Pituitary Adenylate Cyclase-Activating Polypeptide is the first volume to be written on the neuropeptide PACAP. It covers all domains of PACAP from molecular and cellular aspects to physiological activities and promises for new therapeutic strategies. Pituitary Adenylate Cyclase-Activating Polypeptide is the twentieth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.

This book offers physiology teachers a new approach to teaching their subject that will lead to increased student understanding and retention of the most important ideas. By integrating the core concepts of physiology into individual courses and across the entire curriculum, it provides students with tools that will help them learn more easily and fully understand the physiology content they are asked to learn. The authors present examples of how the core concepts can be used to teach individual topics, design learning resources, assess student understanding, and structure a physiology curriculum.

August Krogh, the son of a brewer, studied zoology in Copenhagen and earned his doctoral degree under the physiologist Christian Bohr, the father of the world-renowned nuclear physicist Niels Bohr. Krogh's unusual ability to construct instruments and complex apparatuses and his intuitive understanding of physical principles made it possible for him to improve on Bohr's methods. His findings led him to challenge Christian Bohr's ideas about oxygen secretion, and when Bohr refused to accept his findings, Krogh unwillingly came into a painful conflict with his own mentor. Krogh's continued studies of how oxygen is supplied to the tissues led to his realization that the blood flow in the finest blood vessels, the capillaries, has to be regulated through a mechanism that opens and closes the capillaries according to the tissue's need for oxygen. This idea and his scientific proof were at the time so new and revolutionary that he was promptly (in 1920) awarded the Nobel Prize. His fame in Denmark and all over the world continued to grow until his death in 1949. His scientific discoveries extended from respiration, exercise physiology and capillary physiology into comparative osmoregulation, isotope studies, active transport of ions in plants and animals, and finally insect flight. Another dramatic story of Krogh's life began when he introduced insulin production in Denmark in 1922. This move saved his own wife's life as well as numerous other lives and helped make Denmark's Novo-Nordisk the largest producer of insulin in the world today. Krogh's wife, Marie, became a physician and a renowned scientist in her own right. Throughout their harmonious marriage and partnership, Marie played an important role in her husband's life both scientifically and personally. Written by the proud daughter of August and Marie Krogh, this biography is based on numerous letters, scientific papers, interviews, symposia, and other sources as well as the author's own knowledge of her parents. The intertwining of the scientific work and personal lives of these two remarkable people is beautifully illustrated in a well-rounded picture of their struggles and triumphs. It is a unique book, full of human warmth and scientific understanding.

ACSM’s Clinical Exercise Physiology adapts and expands upon the disease-related content from ACSM’s Resource Manual for Guidelines for Exercise Testing and Prescription, 7th Edition, to create a true classroom textbook. This new resource offers research-based coverage of more than 35 conditions commonly seen in practice—from a host of cardiovascular disorders to immunological/hematological disorders. Condition chapters are organized by disease types and then divided into sections that cover specific conditions from a pathological and etiological perspective. To provide a complete view of clinical exercise physiology, the book also covers important considerations and foundational elements, such as screening, pharmacology, and electrocardiography. As an American College of Sports Medicine publication, the text offers the unsurpassed quality and excellence that has become synonymous with titles by the leading exercise science organization in the world.

I know that most men, including those at ease with the problems of the greatest complexity, can seldom accept even the simplest and most obvious truth if it be such as would oblige them to admit the falsity of conclusions which they have delighted in explaining to colleagues, which they have proudly taught to others, and which they have woven, thread by thread, into the fabric of their lives. Joseph Ford quoting Tolstoy (Gleick, 1987) We are used to thinking that natural objects have a certain form and that this form is determined by a characteristic scale. If we magnify the object beyond this scale, no new features are revealed. To correctly measure the properties of the object, such as length, area, or volume, we measure it at a resolution finer than the characteristic scale of the object. We expect that the value we measure has a unique value for the object. This simple idea is the basis of the calculus, Euclidean geometry, and the theory of measurement. However, Mandelbrot (1977, 1983) brought to the world's attention that many natural objects simply do not have this preconceived form. Many of the structures in space and processes in time of living things have a very different form. Living things have structures in space and fluctuations in time that cannot be characterized by one spatial or temporal scale. They extend over many spatial or temporal scales.

