A history of the art of transfusions and a scientific discourse on the chemistry of blood.

Centred on the relationship between the personal lives of the writers John Middleton Murry, Katherine Mansfield, and D. H. Lawrence and the works they produced this intriguing study develops a portrait of a circle of writers who significantly influenced t

This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

The microcirculation of the gastrointestinal tract is under the control of both myogenic and metabolic regulatory systems. The myogenic mechanism contributes to basal vascular tone and the regulation of transmural pressure, while the metabolic mechanism is responsible for maintaining an appropriate balance between O2 demand and O2 delivery. In the postprandial state, hydrolytic products of food digestion elicit a hyperemia, which serves to meet the increased O2 demand of nutrient assimilation. Metabolically linked factors (e.g., tissue pO2, adenosine) are primarily responsible for this functional hyperemia. The fenestrated capillaries of the gastrointestinal mucosa are relatively permeable to small hydrolytic products of food digestion (e.g., glucose), yet restrict the transcapillary movement of larger molecules (e.g., albumin). This allows for the absorption of hydrolytic products of food digestion without compromising the oncotic pressure gradient governing transcapillary fluid movement and edema formation. The gastrointestinal microcirculation is also an important component of the mucosal defense system whose function is to prevent (and rapidly repair) inadvertent epithelial injury by potentially noxious constituents of chyme. Two pathological conditions in which the gastrointestinal circulation plays an important role are ischemia/reperfusion and chronic portal hypertension. Ischemia/reperfusion results in mucosal edema and disruption of the epithelium due, in part, to an inflammatory response (e.g., increase in capillary permeability to macromolecules and neutrophil infiltration). Chronic portal hypertension results in an increase in gastrointestinal blood flow due to an imbalance in vasodilator and vasoconstrictor influences on the microcirculation. Table of Contents: Introduction / Anatomy / Regulation of Vascular Tone and Oxygenation / Extrinsic Vasoregulation: Neural and Humoral / Postprandial Hyperemia / Transcapillary Solute Exchange / Transcapillary Fluid Exchange / Interaction of Capillary and Interstitial Forces / Gastrointestinal Circulation and Mucosal Defense / Gastrointestinal Circulation and Mucosal Pathology I: Ischemia/Reperfusion / Gastrointestinal Circulation and Mucosal Pathology II: Chronic Portal Hypertension / Summary and Conclusions / References / Author Biography

A new history of the queer novel shows its role in constructing gay and lesbian lives The gay and lesbian novel has long been a distinct literary genre with its own awards, shelving categories, bookstore spaces, and book reviews. But very little has been said about the remarkable history of its emergence in American literature, particularly the ways in which the novel about homosexuality did not just reflect but actively produced queer life. Drawing on Mikhail Bakhtin’s insight that the history of society is connected to the history of language, author Natasha Hurley charts the messy, complex movement by which the queer novel produced the very frames that made it legible as a distinct literature and central to the imagination of queer worlds. Her vision of the queer novel's development revolves around the bold argument that literary circulation is the key ingredient that has made the gay and lesbian novel and its queer forebears available to its audiences. Challenging the narrative that the gay and lesbian novel came into view in response to the emergence of homosexuality as a concept, Hurley posits a much longer history of this novelistic genre. In so doing, she revises our understanding of the history of sexuality, as well as of the processes of producing new concepts and the evolution of new categories of language.

Transmitting and Circulating the Late Antique and Byzantine Worlds seeks to be a crucial contribution to the history of medieval connectedness. Using one of the methodological tools associated with the global history movement, this volume aims to use connectedness to revitalise local and regional networks of exchange and movement. Its case studies collectively point caution toward assuming or asserting global-scale transmission of meaning or items unchanged, and show instead how meaning is locally produced and regionally formulated, and how this is no less dynamic than any global-level connectedness. These case studies by early career scholars range from the movement of cotton growing practices to the transmission of information within individual texts. Their wide scope, however, is nonetheless united by their preoccupation with transmission and circulation as categories of analysing or explaining movement and change in history. This volume hopes to be, therefore, a useful contribution to the growing field of a history of connectivity and connectedness. Contributors are Jovana Anđelković, Petér Bara, Mathew Barber, Julia Burdajewicz, Adele Curness, Carl Dixon, Alex MacFarlane, Anna Kelley, Matteo G. Randazzo, Katinka Sewing and Grace Stafford. See inside the book.