Engineering Flesh. Towards professional responsibility for ‘lived bodies’ in Tissue Engineering This study analyses the work of biomedical engineers as normative work that affects people’s daily lives as bodies. In biomedical engineering, engineers study bodies as machine-like objects and develop technologies from such a perspective. However, in daily life patients live their bodies not as machine-like but as themselves. Biomedical engineering can be said to involve normative work because it affects the way people experience and live their bodies. For example, imaging technologies used to follow the development of a foetus during pregnancy stimulate the perception of the foetus as an individual human being and change the related conceptions of good professional care and responsible parenthood. In this light, I raise the question as to how biomedical engineers can take and shape professional responsibility for this kind of normative work with respect to bodies. To study normative work in biomedical engineering, I have analysed the practice of tissue engineering (TE). In this practice, engineers rather literally make human body parts: TE has as objective to create living body part substitutes (e.g. skin, heart valves and bladders) by using cells. In the tradition of Science and Technology Studies (STS) I have studied normative work in TE empirically by following a specific TE project: namely, a TE heart valve project through participant observations, interviews and other fieldwork approaches. To be able to analyse how the practice of TE affects lived bodies I draw on work in the philosophical tradition of phenomenology. This tradition has as central concept ‘the lived body’ rather than the body as object. In this book I show how TE implies normative work for engineers: in the presentation of their work in terms of ‘mimicking nature’; in making standards for TE heart valves; and in developing networks to stimulate the further development of TE and to enable the impleme

This book develops a sociological analysis of the emergence of regenerative medicine, providing critical insights into what it means to 'regenerate bodies'. It examines how human tissues and cells are being exchanged, commodified and commercialized by new health technologies. Through a discussion of emergent global 'tissue economies', the author explores the social dynamics of innovation in the fields of tissue engineering and stem cell science.

This book presents a critical examination of conversations between engineering, social sciences, and the humanities asking whether their conversations have come of age. These conversations are important because ultimately their outcome have real world consequences in engineering education and practice, and for the social and material world we inhabit. Taken together the 21 chapters provide scholarly-argued responses to the following questions. Why are these conversations important for engineering, for social sciences, and for the humanities? Are there key places in practice, in the curriculum, and in institutions where these conversations can develop best? What are the barriers to successful conversations? What proposals can be made for deepening these conversations for the future? How would we know that the conversations have come of age, and who gets to decide? The book appeals to scholarly audiences that come together through their work in engineering education and practice. The chapters of the book probes and access the meetings and conversations, and they explore new avenues for strengthening dialogues that transcend narrow disciplinary confines and divisions. “The volume offers a rich collection of descriptive resources and theoretical tools that will be useful for researchers of engineering practices, and for those aiming to reshape the engineering lifeworld through new policies. The book depicts the current state of the art of the most visible SSH contributions to shaping engineering practices, as well as a map of research gaps and policy problems that still need to be explored.” - Dr. Ir. Lavinia Marin, TU Delft, Electrical Engineering and Philosophy

Today, it is widely recognized that in order to meet environmental challenges, it will not simply be enough to make our lifestyles greener; also critical is putting an end to the modern conception of the human as master and possessor of nature. However, to bear fruit, this change in anthropology must also be accompanied by a revision in our conception of technology. Since the Enlightenment and the development of industrialization, technology no longer seems to be subject to the guiding principles set by the Greeks: prudence and the search for the right measure in all, which leads to the care of beings and the world. Care in Technology analyzes the historical changes that have led technology to become an unthinkable part of care, and care an unthinkable part of technology. It also establishes the conditions for care to once again become a regulatory principle of the activity of engineers who design technology.

Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

How engineered materials and machines powered by living biological cells can tackle technological challenges in medicine, agriculture, and global security. You are a biological machine whose movement is powered by skeletal muscle, just as a car is a machine whose movement is powered by an engine. If you can be built from the bottom up with biological materials, other machines can be as well. This is the conceptual starting point for biofabrication, the act of building with living cells--building with biology in the same way we build with synthetic materials. In this volume in the MIT Press Essential Knowledge series, Ritu Raman offers an accessible introduction to biofabrication, arguing that it can address some of our greatest technological challenges. After presenting the background information needed to understand the emergence and evolution of biofabrication and describing the fundamental technology that enables building with biology, Raman takes deep dives into four biofabrication applications that have the potential to affect our daily lives: tissue engineering, organs-on-a-chip, lab-grown meat and leather, and biohybrid machines. Organs-on-a-chip (devices composed of miniature model tissues), for example, could be used to test new medicine and therapies, and lab-grown meat could alleviate environmental damage done by animal farming. She shows that biological materials have abilities synthetic materials do not, including the ability to adapt dynamically to their environments. Exploring the principles of biofabrication, Raman tells us, should help us appreciate the beauty, adaptiveness, and persistence of the biological machinery that drives our bodies and our world.

This book summarizes the NATO Advanced Research Workshop (ARW) on “Nanoengineered Systems for Regenerative Medicine” that was organized under the auspices of the NATO Security through Science Program. I would like to thank NATO for supporting this workshop via a grant to the co-directors. The objective of ARW was to explore the various facets of regenerative me- cine and to highlight role of the “the nano-length scale” and “nano-scale systems” in defining and controlling cell and tissue environments. The development of novel tissue regenerative strategies require the integration of new insights emerging from studies of cell-matrix interactions, cellular signalling processes, developmental and systems biology, into biomaterials design, via a systems approach. The chapters in the book, written by the leading experts in their respective disciplines, cover a wide spectrum of topics ranging from stem cell biology, developmental biology, ce- matrix interactions, and matrix biology to surface science, materials processing and drug delivery. We hope the contents of the book will provoke the readership into developing regenerative medicine paradigms that combine these facets into cli- cally translatable solutions. This NATO meeting would not have been successful without the timely help of Dr. Ulrike Shastri, Sanjeet Rangarajan and Ms. Sabine Benner, who assisted in the organization and implementation of various elements of this meeting. Thanks are also due Dr. Fausto Pedrazzini and Ms. Alison Trapp at NATO HQ (Brussels, Belgium). The commitment and persistence of Ms.

The recognition and control of hazards in the work environment are the cornerstone of every company’s safety and health plan. Every workplace contains dangers, especially those devoted to technology, machinery, and potentially hazardous material. This book provides you with the information you need to understand the regulations that provide for facility safety and their successful implementation for profitable management of any business. FEATURES Explores both occupational and environmental hazards Describes the workplace threats from machines, confined spaces, chemicals, personnel, cumulative trauma, environmental issues, electricity, noise, fire and explosion, and the risk of falling Provides measures to protect the eyes, the head, the respiratory system, the circulatory system, and more Details common fire protection countermeasures from an experienced firefighter and fire instructor Addresses ladders, scaffolding and OSHA fall protection standards Includes sections on PPE, laser safety, and forklifts