Bioreactors: Sustainable Design and Industrial Applications in Mitigation of GHG Emissions presents and compares the foundational concepts, state-of-the-art design and fabrication of bioreactors. Solidly based on theoretical fundamentals, the book examines various aspects of the commercially available bioreactors, such as construction and fabrication, design, modeling and simulation, development, operation, maintenance, management and target applications for biofuels production and bio-waste management. Emerging issues in commercial feasibility are explored, constraints and pathways for upscaling, and techno-economic assessment are also covered. This book provides researchers and engineers in the biofuels and waste management sectors a clear, at-a-glance understanding of the actual potential of different advanced bioreactors for their requirements. It is a must-have reference for better-informed decisions when selecting the appropriate technology models for sustainable systems development and commercialization.

The MBR Book

In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.

This concise professional reference provides a fundamental framework for the design and operation of solid-state fermentation bioreactors, enabling researchers currently working at laboratory scale to scale up their processes. The authors survey bioreactor types in common use, and describe in depth how to plan a project, and model heat transfer phenomena. The book includes case studies, and a review of practical issues involved in bioreactor performance.

The book covers the subject of membrane bioreactors (MBR) for wastewater treatment, dealing with municipal as well as industrial wastewaters. The book details the 3 types of MBR available and discusses the science behind the technology, their design features, operation, applications, advantages, limitations, performance, current research activities and cost. As the demand for wastewater treatment, recycling and re-use technologies increases, it is envisaged that the membrane separation bioreactor will corner the market. Contents Membrane Fundamentals Biological Fundamentals Biomass Separation Membrane Bioreactors Membrane Aeration and Extractive Bioreactors Commercial Membrane Bioreactor Systems Membrane Bioreactor Applications Case Studies

Bioreactors are the heart of many biotechnological systems that are used for agriculture, environmental, industrial and medical applications. This book presents the design, properties and applications of bioreactors. Topics discussed include bioreactors for microalgae; application of different types of bioreactors in bioprocesses; airlift bioreactors and its application in fermentation and wastewater treatment; development and deployment of a bioreactor for the removal of sulfate and manganese from circumneutral coal mine drainage and kinetic coefficients and factors affecting aeration efficiency as design parameters of MBR.

The editors of this special volume would first like to thank all authors for their excellent contributions. We would also like to thank Prof. Dr. Thomas Scheper, Dr. Marion Hertel and Ulrike Kreusel for providing the opportunity to compose this volume and Springer for organizational and technical support. Tissue engineering represents one of the major emerging fields in modern b- technology; it combines different subjects ranging from biological and material sciences to engineering and clinical disciplines. The aim of tissue engineering is the development of therapeutic approaches to substitute diseased organs or tissues or improve their function. Therefore, three dimensional biocompatible materials are seeded with cells and cultivated in suitable systems to generate functional tissues. Many different aspects play a role in the formation of 3D tissue structures. In the first place the source of the used cells is of the utmost importance. To prevent tissue rejection or immune response, preferentially autologous cells are now used. In particular, stem cells from different sources are gaining exceptional importance as they can be differentiated into different tissues by using special media and supplements. In the field of biomaterials, numerous scaffold materials already exist but new composites are also being developed based on polymeric, natural or xenogenic sources. Moreover, a very important issue in tissue en- neering is the formation of tissues under well defined, controlled and reprod- ible conditions. Therefore, a substantial number of new bioreactors have been developed.

Bioreactor Design Fundamentals presents the development in the bioreactor field. This book discusses the applications of biological kinetics and thermodynamics. Organized into seven chapters, this book begins with an overview of the design of biological reactors that involves determining operating conditions, sizing the reactor, controlling temperature and sterility, and controlling operating variables. This text then examines the significance of pH considerations in biological reactor and process design. Other chapters consider enzyme kinetics and the equations most commonly used as models for overall enzyme kinetics. This book discusses as well the mass transfer rates in bioreactors, which are significant because of their effects on some chemical reaction rates in transformations by enzymes or by living cells. The final chapter deals with the ideal state of the continuous stirred-tank reactors (CSTRs). This book is a valuable resource for biochemical engineers and industrial microbiologists.

This book deals with monitoring and control of biotechnological processes. Different methods are proposed which are based on the nonlinear structure of the process and do not require any a priori knowledge of the fermentation parameters. The theoretical stability and convergence properties of the proposed algorithms are analysed and their performances are illustrated by simulation results and, in many instances, by real life experiments. The concept of software sensors is introduced; these are algorithms based on the nonlinear model of the process and designed for on-line estimation of the biological variables and/or the fermentation parameters. In order to deal with process nonstationarities and parameter uncertainties, reference is made to adaptive estimation and control techniques.The book is the result of an intensive joint research effort by the authors during the last decade. It is intended as a graduate level text for students of bioengineering as well as a reference text for scientists and engineers involved in the design and optimization of bioprocesses.

This book is concise reference to designing mechanically sound agitation systems that will perform the process function efficiently and economically. Currently, all the books on bioreactor and fermenter design do not focus specifically on agitation. Sections cover agitator fundamentals, impeller systems, optimum power and air flow at peak mass transfer calculations, optimizing operation for minimum energy per batch, heat transfer surfaces and calculations, shaft seal considerations, mounting method, mechanical design, and vendor evaluation.