Cancer Crossings -- Foreword -- 1 -- 2 -- 3 -- 4 -- 5 -- 6 -- 7 -- 8 -- 9 -- 10 -- 11 -- 12 -- 13 -- 14 -- 15 -- 16 -- 17 -- 18 -- 19 -- 20 -- 21 -- 22 -- 23 -- 24 -- 25 -- 26 -- 27 -- 28 -- 29 -- 30 -- 31 -- 32 -- 33 -- 34 -- 35 -- 36 -- 37 -- 38 -- Acknowledgments -- Notes -- Further Readings

When Eric Wendel was diagnosed with acute lymphoblastic leukemia in 1966, the survival rate was 10 percent. Today, it is 90 percent. Even as politicians call for a "Cancer Moonshot," this accomplishment remains a pinnacle in cancer research. The author’s daughter, then a medical student at Georgetown Medical School, told her father about this amazing success story. Tim Wendel soon discovered that many of the doctors at the forefront of this effort cared for his brother at Roswell Park in Buffalo, New York. Wendel went in search of this extraordinary group, interviewing Lucius Sinks, James Holland, Donald Pinkel, and others in the field. If there were a Mount Rushmore for cancer research, they would be on it. Despite being ostracized by their medical peers, these doctors developed modern-day chemotherapy practices and invented the blood centrifuge machine, helping thousands of children live longer lives. Part family memoir and part medical narrative, Cancer Crossings explores how the Wendel family found the courage to move ahead with their lives. They learned to sail on Lake Ontario, cruising across miles of open water together, even as the campaign against cancer changed their lives forever.

Crossings is a collection of short stories that began years ago with scribblings on Post-it notes and journals, all set aside while the author was engulfed in a teaching career, a poetry group with university colleagues and writing for the academic marketplace. Resurfaced, completed and revised, the stories grew out of her favorite words: what if, words that plunged her into a world of the paranormal and all manner of phenomenon that, but for the courage of a cadre of researchers and experiencers, often rest outside the realm of science and too often the object of ridicule and indifference. Beginning with, “The Crossing,” Boston is home to the characters in each tale, a city with a long and varied history of American experience. The first-person “telling” by the central characters intimately connects each narrator with the reader in these tales of the unexpected and unexplained, a journey behind the curtain where curiosity and experience lay.

Crossing Over provides a unique view of patients, families, and their caregivers in the face of incurable illness. Twenty richly-detailed narratives bring vividly to life the experiences of dying and bereavement, weaving together emotions, physical symptoms, spiritual concerns, and the stresses of family life, as well as the professional and personal challenges of providing hospice and palliative care. Drawing on a variety of qualitative research methods, including participant-observation, interviews, and journal keeping, the narratives depict the sights, sounds, tastes, and smells of daily life in patients' homes and in the palliative care unit. Crossing Over moves far beyond conventional case reports in medicine, which typically concentrate narrowly on symptoms and treatments, and beyond clichés about "dying with dignity." It provides intimate views of the anger and fear, tenderness and reconciliation, jealousy and love, unexpected courage and unshakable faith, social support and "falling through the cracks," which are all part of facing death in North American society. It provides an extraordinary portrait of the processes of giving and receiving hospice and palliative care in the real world, as opposed to idealized versions in many textbooks. This edition of Crossing Over has been thoroughly revised and updated to reflect changes in hospice and palliative care and in North American society since the first edition in 2000. Chief among these are the expansion of hospice and palliative care as a field, the ravages of the COVID-19 pandemic, the wider availability of medical aid in dying, and a heightened awareness of how structural racism, classism, and other forms of discrimination shape individuals' and families' experiences right up to the close of life.

From the award-winning author of Crossing Ocean Parkway, a personal memoir about adjusting to loss through books, meditation, and the process of memory itself Marianna De Marco Torgovnick experienced the rupture of two of her life’s most intimate relations when her mother and brother died in close proximity. Mourning rocked her life, but it also led to the solace and insight offered by classic books and the practice of meditation. Her resulting journey into the past imagines a viable future and raises questions acute for Italian Americans but pertinent to everyone, about the nature of memory and the meanings of home at a time, like ours, marked by cultural disruption and wartime. Crossing Back: Books, Family, and Memory without Pain presents a personal perspective on death, mourning, loss, and renewal. A sequel to her award-winning and much-anthologized Crossing Ocean Parkway, Crossing Back is about close familial ties and personal loss, written after the death of her remaining birth family, who had always been there, and now were not. After their loss, she entered a spiritual and psychological state of “transcendental homelessness”: the feeling of being truly at home nowhere, of being spiritually adrift. In a grand act of symbolic reenactment, she found herself moving apartments repeatedly, not realizing she did so subconsciously to keep busy, to stave off grief. By reading and studying great books, she opened up to mourning, a process she constitutionally resisted as somehow shameful. Over time, she discovered that a third death colored and prolonged her feelings of grief: her first child’s death in infancy, which, in the course of a happier lifetime, had never been adequately acknowledged. Her new losses led her finally to take stock of her son’s death too. Reading and meditating, followed by writing, became daily her healing rituals. A warm and intimate user’s guide to books, family, and memory in the mourning process, the end-point being memory without pain, Crossing Back is a wide-ranging memoir about growing older and learning to ride the waves of change. Lively and conversational, Torgovnick is masterful at tracking the moment-to moment, day-to-day challenges of sudden or protracted grief and the ways in which the mind and the body seem to search for—and sometimes find—solutions.

