception of agency and free agency that unifies the two phenomena under a common thesis. This is the thesis that actions/free actions are behaviors that have the right kinds of causes or explanations. The book discusses how a causalist view of action and free action fit together--the latter as a natural extension of the former--and how they are motivated by similar considerations having to do with causal control. The result is a compelling "package deal" view of our practical agency, one that is put forth as the default view (the view that deserves to be regarded as the starting point of our theorizing). Sartorio examines both the skeleton of the causalist view as well as potential enrichments that result from exploiting the grounds of the relevant causal facts. The discussion is enriched by an account of the role played in causalism by key metaphysical notions such as causation, grounding, absences, and powers.

In the United States, some populations suffer from far greater disparities in health than others. Those disparities are caused not only by fundamental differences in health status across segments of the population, but also because of inequities in factors that impact health status, so-called determinants of health. Only part of an individual's health status depends on his or her behavior and choice; community-wide problems like poverty, unemployment, poor education, inadequate housing, poor public transportation, interpersonal violence, and decaying neighborhoods also contribute to health inequities, as well as the historic and ongoing interplay of structures, policies, and norms that shape lives. When these factors are not optimal in a community, it does not mean they are intractable: such inequities can be mitigated by social policies that can shape health in powerful ways. Communities in Action: Pathways to Health Equity seeks to delineate the causes of and the solutions to health inequities in the United States. This report focuses on what communities can do to promote health equity, what actions are needed by the many and varied stakeholders that are part of communities or support them, as well as the root causes and structural barriers that need to be overcome.

This book analyzes Talcott Parsons’ largest-scale effort to overcome the relativism and subjectivism of the social sciences. Harold J. Bershady sets forth Parsons’ version of the characteristics desirable for social knowledge, showing that Parsons deems the relativistic and subjectivistic arguments as powerful challenges to the validity of social knowledge. Bershady maintains that all Parsons’ intellectual labors exhibit a deep and abiding concern for social knowledge. From his first major work in the 1930s to his later writings on social evolution, Parsons’ theoretical aim has been to provide an unassailable answer to the question, "how is social knowledge possible?" Ideological criticisms of Parsons’ work, Bershady argues, not only miss his awareness of ideological influences upon social thought, but also miss the logical and epistemological strands of his thinking. This book sheds light on the persistent importance of the work of a major theoretical sociologist of the twentieth century. It also brings into the open and discusses issues of deepest concern to the philosophy and methodology of all of the social sciences.

For the first time, Norris gives readers not only his favorite "facts about himself, but also the stories behind the facts and the code by which he lives his life.