"Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer."

The Nuclear Envelope brings together the major current topics in nuclear envelope structure, transport, transcriptional regulation and cell signaling. The volume is divided into four sections: 1. Proteins of the nuclear envelope, including nuclear envelope proteomics, structure and function. 2. Nuclear pores and transport at the nuclear envelope, including pore complex structure, assembly and function and import and export pathways. 3. Nuclear envelope dynamics, including dynamics of lamina assembly and disassembly. 4. Nuclear signaling and transcription regulation, including signaling to the nucleus and spectrin repeat proteins and their implications or communication between the nucleus and cytoplasm.

Advances in Nuclear Envelope Research and Application / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Nuclear Envelope in a concise format. The editors have built Advances in Nuclear Envelope Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nuclear Envelope in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Nuclear Envelope Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

The Molecular Biology of Cancer discusses the state of progress in the molecular biology of cancer. The book describes the effects of anticancer agents on nucleolar ultrastructure; the role of chromosomes in the causation and progression of cancer and leukemia; the replication, modification, and repair of DNA. The text also describes the metabolism and utilization of messenger RNA and other high molecular weight RNA and low molecular weight nuclear RNA; the characteristics, structures, and functions of nuclear proteins; and the process of protein synthesis. Nucleotides are reviewed with regard ...

. What is cancer?, L.M. Franks and Margaret A. Knowles. 2. The causes of cancer, Naomi Allen, Robert Newton, Amy Berrington de Gonzalez, Jane Green, Emily Banks, and Timothy J. Key. 3. Inherited Susceptibility to Cancer, D. Timothy Bishop. 4. DNA Repair and Cancer, Beate Koberle, John P. Wittschieben, and Richard D. Wood. 5. Epigenetic Events in Cancer, Jonathan C. Cheng and Peter A. Jones. 6. Molecular Cytogenetics of Cancer, Denise. Sheer and Janet Shipley. 7. Oncogenes, Margaret A. Knowles. 8. Tumour suppressor genes, Sonia Lain and David P. Lane. 9. The cancer cell cycle, Chris J. Norbury. 10. Cellular immortalization and telomerase activation in cancer, Robert F. Newbold. 11. Growth factors and their signalling pathways in cancer, Sally A. Prigent. 12. Apoptosis: molecular physiology and significance for cancer therapeutics, Dean A. Fennell. 13. Mechanisms of Viral Carcinogenesis, Paul Farrell. 14. Cytokines and Cancer, Peter W. Szlosarek and Frances R. Balkwill. 15. Hormones and cancer, Charlotte L. Bevan. 16. The spread of tumours, Ian Hart. 17. Angiogenesis, K.Tahtis and R.Bicknell. 18. Stem cells, heamopoiesis, and leukaemia, Mel Greaves. 19. Animal models of cancer, Jos Jonkers and Anton Berns. 20. The immunology of cancer, Peter C. L. Beverley. 21. The molecular pathology of cancer, Tatjana Crnogorac-Jurcevic, Richard Poulsom, and Nicholas R. Lemoine. 22. From transcriptome to proteome, Silvana Debernardi, Rachel Craven, Bryan D. Young, and Rosamonde E. Banks. 23. Local treatment of cancer, Ian S. Fentiman. 24. Chemotherapy, D.R. Camidge and D.I. Jodrell. 25. Radiotherapy and molecular radiotherapy, Anne Kiltie. 26. Monoclonal antibodies and therapy, T. Geldart, M.J. Glennie, and P.W.M. Johnson. 27. Immunotherapy of cancer, Andrew M. Jackson and Joanne Porte. 28. Cancer gene therapy, John David Chester. 29. Screening, Peter Sasieni and Jack Cuzick. 30. Conclusions and prospects, Peter Selby and Margaret A Knowles.

Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.

Cancer is a multifaceted disease and overwhelmingly increasing experimental evidence has helped us to develop a deeper understanding of the role of signal transduction cascades in cancer development and progression. Tissue microarrays and next generation sequencing technologies have assisted us to gather missing pieces of jigsaw puzzle and we now know that deregulation of spatio-temporally controlled signaling cascades play fundamental role in metastasis and resistance against wide ranging therapeutics. This book offers a balanced overview of the rapidly emerging cutting edge research in molecular oncology and good source of knowledge for established oncologists, basic and medical students and pharmaceutical industry associated R&D departments.

The nucleus, defined by its enclosing boundary, the nuclear envelope, is the largest organelle in most eukaryotic cells and houses the nuclear genome. It has been implicated in various physiological processes crucial to normal cell function, processes that are often altered in disease. Here we show that the re-establishment of this critical organelle after cellular division is achieved by a co-opting of numerous proteins of the inner nuclear membrane that interact with DNA/chromatin and that each serve distinct interphase functions. That such a large number of proteins and resources are dedicated to the rapid reformation of the nuclear envelope and proper nuclear compartmentalization suggests its critical importance for normal cell function. Subsequently, we show that this barrier function and the integrity of the nuclear envelope is transiently disrupted in human cancer cells, leading to the mislocalization of both nuclear and cytoplasmic proteins. In extreme cases, this loss of integrity leads to a partial loss of cellular compartmentalization, with normally cytoplasmic organelles appearing in the interior of the cell nucleus. These rupture events are transient and recoverable, but the efflux of genomic material from the nucleus during such events suggests potential genomic insult that may contribute to alterations in genetic information and to the transformation process in cancer.