For a food product to be a success in the marketplace it must be stable throughout its shelf-life. Quality deterioration due to chemical changes and alterations in condition due to physical instability are not always recognised, yet can be just as problematic as microbial spoilage. This book provides an authoritative review of key topics in this area. Chapters in part one focus on the chemical reactions which can negatively affect food quality, such as oxidative rancidity, and their measurement. Part two reviews quality deterioration associated with physical changes, such as moisture loss, gain and migration, crystallization and emulsion breakdown. Contributions in the following section outline the likely effects on different foods and beverages, including bakery products, fruit and vegetables, ready-to-eat meals and wine. With contributions from leaders in their fields, Chemical deterioration and physical instability of food and beverages is an essential reference for R&D and QA staff in the food industry and researchers with an interested in this subject. - Examines chemical reactions which can negatively affect food quality and measurement - Reviews quality deterioration associated with physical changes such as moisture loss, gain and migration, and crystallization - Documents deterioration in specific food and beverage products including bakery products, frozen foods and wine

On March 14-18, 1983 a workshop on "Chemical Instabilities: Applications in Chemistry, Engineering, Geology, and Materials Science" was held in Austin, Texas, U.S.A. It was organized jointly by the University of Texas at Austin and the Universite Libre de Bruxelles and sponsored qy NATO, NSF, the University of Texas at Austin, the International Solvay Institutes and the Ex xon Corporation. The present Volume includes most of the material of the in vited lectures delivered in the workshop as well as material from some posters, whose content was directly related to the themes of the invited lectures. In ,recent years, problems related to the stability and the nonlinear dynamics of nonequilibrium systems invaded a great num ber of fields ranging from abstract mathematics to biology. One of the most striking aspects of this development is that subjects reputed to be "classical" and "well-established" like chemistry, turned out to give rise to a rich variety of phenomena leading to multiple steady states and hysteresis, oscillatory behavior in time, spatial patterns, or propagating wave fronts. The primary objective of the workshop was to bring together researchers actively engaged in fields in which instabilities and nonlinear phenomena similar to those observed in chemistry are of current and primary concern : chemical engineering (especially surface catalysis), combustion (dynamics of ignition, flame sta bili t;y), interfaces (emulsification, dendritic growth), geology (regularly repeated patterns of mineralization 1n a variety of spabe scales), and materials science (dynamical solidification, behavior of matter under irradiation).

Provides a sound theoretical basis for understanding chemical kinetics and its uses in studying drug stability. Treats the calculations, approximations, and estimates that are useful to the pharmacist in professional practice, and presents a collection of selected drug-stability data from the pharmaceutical literature. This Handbook makes accessible to the pharmacist much of the information necessary to make pharmaceutical decisions about drug stability. Changes in this edition include thorough revision of the chapter on oxidation, addition of a new chapter on solid-state stability, and a tripling of the number of stability monographs. All monographs figures have been redrawn, most of them from published data, and all sources are cited.

Scientists in many fields are now expressing considerable interest in non-linearity and the ideas of oscillations and chaos. Chemical reactions provide perfect examples of these phenomena, as oscillating reactions, explosions, ignition, travelling waves, patterns, quasiperiodicity, and chaosare all features of chemical kinetics.Now available in paperback, this book introduces non-linear phenomena in chemical kinetics using simple model schemes. These models involve chemical feedback, such as chain branching, autocatalysis, and self-heating. The emphasis is on physical and pictorial representation, and on identifying thosegross features which are essential. The experimental conditions under which such behaviour will occur can be predicted using simple mathematical recipes, and these are also included.The first part of the book begins with a discussion of long-lived oscillations for autocatalytic or exothermic reactions in closed vessels. Stationary states, bistability, and oscillations in continuous flow reactors and diffusion cells are then considered. This is followed by chemical wavepropagation and by pattern selection and oscillations. Complex oscillations, quasiperiodicity, and chemical chaos, either forced or spontaneous, are introduced. Part 2 deals with real experimental systems, describing observed experimental behaviour and its interpretation in terms of the underlyingchemical mechanisms or simplified models. The Belousov-Zhabotinskii reactions is discussed in some detail as the most extensively studied system, and the behaviour of important gas phase reactions is presented.

