This book gives a comprehensive introduction to exponential family nonlinear models, which are the natural extension of generalized linear models and normal nonlinear regression models. The differential geometric framework is presented for these models and geometric methods are widely used in this book. This book is ideally suited for researchers in statistical interfaces and graduate students with a basic knowledge of statistics.

Here we present a nearly complete treatment of the Grand Universe of linear and weakly nonlinear regression models within the first 8 chapters. Our point of view is both an algebraic view as well as a stochastic one. For example, there is an equivalent lemma between a best, linear uniformly unbiased estimation (BLUUE) in a Gauss-Markov model and a least squares solution (LESS) in a system of linear equations. While BLUUE is a stochastic regression model, LESS is an algebraic solution. In the first six chapters we concentrate on underdetermined and overdeterimined linear systems as well as systems with a datum defect. We review estimators/algebraic solutions of type MINOLESS, BLIMBE, BLUMBE, BLUUE, BIQUE, BLE, BIQUE and Total Least Squares. The highlight is the simultaneous determination of the first moment and the second central moment of a probability distribution in an inhomogeneous multilinear estimation by the so called E-D correspondence as well as its Bayes design. In addition, we discuss continuous networks versus discrete networks, use of Grassmann-Pluecker coordinates, criterion matrices of type Taylor-Karman as well as FUZZY sets. Chapter seven is a speciality in the treatment of an overdetermined system of nonlinear equations on curved manifolds. The von Mises-Fisher distribution is characteristic for circular or (hyper) spherical data. Our last chapter eight is devoted to probabilistic regression, the special Gauss-Markov model with random effects leading to estimators of type BLIP and VIP including Bayesian estimation. A great part of the work is presented in four Appendices. Appendix A is a treatment, of tensor algebra, namely linear algebra, matrix algebra and multilinear algebra. Appendix B is devoted to sampling distributions and their use in terms of confidence intervals and confidence regions. Appendix C reviews the elementary notions of statistics, namely random events and stochastic processes. Appendix D introduces the basics of Groebner basis algebra, its careful definition, the Buchberger Algorithm, especially the C. F. Gauss combinatorial algorithm.

This book provides numerous examples of linear and nonlinear model applications. Here, we present a nearly complete treatment of the Grand Universe of linear and weakly nonlinear regression models within the first 8 chapters. Our point of view is both an algebraic view and a stochastic one. For example, there is an equivalent lemma between a best, linear uniformly unbiased estimation (BLUUE) in a Gauss–Markov model and a least squares solution (LESS) in a system of linear equations. While BLUUE is a stochastic regression model, LESS is an algebraic solution. In the first six chapters, we concentrate on underdetermined and overdetermined linear systems as well as systems with a datum defect. We review estimators/algebraic solutions of type MINOLESS, BLIMBE, BLUMBE, BLUUE, BIQUE, BLE, BIQUE, and total least squares. The highlight is the simultaneous determination of the first moment and the second central moment of a probability distribution in an inhomogeneous multilinear estimation by the so-called E-D correspondence as well as its Bayes design. In addition, we discuss continuous networks versus discrete networks, use of Grassmann–Plucker coordinates, criterion matrices of type Taylor–Karman as well as FUZZY sets. Chapter seven is a speciality in the treatment of an overjet. This second edition adds three new chapters: (1) Chapter on integer least squares that covers (i) model for positioning as a mixed integer linear model which includes integer parameters. (ii) The general integer least squares problem is formulated, and the optimality of the least squares solution is shown. (iii) The relation to the closest vector problem is considered, and the notion of reduced lattice basis is introduced. (iv) The famous LLL algorithm for generating a Lovasz reduced basis is explained. (2) Bayes methods that covers (i) general principle of Bayesian modeling. Explain the notion of prior distribution and posterior distribution. Choose the pragmatic approach for exploring the advantages of iterative Bayesian calculations and hierarchical modeling. (ii) Present the Bayes methods for linear models with normal distributed errors, including noninformative priors, conjugate priors, normal gamma distributions and (iii) short outview to modern application of Bayesian modeling. Useful in case of nonlinear models or linear models with no normal distribution: Monte Carlo (MC), Markov chain Monte Carlo (MCMC), approximative Bayesian computation (ABC) methods. (3) Error-in-variables models, which cover: (i) Introduce the error-in-variables (EIV) model, discuss the difference to least squares estimators (LSE), (ii) calculate the total least squares (TLS) estimator. Summarize the properties of TLS, (iii) explain the idea of simulation extrapolation (SIMEX) estimators, (iv) introduce the symmetrized SIMEX (SYMEX) estimator and its relation to TLS, and (v) short outview to nonlinear EIV models. The chapter on algebraic solution of nonlinear system of equations has also been updated in line with the new emerging field of hybrid numeric-symbolic solutions to systems of nonlinear equations, ermined system of nonlinear equations on curved manifolds. The von Mises–Fisher distribution is characteristic for circular or (hyper) spherical data. Our last chapter is devoted to probabilistic regression, the special Gauss–Markov model with random effects leading to estimators of type BLIP and VIP including Bayesian estimation. A great part of the work is presented in four appendices. Appendix A is a treatment, of tensor algebra, namely linear algebra, matrix algebra, and multilinear algebra. Appendix B is devoted to sampling distributions and their use in terms of confidence intervals and confidence regions. Appendix C reviews the elementary notions of statistics, namely random events and stochastic processes. Appendix D introduces the basics of Groebner basis algebra, its careful definition, the Buchberger algorithm, especially the C. F. Gauss combinatorial algorithm.

