Time delayed (lagged) variables are an inherent feature of biological/physiological systems. For example, infection from a disease may at first be asymptomatic, and only after a delay is the infection apparent so that treatment can begin.Thus, to adequately describe physiological systems, time delays are frequently required and must be included in the equations of mathematical models. The intent of this book is to present a methodology for the formulation and computer implementation of mathematical models based on time delay ordinary differential equations (DODEs) and partial differential equations (DPDEs). The DODE/DPDE methodology is presented through a series of example applications, particularly in biomedical science and engineering (BMSE). The computer-based implementation of the example models is explained with routines coded (programmed) in R, a quality, open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized, e.g., no theorems and proofs. Rather, the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers. The DPDE analysis is based on the method of lines (MOL), an established general algorithm for PDEs, implemented with finite differences. The example applications can first be executed to confirm the reported solutions, then extended by variation of the parameters and the equation terms, and even the forumulation and use of alternative DODE/DPDE models. • Introduces time delay ordinary and partial differential equations (DODE/DPDEs) and their numerical computer-based integration (solution) • Illustrates the computer implementation of DODE/DPDE models with coding (programming) in R, a quality, open-source scientific programming system readily available from the Internet • Applies DODE/DPDE models to biological/physiological systems through a series of examples • Provides the R routines for all of the illustrative applications through a download link • Facilitates the use of the models with reasonable time and effort on modest computers

This book is intended to be an introduction to Delay Differential Equations for upper level undergraduates or beginning graduate mathematics students who have a reasonable background in ordinary differential equations and who would like to get to the applications quickly. The author has used preliminary notes in teaching such a course at Arizona State University over the past two years. This book focuses on the key tools necessary to understand the applications literature involving delay equations and to construct and analyze mathematical models involving delay differential equations. The book begins with a survey of mathematical models involving delay equations.

Provides exact solutions Describes numerical methods or numerical solutions, analytical methods, stability/instability issues Focus on partial differential equations

This textbook is designed for the intermediate-level course on ordinary differential equations offered at many universities and colleges. It treats, as standard topics of such a course: existence and uniqueness theory, linear s- terns, stability theory, and introductory phase-plane analysis of autonomous second order systems. The unique feature of the book is its further inc- sion of a substantial introduction to delay differential eq- tions. Such equations are motivated by problems in control theory, physics, biology, ecology, economics, inventory c- trol, and the theory of nuclear reactors. The surge of interest in delay differential equations during the past two or three decades is evidenced by th- sands of research papers on the subject and about 20 published books devoted in whole or in part to these equations. The v * ... books include those of Myskis [1951], El' sgol' c [1955] and [1964], Pinney [1958], Krasovskil [1959], Bellman and Cooke [1963], Norkin [1965], Halanay [1966], Oguztoreli [1966], Lakshmikantham and Leela [1969], Mitropol'skir and Martynjuk [1969], Martynjuk [1971], and Hale [1971], plus a number of symposium and seminar proceedings published in the U.S. and the U.S.S.R. These books have influenced the present textbook.

Provides exact solutions Describes numerical methods or numerical solutions, analytical methods, stability/instability issues Focus on partial differential equations

With neutral differential equations, any lack of smoothness in initial conditions is not damped and so they have proven to be difficult to solve. Until now, there has been little information to help with this problem. Oscillation Theory for Neutral Differential Equations with Delay fills a vacuum in qualitative theory of functional differential equations of neutral type. With much of the presented material previously unavailable outside Eastern Europe, this authoritative book provides a stimulus to research the oscillatory and asymptotic properties of these equations. It examines equations of first, second, and higher orders as well as the asymptotic behavior for tending toward infinity. These results are then generalized for partial differential equations of neutral type. The book also describes the historical development of the field and discusses applications in mathematical models of processes and phenomena in physics, electrical control and engineering, physical chemistry, and mathematical biology. This book is an important tool not only for mathematicians, but also for specialists in many fields including physicists, engineers, and biologists. It may be used as a graduate-level textbook or as a reference book for a wide range of subjects, from radiophysics to electrical and control engineering to biological science.

This unique book describes, analyses, and improves various approaches and techniques for the numerical solution of delay differential equations. It includes a list of available codes and also aids the reader in writing his or her own.

This book presents the authors' recent work on the numerical methods for the stability analysis of linear autonomous and periodic delay differential equations, which consist in applying pseudospectral techniques to discretize either the solution operator or the infinitesimal generator and in using the eigenvalues of the resulting matrices to approximate the exact spectra. The purpose of the book is to provide a complete and self-contained treatment, which includes the basic underlying mathematics and numerics, examples from population dynamics and engineering applications, and Matlab programs implementing the proposed numerical methods. A number of proofs is given to furnish a solid foundation, but the emphasis is on the (unifying) idea of the pseudospectral technique for the stability analysis of DDEs. It is aimed at advanced students and researchers in applied mathematics, in dynamical systems and in various fields of science and engineering, concerned with delay systems. A relevant feature of the book is that it also provides the Matlab codes to encourage the readers to experience the practical aspects. They could use the codes to test the theory and to analyze the performances of the methods on the given examples. Moreover, they could easily modify them to tackle the numerical stability analysis of their own delay models.

Abstract semilinear functional differential equations arise from many biological, chemical, and physical systems which are characterized by both spatial and temporal variables and exhibit various spatio-temporal patterns. The aim of this book is to provide an introduction of the qualitative theory and applications of these equations from the dynamical systems point of view. The required prerequisites for that book are at a level of a graduate student. The style of presentation will be appealing to people trained and interested in qualitative theory of ordinary and functional differential equations.

Mathematics plays an important role in many scientific and engineering disciplines. This book deals with the numerical solution of differential equations, a very important branch of mathematics. Our aim is to give a practical and theoretical account of how to solve a large variety of differential equations, comprising ordinary differential equations, initial value problems and boundary value problems, differential algebraic equations, partial differential equations and delay differential equations. The solution of differential equations using R is the main focus of this book. It is therefore intended for the practitioner, the student and the scientist, who wants to know how to use R for solving differential equations. However, it has been our goal that non-mathematicians should at least understand the basics of the methods, while obtaining entrance into the relevant literature that provides more mathematical background. Therefore, each chapter that deals with R examples is preceded by a chapter where the theory behind the numerical methods being used is introduced. In the sections that deal with the use of R for solving differential equations, we have taken examples from a variety of disciplines, including biology, chemistry, physics, pharmacokinetics. Many examples are well-known test examples, used frequently in the field of numerical analysis.