A close look at Günter Blobel’s transformative contributions to molecular cell biology. The difficulty of reconciling chemical mechanisms with the functions of whole living systems has plagued biologists since the development of cell theory in the nineteenth century. As Karl S. Matlin argues in Crossing the Boundaries of Life, it is no coincidence that this longstanding knot of scientific inquiry was loosened most meaningfully by the work of a cell biologist, the Nobel laureate Günter Blobel. In 1975, using an experimental setup that did not contain any cells at all, Blobel was able to target newly made proteins to cell membrane vesicles, enabling him to theorize how proteins in the cell distribute spatially, an idea he called the signal hypothesis. Over the next twenty years, Blobel and other scientists were able to dissect this mechanism into its precise molecular details. For elaborating his signal concept into a process he termed membrane topogenesis—the idea that each protein in the cell is synthesized with an "address" that directs the protein to its correct destination within the cell—Blobel was awarded the Nobel Prize in Physiology or Medicine in 1999. Matlin argues that Blobel’s investigative strategy and its subsequent application addressed a fundamental unresolved dilemma that had bedeviled biology from its very beginning—the relationship between structure and function—allowing biology to achieve mechanistic molecular explanations of biological phenomena. Crossing the Boundaries of Life thus uses Blobel’s research and life story to shed light on the importance of cell biology for twentieth-century science, illustrating how it propelled the development of adjacent disciplines like biochemistry and molecular biology.

Second in a series of publications from the Institute of Medicine's Quality of Health Care in America project Today's health care providers have more research findings and more technology available to them than ever before. Yet recent reports have raised serious doubts about the quality of health care in America. Crossing the Quality Chasm makes an urgent call for fundamental change to close the quality gap. This book recommends a sweeping redesign of the American health care system and provides overarching principles for specific direction for policymakers, health care leaders, clinicians, regulators, purchasers, and others. In this comprehensive volume the committee offers: A set of performance expectations for the 21st century health care system. A set of 10 new rules to guide patient-clinician relationships. A suggested organizing framework to better align the incentives inherent in payment and accountability with improvements in quality. Key steps to promote evidence-based practice and strengthen clinical information systems. Analyzing health care organizations as complex systems, Crossing the Quality Chasm also documents the causes of the quality gap, identifies current practices that impede quality care, and explores how systems approaches can be used to implement change.

In 2015, building on the advances of the Millennium Development Goals, the United Nations adopted Sustainable Development Goals that include an explicit commitment to achieve universal health coverage by 2030. However, enormous gaps remain between what is achievable in human health and where global health stands today, and progress has been both incomplete and unevenly distributed. In order to meet this goal, a deliberate and comprehensive effort is needed to improve the quality of health care services globally. Crossing the Global Quality Chasm: Improving Health Care Worldwide focuses on one particular shortfall in health care affecting global populations: defects in the quality of care. This study reviews the available evidence on the quality of care worldwide and makes recommendations to improve health care quality globally while expanding access to preventive and therapeutic services, with a focus in low-resource areas. Crossing the Global Quality Chasm emphasizes the organization and delivery of safe and effective care at the patient/provider interface. This study explores issues of access to services and commodities, effectiveness, safety, efficiency, and equity. Focusing on front line service delivery that can directly impact health outcomes for individuals and populations, this book will be an essential guide for key stakeholders, governments, donors, health systems, and others involved in health care.

In 2004, Elizabeth VanSickle was diagnosed with metastatic breast cancer. She was determined to overcome her affliction by helping others...one sock monkey at a time. Her caring spirit has enabled her to develop a unique ministry, Sock Monkey Ministries, Inc. that helps others in need by giving them a hand made sock monkey. This ministry spreads an encouraging act to let others know they are not alone in their fight. To date, over 9500 sock monkeys have been made and given to those in need of encouragement.

Making Friends with Death - A True Story Are you terrified of DEATH? Are you or a loved one facing terminal illness? Or perhaps you've already lost someone--and whether it was a long time in coming or a complete shock, it hurts. We will all meet Death at our appointed time, and when that happens, we may see him as a fearful monster. But if we get to know him first, we'll know how to handle his arrival. We may even discover that Death is not the fiend we imagined at all. Crossing the Caring Bridge offers a whole new perspective on Mr. Reaper that may prove to be a life-changing--or rather a DEATH-changing--experience! "I've seen death come. I've seen people who've lost everything to hurricanes. While I've also seen close friends confront cancer and death, I've never been there. I can only imagine the cancer fight as a whitewater rafting trip on the fiercest rapids--but without a raft (never mind the paddles!). If I'm ever in that river, I'll want a guide. Not just any guide. This guide. Jan Briddell Stevens has been there, seen it, felt it, wept over it, and more. Her engaging storytelling style entertains, informs, and challenges. But most importantly, because she is so authentic, it comforts. Nobody needs to navigate their rivers alone." --John Chickering, Storm Recovery Team Leader, UMCOR Early Response Team (Katrina, Irene, Sandy, Irma, Maria)