A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

For the first time the lay public can benefit from the anti-aging secrets discovered by the Life Extension Foundation, the world’s largest, most respected organization dedicated to anti-aging research. Working with the Life Extension Foundation, renowned anti-aging physician Philip Lee Miller shows you how to retain your physical health and vigor, mental clarity, and youthful appearance–for life. This groundbreaking book translates cutting-edge anti-aging advances into a practical, easy-to-use program that will maximize your chances of living not only a long life–but a healthy, vibrant life. Drawing on his own clinical experience as well as the latest research from the Life Extension Foundation, Dr. Miller demystifies the aging process and provides you with: •Detailed strategies integrating the most advanced mainstream therapies with nutrients, hormones, and holistic approaches from around the world •A comprehensive plan to protect yourself from cancer, heart disease, arthritis, and Alzheimer’s disease at the cellular level by controlling inflammation and oxidation–two degenerative processes that cause us to age prematurely •A guide to individualizing this lifesaving program, including the Longevity Diet for maximum vitality and effortless weight loss and a unique supplement regimen–plus how to use medical tests to monitor your progress •An inspiring vision of the future of life extension science and what your future will be like without disease, premature death and aging–with novel strategies to help you get there This far-reaching anti-aging program will change your life forever. Like many of Dr. Miller’s patients, your physical and mental health will actually soar as you age chronologically. Your new longer, healthier life begins now as you embark on The Life Extension Revolution.

How do some people avoid the slowing down, deteriorating, and weakening that plagues many of their peers decades earlier? Are they just lucky? Or do they know something the rest of us don’t? Is it possible to grow older without getting sicker? What if you could look and feel fifty through your eighties and nineties? Founder of the Institute for Aging Research at the Albert Einstein College of Medicine and one of the leading pioneers of longevity research, Dr. Nir Barzilai’s life’s work is tackling the challenges of aging to delay and prevent the onset of all age-related diseases including “the big four”: diabetes, cancer, heart disease, and Alzheimer’s. One of Dr. Barzilai’s most fascinating studies features volunteers that include 750 SuperAgers—individuals who maintain active lives well into their nineties and even beyond—and, more importantly, who reached that ripe old age never having experienced cardiovascular disease, cancer, diabetes, or cognitive decline. In Age Later, Dr. Barzilai reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process. This eye-opening and inspirational book will help you think of aging not as a certainty, but as a phenomenon—like many other diseases and misfortunes—that can be targeted, improved, and even cured.

Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points prior to human studies. This book provides an overview of current research aimed to search for life-extending medications and describes pharmacological aspects of anti-aging medicine. Readers are introduced to the fascinating historical background of geroprotection in the first chapter. In-depth information on models for investigating geroprotective drugs precedes a section covering anti-aging properties of pharmaceutical compounds, such as calorie restriction mimetics, autophagy inducers, senolytics and mitochondrial antioxidants. Finally, strategies to translate discoveries from aging research into drugs and healthcare policy perspectives on anti-ageing medicine are provided to give a complete picture of the field. A timely and carefully edited collection of chapters by leading researchers in the field, this book will be a fascinating and useful resource for pharmacologists, gerontologists and any scientifically interested person wishing to know more about the current status of research into anti-aging remedies, challenges and opportunities.

Discusses various aspects of aging and includes suggestions on how to slow the aging process and improve your health.

Aging is a treatable condition! For more than a century aging and a particular lifespan have been widely thought to be an inescapable and fundamental aspect of human existence. Indeed, Darwin's evolution theory tells us that the force of evolution is toward defeating aging, leading to the idea that aging is the result of unalterable laws of physics or chemistry. We can find different treatments for different age-related diseases like cancer and heart disease but aging is itself an untreatable fact of life. Today it is increasingly clear that aging is actually the result of complex biological programs that purposely limit lifespan in humans and most animals because this created an evolutionary advantage for populations of wild animals including our prehistoric ancestors. Programmed aging and supporting evolutionary concepts are a logical consequence of relatively recent discoveries in genetics as well as observations regarding the aging and lifespan characteristics of many different organisms. As a consequence, we can increase healthy human lifespan by interfering with the aging program. Interfering with a biological process is a familiar problem in medicine, and research toward developing treatments based on this idea are underway. Goldsmith describes the 160-year history of still-unresolved scientific arguments over the evolutionary nature of aging, the increasing empirical evidence of aging programs, and the exciting prospects for lifespan extension and healthy living. More practically, the book describes: Key observations about the nature of aging. Orally administered substances known to increase longevity in mice. Why exercise increases longevity. Anti-aging medicine issues with existing health care systems. Social, educational, ethical, and economic issues with extending lifespan. How lifespan extension concepts add to our ability to devise treatments for age-related diseases. Contents 1. Introduction 2. Nature of Aging and Lifespan 3. Evolution Theory and Aging 4. Evidence Supporting Programmed Aging 5. U.S. Health System Summary 6. Exercise and Activity - Effects on Aging 7. Non-Science Factors Favor Non-Programmed Aging 8. Programmed vs Non-Programmed Aging - Current Status 9. Anti-Aging Research 10. Anti-Aging Medicine 11. Conclusion 12. Free Resources and Further Reading 13. Author's Notes 14. Appendix 15. Glossary 16. References