Nonlinear measurement data arise in a wide variety of biological and biomedical applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the analysis of assay and laboratory data. Nonlinear Models for Repeated Measurement Data provides the first unified development of methods and models for data of this type, with a detailed treatment of inference for the nonlinear mixed effects and its extensions. A particular strength of the book is the inclusion of several detailed case studies from the areas of population pharmacokinetics and pharmacodynamics, immunoassay and bioassay development and the analysis of growth curves.

Most biologists use nonlinear regression more than any other statistical technique, but there are very few places to learn about curve-fitting. This book, by the author of the very successful Intuitive Biostatistics, addresses this relatively focused need of an extraordinarily broad range of scientists.

This monograph provides an up-to-date discussion of analysis strategies for regression problems in which predictor variables are measured with errors. The analysis of nonlinear regression models includes generalized linear models, transform-both-sides models and quasilikelihood and variance function problems. The text concentrates on the general ideas and strategies of estimation and inference rather than being concerned with a specific problem. Measurement error occurs in many fields, such as biometry, epidemiology and economics. In particular, the book contains a large number of epidemiological examples. An outline of strategies for handling progressively more difficult problems is also provided.

Integrates the latest theory, methodology and applications related to the design and analysis of repeated measurement. The text covers a broad range of topics, including the analysis of repeated measures design, general crossover designs, and linear and nonlinear regression models. It also contains a 3.5 IBM compatible disk, with software to implem

Differential geometry provides an aesthetically appealing and oftenrevealing view of statistical inference. Beginning with anelementary treatment of one-parameter statistical models and endingwith an overview of recent developments, this is the first book toprovide an introduction to the subject that is largely accessibleto readers not already familiar with differential geometry. It alsogives a streamlined entry into the field to readers with richermathematical backgrounds. Much space is devoted to curvedexponential families, which are of interest not only because theymay be studied geometrically but also because they are analyticallyconvenient, so that results may be derived rigorously. In addition,several appendices provide useful mathematical material on basicconcepts in differential geometry. Topics covered include thefollowing: * Basic properties of curved exponential families * Elements of second-order, asymptotic theory * The Fisher-Efron-Amari theory of information loss and recovery * Jeffreys-Rao information-metric Riemannian geometry * Curvature measures of nonlinearity * Geometrically motivated diagnostics for exponential familyregression * Geometrical theory of divergence functions * A classification of and introduction to additional work in thefield

- Coherent and unified treatment of nonlinear regression with R. - Example-based approach. - Wide area of application.