C H Activation For Asymmetric Synthesis
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Author |
: Françoise Colobert |
Publisher |
: John Wiley & Sons |
Total Pages |
: 356 |
Release |
: 2019-08-29 |
ISBN-10 |
: 9783527810864 |
ISBN-13 |
: 3527810862 |
Rating |
: 4/5 (64 Downloads) |
Synopsis C-H Activation for Asymmetric Synthesis by : Françoise Colobert
Provides, in one handbook, comprehensive coverage of one of the hottest topics in stereoselective chemistry Written by leading international authors in the field, this book introduces readers to C-H activation in asymmetric synthesis along with all of its facets. It presents stereoselective C-H functionalization with a broad coverage, from outer-sphere to inner-sphere C-H bond activation, and from the control of olefin geometry to the induction of point, planar and axial chirality. Moreover, methods wherein asymmetry is introduced either during the C-H activation or in a different elementary step are discussed. Presented in two parts?asymmetric activation of C(sp3)-H bonds and stereoselective synthesis implying activation of C(sp2)-H bonds?CH-Activation for Asymmetric Synthesis showcases the diversity of stereogenic elements, which can now be constructed by C-H activation methods. Chapters in Part 1 cover: C(sp3)-H bond insertion by metal carbenoids and nitrenoids; stereoselective C-C bond and C-N bond forming reactions through C(sp3)?H bond insertion of metal nitrenoids; enantioselective intra- and intermolecular couplings; and more. Part 2 looks at: C-H activation involved in stereodiscriminant step; planar chirality; diastereoselective formation of alkenes through C(sp2)?H bond activation; amongst other methods. -Covers one of the most rapidly developing fields in organic synthesis and catalysis -Clearly structured in two parts (activation of sp3- and activation of sp2-H bonds) -Edited by two leading experts in C-H activation in asymmetric synthesis CH-Activation for Asymmetric Synthesis will be of high interest to chemists in academia, as well as those in the pharmaceutical and agrochemical industry.
Author |
: Shu-Li You |
Publisher |
: Royal Society of Chemistry |
Total Pages |
: 433 |
Release |
: 2015-08-13 |
ISBN-10 |
: 9781782621027 |
ISBN-13 |
: 1782621024 |
Rating |
: 4/5 (27 Downloads) |
Synopsis Asymmetric Functionalization of C-H Bonds by : Shu-Li You
Asymmetric C-H direct functionalization reactions are one of the most active and fascinating areas of research in organic chemistry due to their significance in the construction of molecular complexity without pre-activation, and the step economy and atom economy features in potential synthetic application. Distinguishing the reactivity among numerous C–H bonds in one single molecule represents one of the most challenging issues in organic synthesis and requires precise reaction design. As such, this field is now receiving increasing attention from researchers. This book provides the first comprehensive review of this field, summarizing the origin, mechanism, scope and applications of the asymmetric C-H bond functionalization reaction. It covers organocatalytic reactions and transition-metal-catalyzed reactions, as well as asymmetric C-H functionalization reactions not described in other books. Written by a leading expert in this field, the book is ideal for postgraduates and researchers working in organic synthesis, catalysis, and organometallic chemistry.
Author |
: Takahiko Akiyama |
Publisher |
: John Wiley & Sons |
Total Pages |
: 798 |
Release |
: 2022-06-15 |
ISBN-10 |
: 9781119736394 |
ISBN-13 |
: 1119736390 |
Rating |
: 4/5 (94 Downloads) |
Synopsis Catalytic Asymmetric Synthesis by : Takahiko Akiyama
Catalytic Asymmetric Synthesis Seminal text presenting detailed accounts of the most important catalytic asymmetric reactions known today This book covers the preparation of enantiomerically pure or enriched chemical compounds by use of chiral catalyst molecules. While reviewing the most important catalytic methods for asymmetric organic synthesis, this book highlights the most important and recent developments in catalytic asymmetric synthesis. Edited by two well-qualified experts, sample topics covered in the work include: Metal catalysis, organocatalysis, photoredox catalysis, enzyme catalysis C–H bond functionalization reactions Carbon–carbon bond formation reactions, carbon–halogen bond formation reactions, hydrogenations, polymerizations, flow reactions Axially chiral compounds Retaining the best of its predecessors but now thoroughly up to date with the important and recent developments in catalytic asymmetric synthesis, the 4th edition of Catalytic Asymmetric Synthesis serves as an excellent desktop reference and text for researchers and students, from upper-level undergraduates all the way to experienced professionals in industry or academia.