Slow down the aging process and live well for longer Do you know exactly how and why you age? And what you can do—whatever your current age—to slow that process and have a longer, healthier life? In The Longevity Code, medical doctor Kris Verburgh illuminates the biological mechanisms that make our bodies susceptible to heart attacks, dementia, diabetes, and other aging-related diseases. With the facts laid out, he provides the tools we need to slow down the aging process. His scientifically backed Longevity Staircase outlines a simple yet innovative step-by-step method offering better health and a longer life span– especially the crucial role of proper nutrition and exercise. But diet and exercise might not be the only way to crack the “longevity code”: With each passing day, advances in biotechnology that were once the stuff of science fiction are emerging. Dr. Verburgh discusses how new types of vaccines, mitochondrial DNA, CRISPR proteins, and stem cells may help us slow and even reverse aging—now and in the future—and when paired with the right lifestyle, lead to longer, healthier lives than we’ve ever imagined.

Why do we age? The answer to this question is critical to our ability to prevent and treat highly age-related diseases such as cancer and heart disease that now cause the deaths of most people in the developed world. This short book provides an overview of biological aging theories including history, current status, major scientific controversies, and implications for the future of medicine. Major topics include: human mortality as a function of age, aging mechanisms and processes, the programmed vs. non-programmed aging controversy, empirical evidence on aging, and the feasibility of anti-aging and regenerative medicine. Evolution theory is essential to aging theories. Theorists have been struggling for 150 years to explain how aging, deterioration, and consequent death fit with Darwin’s survival of the fittest concept. This book explains how continuing genetics discoveries have produced changes in the way we think about evolution that in turn lead to new thinking about the nature of aging.

The New York Times bestselling book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life. Have you wondered why some sixty-year-olds look and feel like forty-year-olds and why some forty-year-olds look and feel like sixty-year-olds? While many factors contribute to aging and illness, Dr. Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. They and other scientists have found that changes we can make to our daily habits can protect our telomeres and increase our health spans (the number of years we remain healthy, active, and disease-free). The Telemere Effect reveals how Blackburn and Epel's findings, together with research from colleagues around the world, cumulatively show that sleep quality, exercise, aspects of diet, and even certain chemicals profoundly affect our telomeres, and that chronic stress, negative thoughts, strained relationships, and even the wrong neighborhoods can eat away at them. Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. And they describe how we can improve our health spans at the community level, with neighborhoods characterized by trust, green spaces, and safe streets. The Telemere Effect will make you reassess how you live your life on a day-to-day basis. It is the first book to explain how we age at a cellular level and how we can make simple changes to keep our chromosomes and cells healthy, allowing us to stay disease-free longer and live more vital and meaningful lives.

___ ***SHORTLISTED FOR THE ROYAL SOCIETY SCIENCE BOOK PRIZE 2022*** Did you know that we can lead longer and healthier lives by making simple changes right now? Professor Rose Anne Kenny has 35 years of experience at the forefront of ageing medicine. In Age Proof, she draws on her own pioneering research and the latest evidence to demystify why we age and shows us that 80% of our ageing biology is within our control: we can not only live longer lives but become happier and healthier deep into our later years. Effortlessly distilling scientific theory into practical advice that we can apply to our everyday lives, Professor Kenny examines the impact that food, genetics, friendships, purpose, sex, exercise and laughter have on how our cells age. This illuminating book will show you the steps you can take to stay younger for longer - and will prove that you really are just as young as you feel.