This book reviews the advances and challenges of structure-based drug design in the preclinical drug discovery process, addressing various diseases, including malaria, tuberculosis and cancer. Written by internationally recognized researchers, this edited book discusses how the application of the various in-silico techniques, such as molecular docking, virtual screening, pharmacophore modeling, molecular dynamics simulations, and residue interaction networks offers insights into pharmacologically active novel molecular entities. It presents a clear concept of the molecular mechanism of different drug targets and explores methods to help understand drug resistance. In addition, it includes chapters dedicated to natural-product- derived medicines, combinatorial drug discovery, the CryoEM technique for structure-based drug design and big data in drug discovery. The book offers an invaluable resource for graduate and postgraduate students, as well as for researchers in academic and industrial laboratories working in the areas of chemoinformatics, medicinal and pharmaceutical chemistry and pharmacoinformatics.

For more than 20 years, Network World has been the premier provider of information, intelligence and insight for network and IT executives responsible for the digital nervous systems of large organizations. Readers are responsible for designing, implementing and managing the voice, data and video systems their companies use to support everything from business critical applications to employee collaboration and electronic commerce.

Since the appearance of simplified 3D sketching programs like SketchUp, architects and interior designers have been called on to use both freehand and 3D CAD drawings, often at very earliest stages of design. Since we must often go back and forth between analytical plan views and 3D visual views, it's important that this be a seamless process, requiring little disruptive action or break in the workflow. Integrated Drawing Techniques closes the gap between creativity and geometry, teaching beginner architects and interior designers how to design their residential interiors using freehand sketching and computer-aided design simultaneously. From concept planning to 3D rendering, this book is a comprehensive guide to designing residences by hand and computer.