Author |
: Koichi Mikami |
Publisher |
: John Wiley & Sons |
Total Pages |
: 436 |
Release |
: 2007-05-04 |
ISBN-10 |
: 9780471680260 |
ISBN-13 |
: 0471680265 |
Rating |
: 4/5 (60 Downloads) |
Synopsis New Frontiers in Asymmetric Catalysis by : Koichi Mikami
A compilation of recent advances and applications in asymmetric catalysis The field of asymmetric catalysis has grown rapidly and plays a key role in drug discovery and pharmaceuticals. New Frontiers in Asymmetric Catalysis gives readers a fundamental understanding of the concepts and applications of asymmetric catalysis reactions and discusses the latest developments and findings. With contributions from preeminent scientists in their respective fields, it covers: * "Rational" ligand design, which is critically dependent on the reaction type (reduction, oxidation, and C-C bond formation) * Recent findings on activation of C-H bonds, C-C bonds, and small molecules (C=O, HCN, RN=C, and CO2) and the latest developments on C-C bond reorganization, such as metathesis * Advances in "chirally economical" non-linear phenomena, racemic catalysis, and autocatalysis * Some of the recent discoveries that have led to a renaissance in the field of organocatalysis, including the development of chiral Brönstead acids and Lewis acidic metals bearing the conjugate base of the Brönstead acids as the ligands and the chiral bi-functional acid/base catalysts The book ends with a thought-provoking perspective on the future of asymmetric catalysis that addresses both the challenges and the unlimited potential in this burgeoning field. This is an authoritative, up-to-date reference for organic chemists in academia, government, and industries, including pharmaceuticals, biotech, fine chemicals, polymers, and agriculture. It is also an excellent textbook for graduate students studying advanced organic chemistry or chemical synthesis.
Author |
: Françoise Colobert |
Publisher |
: John Wiley & Sons |
Total Pages |
: 240 |
Release |
: 2019-08-29 |
ISBN-10 |
: 9783527810840 |
ISBN-13 |
: 3527810846 |
Rating |
: 4/5 (40 Downloads) |
Synopsis C-H Activation for Asymmetric Synthesis by : Françoise Colobert
Provides, in one handbook, comprehensive coverage of one of the hottest topics in stereoselective chemistry Written by leading international authors in the field, this book introduces readers to C-H activation in asymmetric synthesis along with all of its facets. It presents stereoselective C-H functionalization with a broad coverage, from outer-sphere to inner-sphere C-H bond activation, and from the control of olefin geometry to the induction of point, planar and axial chirality. Moreover, methods wherein asymmetry is introduced either during the C-H activation or in a different elementary step are discussed. Presented in two parts?asymmetric activation of C(sp3)-H bonds and stereoselective synthesis implying activation of C(sp2)-H bonds?CH-Activation for Asymmetric Synthesis showcases the diversity of stereogenic elements, which can now be constructed by C-H activation methods. Chapters in Part 1 cover: C(sp3)-H bond insertion by metal carbenoids and nitrenoids; stereoselective C-C bond and C-N bond forming reactions through C(sp3)?H bond insertion of metal nitrenoids; enantioselective intra- and intermolecular couplings; and more. Part 2 looks at: C-H activation involved in stereodiscriminant step; planar chirality; diastereoselective formation of alkenes through C(sp2)?H bond activation; amongst other methods. -Covers one of the most rapidly developing fields in organic synthesis and catalysis -Clearly structured in two parts (activation of sp3- and activation of sp2-H bonds) -Edited by two leading experts in C-H activation in asymmetric synthesis CH-Activation for Asymmetric Synthesis will be of high interest to chemists in academia, as well as those in the pharmaceutical and agrochemical industry.
Author |
: Nathan Christopher Thacker |
Publisher |
: |
Total Pages |
: 267 |
Release |
: 2014 |
ISBN-10 |
: 1303774410 |
ISBN-13 |
: 9781303774416 |
Rating |
: 4/5 (10 Downloads) |
Synopsis Studies in Asymmetric Synthesis by : Nathan Christopher Thacker
In 1993, the World Health Organization (WHO) declared tuberculosis (TB) a global public emergency. Current drug treatments have reduced the mortality rate 40% since 1990, but increasing numbers of drug-resistant tuberculosis strains have been reported. D-Cyloserine (DCS) is a second line drug for the treatment of TB. In a collaborative effort with Professors Robert Powers (UNL-Chemistry) and Raul Barletta (UNL Veterinary and Biomedical Sciences), experiments with an isotopically-labeled DCS were proposed to elucidate the mechanism. Previously reported routes were not amenable to the milligram quantities available for isotopically labeled serine starting material. The synthetic route that will be described was used to produce both labeled and unlabeled DCS.
