The first book devoted exclusively to the subject, Platelet Rich Fibrin in Regenerative Dentistry offers comprehensive, evidence-based coverage of the biological basis and clinical applications of PRF in dentistry. Co-edited by a leading researcher in tissue regeneration and the inventor of the PRF technique, it brings together original contributions from expert international researchers and clinicians. Chapters cover the biological foundation of PRF before addressing specific uses of the technology within clinical dentistry. Topics describe the use of PRF in many dental applications, including extraction socket management, sinus lifting procedures, root coverage, periodontal regeneration, soft tissue healing around implants, guided bone regeneration, and facial esthetics. The text is supplemented with color photographs and explanatory illustrations throughout. Platelet Rich Fibrin in Regenerative Dentistry: Biological Background and Clinical Indications is an indispensable professional resource for periodontists, oral surgeons and oral and maxillofacial surgeons, as well as general dentists who use PRF or are interested in introducing it into their practices. It is also an excellent reference for undergraduate and postgraduate dental students.

This book will guide clinicians to achieve great results with L-PRF. It starts with basic science chapters on tissue regeneration, blood centrifugation, and an explanation of the biologic power of platelet concentrates. However, the true value of this book lies in an evidence-based evaluation of the benefits of L-PRF in periodontal and maxillofacial surgery, as well as in chronic wound therapy. For each treatment, a step-by-step approach has been created by experienced clinicians. The most crucial steps are explained in 18 videos via augmented reality.

Platelets play an important role in periodontal regeneration as they contain growth factors and cytokines which are essential for bone regeneration and soft tissue maturation. Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are autologous platelet concentrates prepared from patient's own blood. PRF is second generation platelet concentrate which is prepared without any artificial biochemical modification of blood. It is biocompatible, easy to prepare, economical and enriched with platelets and growth factors. This book reviews the properties of PRF and its potential role in periodontal regeneration.

Platelet rich fibrin (PRF) is an autologous biological product which becomes popular day by day and available in a wide variety of fields in medicine. Platelet concentrates which are introduced at the early 90s have evolved over the years. The use such autologous materials have become trendy in recent years to encounter demanding expectations of patients, improve treatment success and maximize patient comfort. Despite its increasing use in dentistry and oral surgery, the most indications and effects are still being discussed. PRF is easily accepted by patients because of its low cost, easy to receive, low donor morbidity, low postoperative complication and infection rate. This biomaterial may be a solution for patients who have strong negative beliefs about the use of allografts and xenografts or who are afraid of complications during the grafting procedure. The objectives of these technologies are to use their synergistic effect to improve the hard and soft tissue regeneration. PRF in oral surgery are used for alveolar bone reconstruction, dental implant surgery, sinus augmentation, socket preservation, osteonecrosis, oroantral fistula closure, struggling with oral ulcers, preventing swelling and edema constitution. This chapter aims to review the clinical applications of platelets in oral surgery and the role of molecular components in tissue healing.

Periodontology explores the molecular status in periodontal disease. Optical devices in the diagnosis and management of the disease are also discussed. The book addresses the role of the oral healthcare provider in interprofessional communication in the systemic management of autoimmune bullous disease-associated conditions. A study involving chemically modified tetracyclines and host modulation with nonsurgical and surgical periodontal therapy, including postoperative pain management, is presented here. Therapeutic strategies of stem cell application in bone tissue engineering and the potential of platelet-rich fibrin-sourced growth factors in periodontal procedures to enhance wound healing and regeneration are also proposed. Supportive implant maintenance and regenerative processes are explored. Management of the endoperiodontal lesion is also discussed (note: the recent periodontal classification has not been referenced here). The book explores the best transdisciplinary practices for the management of special healthcare needs patients.

In this century, there are two mostly practiced techniques for bone regeneration. These are autogenous bone grafting (ABG) and guided bone regeneration (GBR). It was reported in the late 1970s that platelets have a good regenerative effects. Platelets include growth factors that increase vascularization and collagen production by cell mitosis. Recently, most of the studies have indicated that platelet-rich fibrin (PRF) is a great healing potential for bony and soft tissue that derived from patients own blood. Most beneficial effects of PRF are easily derived directly from patient's venous blood without any ingredients, and it has a great potential for hard and soft tissue regeneration. PRF has no inflammatory effects and can be used with all kind of graft materials. When used as a membrane, it helps protecting the surgical area to stimulate the healing of soft and bone tissues.

"This book gathered numerous experts across many fields to collectively provide information on leading esthetic PRF therapies to expand treatment possibilities"--