How can healthcare systems be transformed by reimagining their multiple silos to favor processes and practices that are more responsive to local, horizontal initiatives? Altering Frontiers analyzes numerous experiences, using a multidisciplinary approach, paying attention to certain actors, collectives and organizational arrangements. Through this work, levers are identified that promote lasting transformation: recognizing the legitimacy of the practices of many who are often "invisible"; trusting those who know their intervention territory; investing in methodological support; taking advantage of tools and procedures such as instruments for strategic and managerial discussion; and developing the capacity to absorb innovative ideas and experiences that circulate within the environment.

In 1945, Vannevar Bush, founder of Raytheon and one-time engineering dean at MIT, delivered a report to the president of the United States that argued for the importance of public support for science, and the importance of science for the future of the nation. The report, Science: The Endless Frontier, set America on a path toward strong and well-funded institutions of science, creating an intellectual architecture that still defines scientific endeavor today. In The Changing Frontier, Adam B. Jaffe and Benjamin Jones bring together a group of prominent scholars to consider the changes in science and innovation in the ensuing decades. The contributors take on such topics as changes in the organization of scientific research, the geography of innovation, modes of entrepreneurship, and the structure of research institutions and linkages between science and innovation. An important analysis of where science stands today, The Changing Frontier will be invaluable to practitioners and policy makers alike.

From their inception, video games quickly became a major new arena of popular entertainment. Beginning with very primitive games, they quickly evolved into interactive animated works, many of which now approach film in terms of their visual excitement. But there are important differences, as Arthur Asa Berger makes clear in this important new work. Films are purely to be viewed, but video involves the player, moving from empathy to immersion, from being spectators to being actively involved in texts. Berger, a renowned scholar of popular culture, explores the cultural significance of the expanding popularity and sophistication of video games and considers the biological and psychoanalytic aspects of this phenomenon. Berger begins by tracing the evolution of video games from simple games like Pong to new, powerfully involving and complex ones like Myst and Half-Life. He notes how this evolution has built the video industry, which includes the hardware (game-playing consoles) and the software (the games themselves), to revenues comparable to the American film industry. Building on this comparison, Berger focuses on action-adventure games which, like film and fiction, tell stories but which also involve culturally important departures in the conventions of narrative. After defining a set of bipolar oppositions between print and electronic narratives, Berger considers the question of whether video games are truly interactive or only superficially so, and whether they have the potential to replace print narratives in the culture at large. A unique dimension of the book is its bio-psycho-social analysis of the video game phenomenon. Berger considers the impact of these games on their players, from physical changes (everything from neurological problems to obesity) to psychological consequences, with reference to violence and sexual attitudes. He takes these questions further by examining three enormously popular games-Myst/Riven, Tomb Raider, and Half-Life-for their attitudes toward power, gender, violence, and guilt. In his conclusion, Berger concentrates on the role of violence in video games and whether they generate a sense of alienation in certain addicted players who become estranged from family and friends. Accessibly written and broad-ranging in approach, Video Games offers a way to interpret a major popular phenomenon.

In Frontier Fictions, Firoozeh Kashani-Sabet looks at the efforts of Iranians to defend, if not expand, their borders in the nineteenth and early twentieth centuries, and explores how their conceptions of national geography influenced cultural and political change. The "frontier fictions," or the ways in which the Iranians viewed their often fluctuating borders and the conflicts surrounding them, played a dominant role in defining the nation. On these borderlands, new ideas of citizenship and nationality were unleashed, refining older ideas of ethnicity. Kashani-Sabet maintains that land-based conceptions of countries existed before the advent of the modern nation-state. Her focus on geography enables her to explore and document fully a wide range of aspects of modern citizenship in Iran, including love of homeland, the hegemony of the Persian language, and widespread interest in archaeology, travel, and map-making. While many historians have focused on the concept of the "imagined community" in their explanations of the rise of nationalism, Kashani-Sabet is able to complement this perspective with a very tangible explanation of what connects people to a specific place. Her approach is intended to enrich our understanding not only of Iranian nationalism, but also of nationalism everywhere.

How can healthcare systems be transformed by reimagining their multiple silos to favor processes and practices that are more responsive to local, horizontal initiatives? Altering Frontiers analyzes numerous experiences, using a multidisciplinary approach, paying attention to certain actors, collectives and organizational arrangements. Through this work, levers are identified that promote lasting transformation: recognizing the legitimacy of the practices of many who are often "invisible"; trusting those who know their intervention territory; investing in methodological support; taking advantage of tools and procedures such as instruments for strategic and managerial discussion; and developing the capacity to absorb innovative ideas and experiences that circulate within the environment.

The term “synaptic plasticity” is a broad concept, which is studied with a variety of experimental approaches. One focus is the impact of changes in synaptic, neuronal and glial morphology on brain circuitry and behavior. In this regard, unique animal models have been key to the study of affective and social behaviors and neurological and psychiatric diseases. However, there is a paucity of compilations directed toward the correlation of alterations in synaptic structure with various physiological and behavioral paradigms. This Frontiers Research Topic will, therefore, serve as an exciting forum for the exchange of novel hypotheses and data and an important resource and reference for investigators studying synaptic and brain plasticity, as well as those in related fields.

The polar regions are experiencing rapid changes in climate. These changes are causing observable ecological impacts of various types and degrees of severity at all ecosystem levels, including society. Even larger changes and more significant impacts are anticipated. As species respond to changing environments over time, their interactions with the physical world and other organisms can also change. This chain of interactions can trigger cascades of impacts throughout entire ecosystems. Evaluating the interrelated physical, chemical, biological, and societal components of polar ecosystems is essential to understanding their vulnerability and resilience to climate forcing. The Polar Research Board (PRB) organized a workshop to address these issues. Experts gathered from a variety of disciplines with knowledge of both the Arctic and Antarctic regions. Participants were challenged to consider what is currently known about climate change and polar ecosystems and to identify the next big questions in the field. A set of interdisciplinary "frontier questions" emerged from the workshop discussions as important topics to be addressed in the coming decades. To begin to address these questions, workshop participants discussed the need for holistic, interdisciplinary systems approach to understanding polar ecosystem responses to climate change. As an outcome of the workshop, participants brainstormed methods and technologies that are crucial to advance the understanding of polar ecosystems and to promote the next generation of polar research. These include new and emerging technologies, sustained long-term observations, data synthesis and management, and data dissemination and outreach.