According to the 2018 National Survey on Drug Use and Health, 14.4 million adults aged 18 and older had alcohol use disorder (AUD). Mixing alcohol with other drugs such as opioids or cocaine has become an emerging trend, exacerbating public health concerns and may synergistically augment the seriousness of the adverse effects such as withdrawal symptoms, cardiovascular disorders, liver damage, reproductive abnormalities, and behavioral abnormalities. Despite the seriousness of the situation, possible mechanisms underlying the addiction and the withdrawal symptoms is not yet understood. This has been one of the key hindrances in developing effective treatment. Neurobiology of Alcohol and the Brain addresses the addiction-related problems reviewing both the mechanisms and withdrawal system with alcohol addiction. First, the book discusses the mechanisms of the rewarding and aversive effects, including addiction and the withdrawal symptoms of alcohol drinking. Next, alcohol's interaction with other drugs and ensuing adverse consequences is discussed including current and novel treatments against alcoholism. This is followed by a closer look at mental health and alcohol use disorder comorbidity. Lastly, the reader is provided with examples of an experimental study that describes possible protective effects of gold nanoparticles against alcohol addiction in rats subjected to alcohol self-administration. Neurobiology of Alcohol and the Brain will unlock the mechanistic diversities of alcoholism helping to facilitate future developments of new, personalized treatment options for patients suffering from alcohol addiction. Provides an exhaustive overview of neurobiology of alcohol addiction, including significant recent advances Discusses the mechanisms underlying the adverse effects of alcohol-drug mixtures Includes recent experimental studies on gold nanoparticles

An understanding of the nature and progression of alcohol addiction has emerged: alcoholism as the result of an imbalance in the brain's natural production of neurotransmitters critical to our sense of wellbeing. This imbalance, which an increasing amount of evidence is demonstrating to be genetically influenced, produces a craving temporarily satisfied by drinking. Alcohol and the Addictive Brain is an account of the scientific discoveries concerning alcoholism.

Scientific research has clearly established that drinking in moderation has many health benefits, including maintaining a healthy heart. Yet, many people do not know that drinking red wine protects the heart more than white wine, while beer, margaritas, and hard liquor are less effective in providing such protection. And while alcoholism is a serious problem requiring medical and psychological treatment, for those who are not addicted, drinking alcohol is not necessarily a bad habit. The problem is to distinguish between drinking sensibly and drinking insensibly. Dasgupta clearly outlines what constitutes healthy drinking and its attendant health benefits, offers advice on how to drink responsibly, and provides insight into just how alcohol works on the brain and the body. After reading this book, readers will enjoy their next drink with a fuller and safer understanding of why they're enjoying it.

Hijacking the Brain provides the first-ever scientific explanation for the success of Twelve-Step programs. Hijacking the Brain examines data provided by recent rapid growth in the fields of neuroscience, neuroimaging, psychology, sociobiology and interpersonal neurobiology that have given us new, dramatic insights into the neural and hormonal correlates of stress and addiction, cognitive decline with addiction, as well as for the relative success of Twelve-Step Programs of recovery. Addiction is recognized by experts as an organic brain disease, and most experts promote Twelve-Step programs (AA, NA, CA, etc.) which invoke a 'spiritual solution' for recovery. To date, no one has described why these programs work. 'Hijack' tells us why. In 'Hijack, ' the role of 'working The Steps' for reducing stress and becoming emotionally centered is discussed in depth. A full chapter is devoted to the rewarding and comforting physiology of meditation and the spiritual experience. The author uses examples from animal sociobiology, as well as sophisticated human brain-imaging studies, to demonstrate that empathic socialization and altruism are instinctive and 'naturally rewarding' and, along with Step Work, act as a substitute for the 'synthetic rewards' of drugs of abuse. 'Hijack' does not challenge the Steps or the Traditions of Twelve-Step programs. The sole intention of Hijacking the Brain is to 'connect the dots' between an 'organic brain disease' and a 'spiritual solution' with sound physical, scientific evidence. Avoiding strict scientific language as much as possible, 'Hijack' is written for the layperson and abundantly illustrated.

"The Addicted Brain" explains clearly and vividly what has been learned about how and why some people become addicted and abuse drugs or other substances, the relatively long-term changes these substances can make in the brain, and the progress being made on treatments.

Recent years have seen more systematic investigations of the consequences of prenatal and early postnatal exposure to alcohol for brain and behavioral development. Offers an overview of what they have shown, and points out directions for further research

Alcohol use by young people is extremely dangerous - both to themselves and society at large. Underage alcohol use is associated with traffic fatalities, violence, unsafe sex, suicide, educational failure, and other problem behaviors that diminish the prospects of future success, as well as health risks â€" and the earlier teens start drinking, the greater the danger. Despite these serious concerns, the media continues to make drinking look attractive to youth, and it remains possible and even easy for teenagers to get access to alcohol. Why is this dangerous behavior so pervasive? What can be done to prevent it? What will work and who is responsible for making sure it happens? Reducing Underage Drinking addresses these questions and proposes a new way to combat underage alcohol use. It explores the ways in which may different individuals and groups contribute to the problem and how they can be enlisted to prevent it. Reducing Underage Drinking will serve as both a game plan and a call to arms for anyone with an investment in youth health and safety.

U.S. census figures forecast that the percentage of U.S. citizens over the age of 65 will double between 1980 and 2030. Estimates that between 3 and 10% of this group are prone to alcohol abuse points to the potential for an increasingly ominous health care problem. Alcohol and Aging, the first comprehensive treatment of the topic written for clinicians, covers a wide range of issues unique to elderly alcoholics, from diagnosis and treatment to alcohol-related medical and cognitive disorders, from problems arising from interactions between alcohol and medication to the biochemistry of intoxication. Throughout, the book focuses on clinical, practical problems and stays away from jargon, making it accessible to a wide range of readers. Featuring contributions a diverse group of specialists, the book will be an invaluable aid to physicians, psychiatrists, clinical psychologists, and social workers who treat alcoholism in the aging population.

MRI Atlas of Human White Matter presents an atlas to the human brain on the basis of T 1-weighted imaging and diffusion tensor imaging. A general background on magnetic resonance imaging is provided, as well as the basics of diffusion tensor imaging. An overview of the principles and limitations in using this methodology in fiber tracking is included. This book describes the core white-matter structures, as well as the superficial white matter, the deep gray matter, and the cortex. It also presents a three-dimensional reconstruction and atlas of the brain white-matter tracts. The Montreal Neurological Institute coordinates, which are the most widely used, are adopted in this book as the primary coordinate system. The Talairach coordinate system is used as the secondary coordinate system. Based on magnetic resonance imaging and diffusion tensor imaging, the book offers a full segmentation of 220 white-matter and gray-matter structures with boundaries. - Visualization of brain white matter anatomy via 3D diffusion tensor imaging (DTI) contrasts and enhances relationship of anatomy to function - Full segmentation of 170+ brain regions more clearly defines structure boundaries than previous point-and-annotate anatomical labeling, and connectivity is mapped in a way not provided by traditional atlases