Recognize market opportunities, master the design process, and develop business acumen with this 'how-to' guide to medical technology innovation. Outlining a systematic, proven approach for innovation - identify, invent, implement - and integrating medical, engineering, and business challenges with real-world case studies, this book provides a practical guide for students and professionals.

Bioluminescent algae, symbiotic aquariums, self-healing concrete, clavicle wind instruments and structures made from living trees - biology applied outside the lab has never been so intriguing, or so beautiful. Bio Design examines the thrilling advances in the field, showcasing some seventy projects (concepts, prototypes and completed designs) that cover a range of fields - from architecture and industrial design to fashion and medicine. The revised and expanded edition features twelve new projects (replacing ten existing projects): Hy-Fi (by David Benjamin); One Central Park, Sydney (Jean Nouvel); Guard from Above (Sjoerd Hoogendoorn); Cell-laden Hydrogels for Biocatalysis (Alshakim Nelson); Zoa (Modern Meadow); Amino Labs (Julie Legault); Algae and Mycelium Projects (Eric Klarenbeek); Interwoven and Harvest (Diane Scherer); Concrete Honey (John Becker); Bistro In Vitro (Koert van Mensvoort); Circumventive Organs (Agi Haines); Quantworm Mine (Liv Bargman and Nina Cutler). It also includes a new 'how-to' section at the end (Tips for Collaboration/FAQs/Further Resources), as well as a fully revised introduction.

Modern biotechnologies give us unprecedented control of the fundamental building blocks of life. For designers, across a range of disciplines, emerging fields such as synthetic biology offer the promise of new sustainable materials and structures which may be grown, are self-assembling, self-healing and adaptable to change. While there is a thriving speculative discourse on the future of design in the age of biotechnology, there are few realized design applications. This book, the first in the Bio Design series, acts as a bridge between design speculation and scientific reality and between contemporary design thinking, in areas such as architecture, product design and fashion design, and the traditional engineering approaches which currently dominate biotechnologies. Filled with real examples, Living Construction reveals how living cells construct and transform materials through methods of fabrication and assembly at multiple scales and how designers can utilize these processes.

Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The textavoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.

The application of CMOS circuits and ASIC VLSI systems to problems in medicine and system biology has led to the emergence of Bio/CMOS Interfaces and Co-Design as an exciting and rapidly growing area of research. The mutual inter-relationships between VLSI-CMOS design and the biophysics of molecules interfacing with silicon and/or onto metals has led to the emergence of the interdisciplinary engineering approach to Bio/CMOS interfaces. This new approach, facilitated by 3D circuit design and nanotechnology, has resulted in new concepts and applications for VLSI systems in the bio-world. This book offers an invaluable reference to the state-of-the-art in Bio/CMOS interfaces. It describes leading-edge research in the field of CMOS design and VLSI development for applications requiring integration of biological molecules onto the chip. It provides multidisciplinary content ranging from biochemistry to CMOS design in order to address Bio/CMOS interface co-design in bio-sensing applications.

Control Systems Design of Bio-Robotics and Bio-Mechatronics with Advanced Applications delivers essential and advanced bioengineering information on the application of control and robotics technologies in the life sciences. Judging by what we have witnessed so far, this exciting field of control systems and robotics in bioengineering is likely to produce revolutionary breakthroughs over the next decade. While this book is intended for senior undergraduate or graduate students in both control engineering and biomedical engineering programs, it will also appeal to medical researchers and practitioners who want to enhance their quantitative understanding of physiological processes. - Focuses on the engineering and scientific principles underlying the extraordinary performance of biomedical robotics and bio-mechatronics - Demonstrates the application of principles for designing corresponding algorithms - Presents the latest innovative approaches to medical diagnostics and procedures, as well as clinical rehabilitation from the point-of-view of dynamic modeling, system analysis and control

The effective design of scientific experiments is critical to success, yet graduate students receive very little formal training in how to do it. Based on a well-received course taught by the author, Experimental Design for Biologistsfills this gap. Experimental Design for Biologistsexplains how to establish the framework for an experimental project, how to set up a system, design experiments within that system, and how to determine and use the correct set of controls. Separate chapters are devoted to negative controls, positive controls, and other categories of controls that are perhaps less recognized, such as “assumption controls†and “experimentalist controls†. Furthermore, there are sections on establishing the experimental system, which include performing critical “system controls†. Should all experimental plans be hypothesis-driven? Is a question/answer approach more appropriate? What was the hypothesis behind the Human Genome Project? What color is the sky? How does one get to Carnegie Hall? The answers to these kinds of questions can be found in Experimental Design for Biologists. Written in an engaging manner, the book provides compelling lessons in framing an experimental question, establishing a validated system to answer the question, and deriving verifiable models from experimental data. Experimental Design for Biologistsis an essential source of theory and practical guidance in designing a research plan.

-To provide insight to the process which engages nature and design, this collection of work shines light on the educational methods currently being explored in China's top institutions Bio-inspired design is both simple and complex. Simple because it provides an easy reference to discuss ideas through a means we all can relate to and become inspired by - the natural world. The topic engages a spectrum of professionals, from environmental enthusiasts to design professionals and scientists. The complexity arises when we need to understand beyond what we see and understand how nature works. At many levels, we are still exploring how systems are inter-related and to decipher these relationships we have to look beyond the idealized inspiration. Throughout the world, research and development that focuses on bio-inspiration has been steadily increasing and is expected to continue to do so for the next two decades. Currently, China is one of the leaders in scholarly articles focusing on bio-inspiration. Although this topic is developing at an impressive rate, much of the public awareness of bio-inspiration and similar areas of research such as biomimetics and biomimicry is relatively unknown. Therefore, to provide insight into this process, this collection of work shines light on the methods currently being explored in China's top institutions.

This richly illustrated book provides an overview of the design and analysis of experiments with a focus on non-clinical experiments in the life sciences, including animal research. It covers the most common aspects of experimental design such as handling multiple treatment factors and improving precision. In addition, it addresses experiments with large numbers of treatment factors and response surface methods for optimizing experimental conditions or biotechnological yields. The book emphasizes the estimation of effect sizes and the principled use of statistical arguments in the broader scientific context. It gradually transitions from classical analysis of variance to modern linear mixed models, and provides detailed information on power analysis and sample size determination, including ‘portable power’ formulas for making quick approximate calculations. In turn, detailed discussions of several real-life examples illustrate the complexities and aberrations that can arise in practice. Chiefly intended for students, teachers and researchers in the fields of experimental biology and biomedicine, the book is largely self-contained and starts with the necessary background on basic statistical concepts. The underlying ideas and necessary mathematics are gradually introduced in increasingly complex variants of a single example. Hasse diagrams serve as a powerful method for visualizing and comparing experimental designs and deriving appropriate models for their analysis. Manual calculations are provided for early examples, allowing the reader to follow the analyses in detail. More complex calculations rely on the statistical software R, but are easily transferable to other software. Though there are few prerequisites for effectively using the book, previous exposure to basic statistical ideas and the software R would be advisable.