Optical coherence tomography (OCT) is a noninvasive, noncontact imaging modality that uses coherent gating to obtain high-resolution cross-sectional images of the microstructure of biological tissues. Recently, OCT has been considered as a promising technique for intravascular imaging, since it provides direct visualization of vessel walls with resolutions of 1-2 orders higher than intravascular ultrasound (IVUS). However, there are two major drawbacks for OCT: limited penetration depth makes it difficult to image the whole depth of atherosclerotic plaques and clearance of blood is required since the presence of blood can seriously attenuate OCT signals. OCT and ultrasound (US) are complementary in the application of intravascular imaging. This research focuses on the development of an integrated OCT-US system for the application of intravascular imaging. By combining the two imaging modalities, the system is capable of offering simultaneous OCT and ultrasound images in real-time, thus allowing for images with both high resolution and a deep imaging depth which will significantly improve diagnostic accuracy in the detection of atherosclerosis. OCT-US probes that combine OCT optical components and US transducers have been developed. Different probe designs have been realized based on different applications; and the latest version of the miniature design aimed at human coronary artery imaging has a maximum outer diameter of only 0.69mm. A rotary joint that combines a fiber optic rotary joint and electrical slip ring has been developed, so that both optical and electrical signals can be transmitted between the stationary and rotary parts of the system. The integrated imaging system provides real-time simultaneous OCT and US data acquisition, processing and image display by using a single two-channel data acquisition board and a home-developed OCT-US program. In vitro human coronary specimen imaging and in vivo animal studies have been performed to demonstrate the feasibility of our OCT-US system in the application of intravascular imaging. Last but not least, a 3-dimensional high speed endoscopic OCT system has been developed for the application of airway imaging. In vivo animal studies of smoke-induced early airway injury were performed using this system. Image processing software has been successfully developed for motion artifact removal, image reconstruction and quantitative analysis of airway thickness.

Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.

Ultrasound imaging is one of the most important and widely used diagnostic tools in modern medicine, second only to the conventional x-ray. Although considered a mature field, research continues for improving the capabilities and finding new uses for ultrasound technology while driving down the cost of newer, more complicated procedures such as int

Since the early 1960's, the field of medical imaging has experienced explosive growth due to the development of three new imaging modalities-radionuclide imaging, ultrasound, and magnetic resonance imaging. Along with X-ray, they are among the most important clinical diagnostic tools in medicine today. Additionally, the digital revolution has played a major role in this growth, with advances in computer and digital technology and in electronics making fast data acquisition and mass data storage possible. This text provides an introduction to the physics and instrumentation of the four most often used medical imaging techniques. Each chapter includes a discussion of recent technological developments and the biological effects of the imaging modality. End-of-chapter problem sets, lists of relevant references, and suggested further reading are presented for each technique. - X-ray imaging, including CT and digital radiography - Radionuclide imaging, including SPECT and PET - Ultrasound imaging - Magnetic resonance imaging

This book focuses on the coronary bioresorbable scaffold, a new interventional treatment for coronary artery disease, differentiated from a permanent metallic stent. The book provides an overview of the technology including non-clinical studies and clinical evidences in order to help clinicians understand the appropriate application of the technology and the optimal techniques of implantation. It covers the basics of bioresorbable scaffolds; bench test results; preclinical studies; clinical evidences; and tips and tricks of implantation.

This book provides a state-of-the-art overview of the combined use of imaging modalities to obtain important functional and morphological information on intravascular disease and enhance disease detection. It discusses the integration of intravascular ultrasound (IVUS, intravascular optical coherence tomography (OCT), intravascular photoacoustic imaging (IVPA) and acoustic radiation force optical coherence elastography (ARF-OCE), and introduces the integration of multimodality imaging systems, such as IR and florescence. It includes the latest research advances and numerous imaging photos to offer readers insights into current intravascular applications. It is a valuable resource for students, scientists and physicians wanting to gain a deeper understanding of multimodality imaging tools.

Computing and Visualization for Intravascular Imaging and Computer-Assisted Stenting presents imaging, treatment, and computed assisted technological techniques for diagnostic and intraoperative vascular imaging and stenting. These techniques offer increasingly useful information on vascular anatomy and function, and are poised to have a dramatic impact on the diagnosis, analysis, modeling, and treatment of vascular diseases. After setting out the technical and clinical challenges of vascular imaging and stenting, the book gives a concise overview of the basics before presenting state-of-the-art methods for solving these challenges. Readers will learn about the main challenges in endovascular procedures, along with new applications of intravascular imaging and the latest advances in computer assisted stenting. - Brings together scientific researchers, medical experts, and industry partners working in different anatomical regions - Presents an introduction to the clinical workflow and current challenges in endovascular Interventions - Provides a review of the state-of-the-art methodologies in endovascular imaging and their applications - Poses outstanding questions and discusses future research

Optical Coherence Tomography gives a broad treatment of the subject which will include 1)the optics, science, and physics needed to understand the technology 2) a description of applications with a critical look at how the technology will successfully address actual clinical need, and 3) a discussion of delivery of OCT to the patient, FDA approval and comparisons with available competing technologies. The required mathematical rigor will be present where needed but be presented in such a way that it will not prevent non-scientists and non-engineers from gaining a basic understanding of OCT and the applications as well as the issues of bringing the technology to the market. - Optical Coherence Tomography is a new medical high-resolution imaging technology which offers distinct advantages over current medical imaging technologies and is attracting a large number of researchers. - Provides non-scientists and non-engineers basic understanding of Optical Coherence Tomography applications and issues.

Expert guidance from internationally recognized authorities, who provide clear and current updates on all aspects of interventional cardiology. This new edition; Contains a radically expanded chapter contents list presented in four clear sections; coronary interventions, interventional pharmacology, structural heart interventions, and endovascular therapy Includes 46 new chapters, including the latest advances in bioresorbable coronary stents, advanced transcatheter aortic valve replacement, MitraClip, new transcatheter mitral valve interventions, and more Chapters are templated for rapid referral, beginning with pathophysiological background and relevant pathology, moving to mechanisms of treatment, device description, procedural techniques, follow-up care, and ending with risks, contraindications and complications Multiple choice questions at the end of each chapter for self-assessment, a total of more than 400 MCQs in the book Features 19 procedural videos, hosted on a companion website

This heavily revised second edition comprehensively reviews the use of optical coherence tomography (OCT) in cardiovascular practice. It provides detailed guidance on how to properly interpret OCT images and successfully utilise it in daily clinical practice Chapters cover the development and physics associated with OCT, relevant interpretation skills, OCT imaging artifacts, plaque erosion, bioabsorbable stent, the detection of vulnerable plaque, and the use of OCT imaging in unison with other modalities such as phase contrast imaging (PCI). Areas of potential future development are also covered Cardiovascular OCT Imaging enables interventional cardiologists and cardiologists to quickly become both familiar and develop a detailed understanding of this technology to improve patient care and treatment outcome. It is a valuable reference for all practising and trainee medical professionals in cardiology, and in particular those who specialize in interventional cardiology.