Drug Stability for Pharmaceutical Scientists is a clear and easy-to-follow guide on drug degradation in pharmaceutical formulation. This book features valuable content on both aqueous and solid drug solutions, the stability of proteins and peptides, acid-base catalyzed and solvent catalyzed reactions, how drug formulation can influence drug stability, the influence of external factors on reaction rates and much more. Full of examples of real-life formulation problems and step-by-step calculations, this book is the ideal resource for graduate students, as well as scientists in the pharmaceutical and related industries. - Illustrates important theoretical concepts with numerous examples, figures, calculations, learning problems and questions for self-study and retention of material - Provides answers and explanations to test your knowledge - Enables you to better understand key concepts such as rate and order of reaction, reaction equilibrium, complex reaction mechanisms and more - Includes an in-depth discussion of both aqueous and solid drug solutions and contains the latest international regulatory requirements on drug stability

An important resource that puts the focus on understanding and handling of organic crystals in drug development Since a majority of pharmaceutical solid-state materials are organic crystals, their handling and processing are critical aspects of drug development. Pharmaceutical Crystals: Science and Engineering offers an introduction to and thorough coverage of organic crystals, and explores the essential role they play in drug development and manufacturing. Written contributions from leading researchers and practitioners in the field, this vital resource provides the fundamental knowledge and explains the connection between pharmaceutically relevant properties and the structure of a crystal. Comprehensive in scope, the text covers a range of topics including: crystallization, molecular interactions, polymorphism, analytical methods, processing, and chemical stability. The authors clearly show how to find solutions for pharmaceutical form selection and crystallization processes. Designed to be an accessible guide, this book represents a valuable resource for improving the drug development process of small drug molecules. This important text: Includes the most important aspects of solid-state organic chemistry and its role in drug development Offers solutions for pharmaceutical form selection and crystallization processes Contains a balance between the scientific fundamental and pharmaceutical applications Presents coverage of crystallography, molecular interactions, polymorphism, analytical methods, processing, and chemical stability Written for both practicing pharmaceutical scientists, engineers, and senior undergraduate and graduate students studying pharmaceutical solid-state materials, Pharmaceutical Crystals: Science and Engineering is a reference and textbook for understanding, producing, analyzing, and designing organic crystals which is an imperative skill to master for anyone working in the field.

In recent years many research workers have turned their attention to the quantitative characterization of complex compounds and reactions of complex-formation in solution. Instability constants characterize quantitatively the equili bria in solutions of complex compounds and are extensively used by chemists of widely-varying specialities, in analytical chemistry, electrochemistry, the technology of non-ferrous and rare metals, etc., for calculations of various kinds. Despite the wealth of numerical data, no reasonably full coliection of instability constants of complex compounds has been made until now. The various individual collections of data are far from complete and in most cases omit references to the source materials. Moreover, the present state of the chemistry of complex compounds most urgently demands the complete systematization of data on instability constants and an extension of work in this field which would take advantage of the latest physico-chemical methods. The present work contains instability constants for 1,381 complex compounds. We have considered it convenient to preface the summary of the instability constants with an introductory section of a general theoretical character. This section deals with methods for the calculation of instability constants from experimental data, the influence of external conditions, such as temperature and ionic strength, on the stability of com plexes, and the principal factors determining the stability of complex compounds in aqueous solution. (vii) PREFACE In compiling the summary we have used the original litera ture and abstracts for the most part up to 1954, and some work published in 1955-1956.

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. - Serves as an essential working handbook aimed at scientists and students in medicinal chemistry - Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies - Discusses improvements in pharmacokinetics from a practical chemist's standpoint

Food Shelf Life Stability provides a unique approach to understanding this critical subject by examining physical, chemical, and biochemical factors affecting food quality. The first section emphasizes the effects that water activity, glass transition, and plasticization have on temperature, water content, and time-dependant phenomena affecting

When caring for patients, medication stability should be the least of your worries. Extended Stability for Parenteral Drugs, Fifth Edition, is the indispensable go-to reference for anyone working in alternate site infusion or preparing sterile compounds. This new edition will help you safely extend beyond-use dating of parenteral medications to minimize waste and reduce costs. What''s New in This Edition? � 160 updated monographs, including 10 new to this edition: o Acetaminophen o Ceftaroline fosamil o Coagulation Factor XIII o Doripenem o Ethanol lock o Ibuprofen o Pantoprazole o Telavancin o Toclizumab o Ziconotide acetate � 24 parenteral nutrition monographs include additional considerations for calcium and phosphate solubility. � Monograph updates include revisions to several container types and new information for elastometric infusion device brands. The Applying Stability Data in Patient Care section now includes a nursing perspective, a primer on the types of vascular access devices used in medication administration, and important considerations for pH, osmolality, concentration, and administration devices. With expanded tables and enhanced references, Extended Stability for Parenteral Drugs, Fifth Edition, is the only publication that brings key stability data on the most commonly used IV solutions, medications, and administration devices, together in one convenient, easy-to-use guide.