Author |
: Dieter Enders |
Publisher |
: John Wiley & Sons |
Total Pages |
: 472 |
Release |
: 2007-04-09 |
ISBN-10 |
: 9783527314737 |
ISBN-13 |
: 3527314733 |
Rating |
: 4/5 (37 Downloads) |
Synopsis Asymmetric Synthesis with Chemical and Biological Methods by : Dieter Enders
Edited by two of the leading researchers in the field, this book provides a deep, interdisciplinary insight into stoichiometric and catalytic reactions in this continuously expanding area. A plethora of top German scientists with an international reputation covers various aspects, from classical organic chemistry to process development, and from the theoretical background to biological methods using enzymes. Throughout the focus is on the development of new synthetic methods in asymmetric synthesis, the synthesis of natural and bioactive compounds and the latest developments in both chemical and biological methods of catalysis, as well as the investigation of special technical and biotechnical aspects.
Author |
: Mathias Christmann |
Publisher |
: John Wiley & Sons |
Total Pages |
: 406 |
Release |
: 2013-03-19 |
ISBN-10 |
: 9783527652259 |
ISBN-13 |
: 3527652256 |
Rating |
: 4/5 (59 Downloads) |
Synopsis Asymmetric Synthesis II by : Mathias Christmann
After the overwhelming success of Asymmetric Synthesis - The Essentials, displaying a broad range of organic asymmetric syntheses, this is the second edition with latest subjects and authors. While the aim of the first edition was mainly to honor the achievements of the pioneers in asymmetric syntheses, the aim of this new edition was bringing the current developments, especially from younger colleagues, to the attention of students. The format of the book remained unchanged, i.e. short conceptual overviews by young leaders in their field including a short biography of the authors. The growing multidisciplinary research within chemistry is reflected in the selection of topics including metal catalysis, organocatalysis, physical organic chemistry, analytical chemistry, and its applications in total synthesis, materials research and industry. The prospective reader of this book is a graduate or undergraduate student of advanced organic chemistry as well as the industrial chemist who wants to get a brief update on the current developments in the field.
Author |
: Xiao-Feng Wu |
Publisher |
: John Wiley & Sons |
Total Pages |
: 596 |
Release |
: 2016-03-07 |
ISBN-10 |
: 9783527338887 |
ISBN-13 |
: 3527338888 |
Rating |
: 4/5 (87 Downloads) |
Synopsis Transition Metal-Catalyzed Heterocycle Synthesis via C-H Activation by : Xiao-Feng Wu
Reflecting the tremendous growth of this hot topic in recent years, this book covers C-H activation with a focus on heterocycle synthesis. As such, the text provides general mechanistic aspects and gives a comprehensive overview of catalytic reactions in the presence of palladium, rhodium, ruthenium, copper, iron, cobalt, and iridium. The chapters are organized according to the transition metal used and sub-divided by type of heterocycle formed to enable quick access to the synthetic route needed. Chapters on carbonylative synthesis of heterocycles and the application of C-H activation methodology to the synthesis of natural products are also included. Written by an outstanding team of authors, this is a valuable reference for researchers in academia and industry working in the field of organic synthesis, catalysis, natural product synthesis, pharmaceutical chemistry, and crop protection.
Author |
: Vittorio Caprio |
Publisher |
: John Wiley & Sons |
Total Pages |
: 409 |
Release |
: 2009-03-09 |
ISBN-10 |
: 9781405190916 |
ISBN-13 |
: 1405190914 |
Rating |
: 4/5 (16 Downloads) |
Synopsis Catalysis in Asymmetric Synthesis by : Vittorio Caprio
Asymmetric synthesis has become a major aspect of modern organic chemistry. The stereochemical properties of an organic compound are often essential to its bioactivity, and the need for stereochemically pure pharmaceutical products is a key example of the importance of stereochemical control in organic synthesis. However, achieving high levels of stereoselectivity in the synthesis of complex natural products represents a considerable intellectual and practical challenge for chemists. Written from a synthetic organic chemistry perspective, this text provides a practical overview of the field, illustrating a wide range of transformations that can be achieved. The book captures the latest advances in asymmetric catalysis with emphasis placed on non-enzymatic methods. Topics covered include: Reduction of alkenes, ketones and imines Nucleophilic addition to carbonyl compounds Catalytic carbon-carbon bond forming reactions Catalytic reactions involving metal carbenoids Conjugate addition reactions Catalysis in Asymmetric Synthesis bridges the gap between undergraduate and advanced level textbooks and provides a convenient point of entry to the primary literature for the experienced synthetic organic chemist.