Continued geographic expansion of dengue viruses and their mosquito vectors has seen the magnitude and frequency of epidemic dengue/dengue hemorrhagic fever (DF/DHF) increase dramatically. Recent exciting research on dengue has resulted in major advances in our understanding of all aspects of the biology of these viruses, and this updated second edition brings together leading research and clinical scientists to review dengue virus biology, epidemiology, entomology, therapeutics, vaccinology and clinical management.

This publication is intended to contribute to prevention and control of the morbidity and mortality associated with dengue and to serve as an authoritative reference source for health workers and researchers. These guidelines are not intended to replace national guidelines but to assist in the development of national or regional guidelines. They are expected to remain valid for five years (until 2014), although developments in research could change their validity.--Publisher's description.

THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.

Dengue and its potentially fatal forms, dengue henorrhagic fever and dengue shock syndrome, once more threaten much of the Americas. In the 1980s the vector control programmes fell victim to the cutbacks in public health expenditure and their responses to dengue outbreaks tended to be a little too late. These guidelines have risen to the challenge by incorporating all aspects of the prevention and control of the disease and its vectors. In addition, because dengue is primarily a problem of domestic sanitation and households can combat the problem inexpensively. The guidelines enmphasize ways to transfer responsibility for dengue control and prevention to the community."

2. Virological Findings. 90 3. Immunity. . . . . 90 C. Secondary Dengue: Dengue Hemorrhagic Fever and the Shock Syndrome 92 1. General Remarks. . . . . . . . . . . . . . 92 2. Clinical Course and Clinical Laboratory Findings 93 3. Virological and Serological Findings. . . 95 4. Immunopathology of Secondary Dengue. 98 XI. Immunization. . . . . . . . . . . . . . . 104 A. Anamnestic Immune Responses in Sequential Infections With Dengue and Other Group B Togaviruses . . . . . . . . 104 1. Results With Members of the Dengue Subgroup 104 2. Results With Dengue and Other Flaviviruses. 107 B. Dengue Vaccines for Use in Man 108 XII. Opportunities for the Future 113 Acknowledgments. 114 References. . . . . . . . . . . 114 I. Introduction Dengue fever is a mosquito-transmitted disease of man which has afflicted untold millions of people over the past two centuries. It is caused by viruses classified as a subgroup of the group B togaviruses. Along with other members of that group as well as group A, the dengue viruses have been investigated intensively during recent years. Certain unique aspects of their structure, composition, antigenicity, replication, and antigenic relationships have established the togavirus family as quite distinct from other families of enveloped RNA viruses (see recent review of PFEFFERKORN and SHAPIRO, 1974). The basic studies leading to this conclusion have coincided with epidemiological field investigations which have resulted in a continuing increase in the number of viruses now designated as group A or B togaviruses. This, in turn, has led to a growing appreciation of their immense importance as actual or potential pathogens of man and beast.

This unique volume presents an up-to-date review of one of the world's major health problems -- diseases caused by the four dengue viruses. It begins with an insightful story of the origin of dengue disease outbreaks, including the emergence of severe and fatal dengue hemorrhagic fever. The nature, structure and biology of the four dengue viruses are described, and a major portion of the book is focused on the epidemiology of dengue as a mosquito-borne disease. This is complemented by critiques of existing mosquito control programs by three groups of outstanding authorities. The strongest element of the volume is its comprehensive description of the current understanding of dengue disease pathogenesis, followed by an analysis of the pros and cons of five of the most controversial areas in the field: the WHO DEF case definition, secondary dengue infections, virulent viruses, the role of abnormal T cells and autoimmunity.

Dengue fever is an infectious disease found around the world that is caused by four closely related, but distinct, types of viruses commonly transmitted by Aedes aegypti mosquitoes. Triggering excessive bleeding, dengue fever, dengue hemorrhagic fever, and dengue hemorrhagic shock can be fatal. Dengue Fever and Other Hemorrhagic Viruses explores the biology of the dengue virus and similar viruses such as Ebola, Marburg virus, and Lassa fever, as well as their symptoms, where they are commonly found, how they are transmitted, and the efforts to treat and eradicate them.Chapters include: Ins and Outs of Dengue; Hemorrhagic Fevers; Vectors - Bugs That Carry Disease; The Immune System: Our Line of Defense; and, Vaccination - Waking Up the Army in Us.

Dengue is an endemic viral disease affecting human population in tropical and subtropical regions around the world, predominantly in urban and semi-urban areas. Dengue fever (DF) and its more serious forms, the dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) are becoming important public health problems. The global prevalence of dengue has grown dramatically in recent decades. An estimated 2.5 billion people in more than 100 countries are at risk of acquiring dengue viral infection with more than 50 million new infections being projected annually, between 20,000 and 25,000 deaths, mainly in children. This book aims to review the possible molecular mechanisms that attribute to the variation of Dengue virus (DENV) disease. Additionally, a description of the animal models that have been developed to study DENV pathogenesis and to test potential vaccines and therapeutics are reviewed. This book also reviews the current understanding of DENV pathogenesis and the challenges confronting vaccine and therapeutic developers. Other chapters in this book examine the responses of target cells, including dendritic cells in people infected with DENV, recent developments in the molecular diagnosis for dengue virus, the mathematical models on dengue transmission and control, and a discussion of the ways in which to prevent and control dengue outbreaks.