Comparative studies between HTLV-1 and HTLV-2 function and pathobiology

Comparative studies between HTLV-1 and HTLV-2 function and pathobiology
Author :
Publisher : Frontiers Media SA
Total Pages : 95
Release :
ISBN-10 : 9782889194988
ISBN-13 : 2889194981
Rating : 4/5 (88 Downloads)

Synopsis Comparative studies between HTLV-1 and HTLV-2 function and pathobiology by : Umberto Bertazzoni

Human T-cell leukemia viruses type 1 and 2 (HTLV-1 and HTLV-2) share a common genetic organization, expression strategy and ability to infect and immortalize T-cells in vitro; however, HTLV-1 and HTLV-2 are strikingly different in terms of clinical impact. HTLV-1 is recognized as the aetiological agent of adult T-cell leukemia/lymphoma (ATLL), and HTLV-associated myeolopathy/tropical spastic paraparesis (HAM/TSP), in contrast, HTLV-2 does not cause hematologic disorders and is only sporadically associated with cases of subacute myelopathy. HTLV-1 and HTLV-2 also exhibit distinct cellular tropisms in vivo: HTLV-1 is mainly found in CD4+T lymphocytes, whereas CD8+T-cells are the preferred target for HTLV-2. The articles contributed in this Research Topic are covering all the different aspects that characterize HTLV-1 and HTLV-2, by highlighting differences in their biology that might provide clues to their distinct pathogenic properties.

Molecular Pathology of HTLV-1

Molecular Pathology of HTLV-1
Author :
Publisher : Frontiers Media SA
Total Pages : 225
Release :
ISBN-10 : 9782889457502
ISBN-13 : 2889457508
Rating : 4/5 (02 Downloads)

Synopsis Molecular Pathology of HTLV-1 by : Umberto Bertazzoni

Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered, in 1980, by Gallo and co-workers. About 5-10% of HTLV-1-infected individuals are at risk of developing either a fatal malignancy, adult T-cell leukemia (ATL), or a chronic neuroinflammatory syndrome, HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Both diseases are incurable at present. Many issues concerning HTLV-1’s life cycle and pathobiology are still unsolved or controversial, and new approaches for prognostic stratification of patients and eradication of HTLV-1 infection are in high demand. In this Research Topic, the focus has been centered on discussing two main themes: the functional analysis and oncogenic potential of HTLV-1 regulatory proteins and the control of HTLV-1-associated diseases. The 22 articles in this eBook cover many different aspects of HTLV-1 infection and pathogenesis, providing new perspectives and groundwork for future studies.

Viral and Immunological Malignancies

Viral and Immunological Malignancies
Author :
Publisher : PMPH-USA
Total Pages : 440
Release :
ISBN-10 : 1550092561
ISBN-13 : 9781550092561
Rating : 4/5 (61 Downloads)

Synopsis Viral and Immunological Malignancies by : Paul Volberding

The precise relationship between viral infection and malignancy remains an epidemiologic association and the subject of active investigation. Nonmalignant hematologic disorders have a similarly complex relationship with cancer-associated viruses and may offer insight into the pathogenesis of oncogenesis. This book explores the relationships between viral infections, immune impairments and the hematologic and malignant diseases, particularly against the backdrop of the HIV epidemic. By extending the scope to all of viral oncology the editors provide an invaluable resource on tumors related to other viruses other than HIV, particularly carcinomas of the cervix and anus with HPV and tumors of the liver with the various hepatitis viruses.

Human Cancer Viruses

Human Cancer Viruses
Author :
Publisher : Karger Medical and Scientific Publishers
Total Pages : 257
Release :
ISBN-10 : 9783805585767
ISBN-13 : 3805585764
Rating : 4/5 (67 Downloads)

Synopsis Human Cancer Viruses by : John Nicholas

The first identification of a tumor-causing virus, Rous sarcoma virus, occurred almost 100 years ago, but it was not until the 1970s that the genetic basis for oncogenesis by this and other acutely transforming retroviruses was appreciated. Since then, numerous viral oncogenes and their corresponding cellular proto-oncogene counterparts have been identified, and these studies have contributed much to our understanding of crucially important aspects of cell biology and transformation.This book provides an up-to-date overview of the 6 major viruses that cause human cancers - HPV, HBV, HCV, EBV, KSHV and HTLV-1 - with respect to their molecular biology and epidemiology and to clinical aspects of disease, therapy and prevention. Contributed by over a dozen internationally renowned scientists, the chapters are comprehensively written and illustrated. The book is suitable for advanced students, postdoctoral researchers, scientists and clinicians who wish to understand the mechanisms leading to cellular transformation and oncogenesis by these viruses as a basis for the development of specific therapeutic and antiviral treatments.

Molecular Mimicry: Infection Inducing Autoimmune Disease

Molecular Mimicry: Infection Inducing Autoimmune Disease
Author :
Publisher : Springer Science & Business Media
Total Pages : 166
Release :
ISBN-10 : 9783540307914
ISBN-13 : 3540307915
Rating : 4/5 (14 Downloads)

Synopsis Molecular Mimicry: Infection Inducing Autoimmune Disease by : Michael B. A. Oldstone

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Retroviral Proteases

Retroviral Proteases
Author :
Publisher : Gulf Professional Publishing
Total Pages : 494
Release :
ISBN-10 : 0121821420
ISBN-13 : 9780121821425
Rating : 4/5 (20 Downloads)

Synopsis Retroviral Proteases by : Lawrence C. Kuo

Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.

Human Retrovirology

Human Retrovirology
Author :
Publisher : Raven Press (ID)
Total Pages : 520
Release :
ISBN-10 : UOM:39015019396087
ISBN-13 :
Rating : 4/5 (87 Downloads)

Synopsis Human Retrovirology by : William A. Blattner

Dermatology in Public Health Environments

Dermatology in Public Health Environments
Author :
Publisher : Springer
Total Pages : 1581
Release :
ISBN-10 : 9783319339191
ISBN-13 : 3319339192
Rating : 4/5 (91 Downloads)

Synopsis Dermatology in Public Health Environments by : Renan Rangel Bonamigo

This book provides a reference guide in the field of dermatology, presenting and discussing its interface with public health. Dermatological diseases are extremely common in populations around the globe, and the systematization of knowledge about these dermatoses and their relationships with different epidemiological factors may help us to understand the challenges that governments and private institutions face and must try to overcome in order to improve global health. Undergraduate and graduate students, dermatologists and general practitioners who study and / or work in the area will find scientific support in this book, which is intended as a reference work for dermatological practice and public health. The book has ten sections addressing carefully selected topics, including: 1. concepts in dermatoepidemiology and the international strategies in programs of Public Health; 2-6. the most significant skin diseases (including dermatology in tropical medicine) ; 7. diseases that are not primarily dermatological, but have a high impact on public health and may have skin and mucosal manifestations; 8. a number of emerging issues in dermatology in public health; 9. clinical approaches (diagnosis and management) to common dermatological symptoms and 10. multidisciplinary approaches in dermatology. The editors have brought together authors with extensive experience in their respective fields in order to provide a reference book for those involved in or with an interest in the relationship between dermatology and public health.