This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues in food. The first part of the report considers general principles regarding the evaluation of residues of veterinary drugs within the terms of reference of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). It covers topics such as the parallel review process; estimation of dietary exposure to veterinary drug residues; a risk-based decision tree approach for safety evaluation; assessment of the potential effects of residues on the human intestinal microbiome. Summaries follow the Committee’s evaluations of toxicological and residue data on a variety of veterinary drugs: two antiparasitic agents (imidacloprid, ivermectin) and one coccidiostat (nicarbazin). Additionally, further evaluation of the parasiticide selamectin is included as part of a pilot in support of the proposed parallel review process. Annexed to the report is a summary of the Committee’s recommendations on these drugs, including acceptable daily intakes and proposed maximum residue limits.

This report represents the conclusions of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) convened to evaluate the safety of veterinary drug residues in food: clopidol, imidacloprid and fumagillin. Annexed to this report is a summary of the Committee’s recommendations on these drugs discussed at the ninety-eighth meeting, including acceptable daily intakes (ADIs), acute reference doses (ARfDs), estimated dietary exposure and proposed maximum residue limits (MRLs). Summaries are also provided for general considerations around the matters of interest arising from previous sessions of the Codex Committee on Residues of Veterinary Drugs in Foods (CCRVDF), update of Guidance for the Safety Evaluation of Residues of Veterinary Drugs with incomplete data packages, and release of JECFA Toolbox for Veterinary Drug Residues Risk Assessment. This volume and others in the WHO Technical Report Series contain infrmation that is useful to those who produce and use veterinary drugs, and those involved with controlling contaminants in food, government and food regulatory officers, industrial testing laboratories, toxicological laboratories and universities.

This volume contains a monograph prepared at the ninety-third meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which met virtually from 24 March–1 April 2022. [Author] The monograph addendum in this volume summarizes the data on a contaminant group (trichothecenes T-2 and HT-2 toxins) discussed at the ninety-third meeting. [Author] This volume and others in the WHO Food Additives series contain information that is useful to those who produce and use food additives and veterinary drugs and those involved with controlling contaminants in food, government and food regulatory officers, industrial testing laboratories, toxicological laboratories and universities. [Author]

This volume of FAO JECFA Monographs contains residue evaluation of certain veterinary drugs prepared at the 98th meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), held from 20 to 29 February 2024. This JECFA meeting was convened specifically to consider residues of veterinary drugs in food-producing animal species. The tasks for the Committee were to further elaborate principles for evaluating the safety of residues of veterinary drugs in food and for establishing acceptable daily intakes (ADIs) and/or acute reference doses (ARfDs), and to recommend maximum residue limits (MRLs) for substances when they are administered to food-producing animals in accordance with good veterinary practice (GVP) in the use of veterinary drugs. The present volume contains monographs on the evaluations of residue data of substances scheduled for evaluation at the request of the Codex Committee on Residues of Veterinary Drugs in Food. A summary of the recommendations on compounds is also presented in this report. The enclosed monographs provided the scientific basis for the recommendations of MRLs.

The monographs contained in this volume were prepared at the ninety-sixth meeting of the Joint Food and Agriculture Organization of the United Nations (FAO)/World Health Organization (WHO) Expert Committee on Food Additives (JECFA), which met at WHO headquarters in Geneva, Switzerland, on 27 June–6 July 2023. [Author] These monographs summarize the data on specific food additives, including flavouring agents, reviewed by the Committee. [Author]

This report presents the conclusions of a Joint FAO/WHO Expert Committee on Food Additives (JECFA), which met virtually from 7 to 18 June 2021. The toxicological and dietary exposure monographs in this volume summarize data on the safety of and dietary exposure to specific food additives: benzoic acid, its salts and derivatives; collagenase from Streptomyces violaceoruber expressed in S. violaceoruber; ¦Â-glucanase from Streptomyces violaceoruber expressed in S. violaceoruber; phospholipase A2 from Stretomyces violaceoruber expressed in S. violaceoruber; riboflavin from Ashbya gossypii; and ribonuclease P from Penicillium citrinum.

The monographs contained in this volume were prepared at the ninety-second meeting of the Joint Food and Agriculture Organization of the United Nations (FAO)/World Health Organization (WHO) Expert Committee on Food Additives (JECFA), which met virtually from 7–18 June 2021. These monographs summarize the data on specific food additives reviewed by the Committee.