Group testing has been used in medical, chemical and electrical testing, coding, drug screening, pollution control, multiaccess channel management, and recently in data verification, clone library screening and AIDS testing. The mathematical model can be either combinatorial or probabilistic. This book summarizes all important results under the combinatorial model, and demonstrates their applications in real problems. Some other search problems, including the famous counterfeit-coins problem, are also studied in depth. There are two reasons for publishing a second edition of this book. The first is the usual need to update the text (after six years) and correct errors. The second -- and more important -- reason is to accommodate the recent sudden growth of interest in applying the idea of group testing to clone library screening. This development is much more than just a new application, since the new application brings with it new objectives which require a new twist of theory. It also embraces the growing importance of two topics: nonadaptive algorithms and error tolerance. Two new chapters, one on clone library screening and the other on error tolerance, have been added. Also included is a new chapter on counterfeit coins, the most famous search problem historically, which recently drew on an unexpected connection to some deep mathematical theory to yield new results. Finally, the chapters have been recognized into parts to provide focuses and perspectives.

Du (computer science, City U. of Hong Kong) and Hwant (applied mathematics, National Chiao Tung U., Taiwan) assemble the theories and applications of a technique for testing blood on a large scale economically. They say it was developed about 50 years ago, but went dormant when the immediate need passed, and think it might be useful again now what with the AIDS epidemic and all. They mention no date for the first edition; not only have they updated results and corrected errors here, they have also incorporated the recent extensive application of non-adaptive group testing to the clone library screening problem. Annotation copyrighted by Book News, Inc., Portland, OR

Group testing has been used in medical, chemical and electrical testing, coding, drug screening, pollution control, multiaccess channel management, and recently in data verification, clone library screening and AIDS testing. The mathematical model can be either combinatorial or probabilistic. This book summarizes all important results under the combinatorial model, and demonstrates their applications in real problems. Some other search problems, including the famous counterfeit-coins problem, are also studied in depth.There are two reasons for publishing a second edition of this book. The first is the usual need to update the text (after six years) and correct errors. The second — and more important — reason is to accommodate the recent sudden growth of interest in applying the idea of group testing to clone library screening. This development is much more than just a new application, since the new application brings with it new objectives which require a new twist of theory. It also embraces the growing importance of two topics: nonadaptive algorithms and error tolerance. Two new chapters, one on clone library screening and the other on error tolerance, have been added. Also included is a new chapter on counterfeit coins, the most famous search problem historically, which recently drew on an unexpected connection to some deep mathematical theory to yield new results. Finally, the chapters have been reorganized into parts to provide focuses and perspectives.

Pooling designs have been widely used in various aspects of DNA sequencing. In biological applications, the well-studied mathematical problem called “group testing” shifts its focus to nonadaptive algorithms while the focus of traditional group testing is on sequential algorithms. Biological applications also bring forth new models not previously considered, such as the error-tolerant model, the complex model, and the inhibitor model. This book is the first attempt to collect all the significant research on pooling designs in one convenient place.The coverage includes many real biological applications such as clone library screening, contig sequencing, exon boundary finding and protein-protein interaction detecting and introduces the mathematics behind it.

From experimental design to cryptography, this comprehensive, easy-to-access reference contains literally all the facts you need on combinatorial designs. It includes constructions of designs, existence results, and properties of designs. Organized into six main parts, the CRC Handbook of Combinatorial Designs covers:

Combinatorial mathematicians and statisticians have made a wide range of contributions to the development of block designs, and this book brings together much of that work. The designs developed for a specific problem are used in a variety of different settings. Applications include controlled sampling, randomized response, validation and valuation studies, intercropping experiments, brand cross-effect designs, lotto and tournaments.The intra- and inter- block, nonparametric and covariance analysis are discussed for general block designs, and the concepts of connectedness, orthogonality, and all types of balances in designs are carefully summarized. Readers are also introduced to the designs currently playing a prominent role in the field: alpha designs, trend-free designs, balanced treatment-control designs, nearest neighbor designs, and nested designs.This book provides the important background results required by researchers in block designs and related areas and prepares them for more complex research on the subject.

Combinatorial testing of software analyzes interactions among variables using a very small number of tests. This advanced approach has demonstrated success in providing strong, low-cost testing in real-world situations. Introduction to Combinatorial Testing presents a complete self-contained tutorial on advanced combinatorial testing methods for re

This volume is dedicated to the memory of Rudolf Ahlswede, who passed away in December 2010. The Festschrift contains 36 thoroughly refereed research papers from a memorial symposium, which took place in July 2011. The four macro-topics of this workshop: theory of games and strategic planning; combinatorial group testing and database mining; computational biology and string matching; information coding and spreading and patrolling on networks; provide a comprehensive picture of the vision Rudolf Ahlswede put forward of a broad and systematic theory of search.

This volume presents selected papers from a three-day workshop held during the DIMACS special years on Mathematical Support for Molecular Biology. Participants from the world over attended, giving the workshop an important international component. The study of discrete mathematics and optimization with medical applications is emerging as an important new research area. Significant applications have been found in medical research, for example in radiosurgical treatment planning, virtual endoscopy, and more. This volume presents a substantive cross-section of active research topics ranging from medical imaging to human anatomy modelling, from gamma knife treatment planning to radiation therapy, and from epileptic seizures to DNA screening. This book is an up-to-date resource reflecting current research directions.

The papers in this volume were presented at the Eleventh Annual International Computing and Combinatorics Conference (COCOON 2005), held August 16–19, 2005, in Kunming, China.