Human Physiology, Biochemistry and Basic Medicine is a unique perspective that draws together human biology, physiology, biochemistry, nutrition, and cell biology in one comprehensive volume. In this way, it is uniquely qualified to address the needs of the emerging field of humanology, a holistic approach to understanding the biology of humans and how they are distinguished from other animals. Coverage starts with human anatomy and physiology and the details of the workings of all parts of the male and female body. Next, coverage of human biochemistry and how sugars, fats, and amino acids are made and digested is discussed, as is human basic medicine, covering the science of diseases and human evolution and pseudo-evolution. The book concludes with coverage of basic human nutrition, diseases, and treatments, and contains broad coverage that will give the reader an understanding of the entire human picture. - Covers the physiology, anatomy, nutrition, biochemistry and cell biology of humans, showing how they are distinguished from other animals - Includes medical literature and internet references, example test questions, and a list of pertinent words at the end of each chapter - Provides unique perspective into all aspects of what makes up and controls humans

Preclinical Speech Science: Anatomy, Physiology, Acoustics, and Perception, Third Edition is a high-quality text for undergraduate and graduate courses in speech and hearing science. Written in a user-friendly style by distinguished scientists/clinicians who have taught the course to thousands of students at premier academic programs, it is the text of choice for instructors and students. Additionally, it is applicable to a broad range of courses that cover the anatomy and physiology of speech production, speech acoustics, and swallowing as well as those that cover the hearing mechanism, psychoacoustics, and speech perception. The material in this book is designed to help future speech-language pathologists and audiologists to understand the science that underpins their work and provide a framework for the evaluation and management of their future clients. It provides all the information students need to be fully ready for their clinical practicum training. KEY FEATURES: Describes scientific principles explicitly and in translational terms that emphasize their relevance to clinical practice.Features beautiful original, full-color illustrations designed to be instructive learning tools.Incorporates analogies that aid thinking about processes from different perspectives.Features "sidetracks" that contain clinical insights and relate interesting historical and contemporary facts to the discipline of speech and hearing science.Provides a framework for conceptualizing the uses, subsystems, and levels of observation of speech production, hearing, and swallowing.Includes material that is ideal for preparing both undergraduates and graduates for clinical study. NEW TO THE THIRD EDITION: Three new, up-to-date, and comprehensive chapters on auditory anatomy and physiology, auditory psychophysics, and speech physiology measurement and analysis.All chapters fully revised, including updated references and new full-color, detailed images.*Disclaimer: Please note that ancillary content (such as documents, audio, and video, etc.) may not be included as published in the original print version of this book.

Prolonged microgravity exposure during long-duration spaceflight (LDSF) produces unusual physiologic and pathologic neuro-ophthalmic findings in astronauts. These microgravity-associated findings collectively define the Spaceflight Associated Neuro-ocular Syndrome (SANS). In this book, the editors compare and contrast prior published work on SANS by the National Aeronautics and Space Administration's (NASA) Space Medicine Operations Division with retrospective and prospective studies from other research groups. The book describes the possible mechanisms and potential etiologies for SANS, and provides an update and review on the clinical manifestations of SANS including: unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and focal areas of ischemic retina (i.e., cotton wool spots). The ocular imaging findings (e.g., retinal nerve fiber layer, optic disc, and choroidal changes on optical coherence tomography) of SANS is also described, including the intraorbital and intracranial findings on orbital ultrasound and magnetic resonance imaging. The knowledge gaps for in-flight and terrestrial human research including potential countermeasures for future stud is also explored, including reports on the in-flight and terrestrial human and animal research being investigated by NASA and its partners to study SANS both prospectively and longitudinally and in preparation for future long duration manned missions to space including the moon, the asteroid belt, or Mars. We think this is a unique topic and hope that NASA and its research partners continue to study SANS in preparation for future longer duration manned space missions. - Written in an easy-to-read manner, the book adopts a translational approach and explores the science and the clinical manifestations of Space flight associated neuro-ocular syndrome. It is also multi-disciplinary and suitable for both clinicians and researchers in ophthalmology, neurology, and aerospace medicine interested in SANS - SANS is a unique space flight disorder that has no terrestrial equivalent. The book involves contributions from international experts across multiple disciplines to tackle the problem of SANS - Summarizes and reviews the current findings of SANS, including possible mechanisms and potential etiologies, clinical manifestations, current reports on the in-flight and terrestrial human and animal research, and ocular imaging findings

The new edition of Human Physiology - an Oxford Core Text continues to meet the needs of preclinical medical students and is also of value to those following undergraduate courses in physiology and other health-related disciplines. It adopts a student-friendly style with an emphasis on clarity, explanation and understanding complemented by full-color illustrations. The book has a hierarchical organization, beginning with aspects of cell and tissue function before proceeding to a consideration of the communication systems of the body including the endocrine and nervous systems. The heart of the text concerns the physiology of the main body systems. The new edition has been significantly revised to include an expanded problem section at the end of each chapter with more quantitative examples and some clinical problems where appropriate. Each chapter has been updated and new material includes a section on the physiology of itch; more detailed treatment of colour vision, deafness and vestibular blindness; increased emphasis on neurology disorders; discussion of the physiology of respiratory failure and pulmonary embolism; a discussion of malabsorption disorders; extensive revision to cover the wider aspects of material physiology not just lactation, and extended treatment of fever. The Clinical Physiology chapter is now broken into several short chapters and includes a discussion of cardiovascular pathophysiology and organ failure.