African Flora to Fight Bacterial Resistance, Part One: Standards for the Activity of Plant-Derived Products offers a glimpse into the potential of African medicinal plants to fight bacterial infections, with an emphasis on bacterial drug resistance. Sample chapters cover the Global Burden of bacterial infections and drug resistance, Bacterial drug resistance towards natural products, Harvesting and Processing Medicinal plants for antibacterial testing, Screening methods for antibacterial agents from plant source, Established antibacterial drugs from plants, Potential of African medicinal plants against Enterobacteria: classification of plants antibacterial agents, and much more. Based on collected data, the book offers a rationale classification basis for the antibacterial activity of plant-based products. General knowledge of state-of-the-art of drug resistance is globally described, with the book clearly identifying the best African medicinal plants that could be useful for the development of efficient herbal drugs, as well as the best phytochemicals that could be explored as potential pharmaceuticals. - Provides the first book of its type to focus on the potential of African plants as alternative medicine against bacterial drug resistance - Analyzes the recorded data to propose a well-elaborated basis for the classification of antibacterial agents from plants - Clearly identifies and discusses plants and phytochemicals that could be useful in the development of new antibacterial drugs to combat drug resistance

African Flora to Fight Bacterial Resistance, Part Two: The Best Source of Herbal Drugs and Pharmaceuticals, Volume 107 offers detailed information on the best African medicinal plants that could be useful for the development of efficient herbal drugs, as well as the best phytochemicals that could be explored as potential pharmaceuticals to efficiently tackle bacterial drug resistance. Chapters cover Phytochemistry and antibacterial potential of the genus Allanblackia, Phytochemistry and antibacterial potential of the genus Beilschmiedia, Phytochemistry and antibacterial potential of the genus Fagara, Phytochemistry and antibacterial potential of the genus Garcinia, Harungana madagascariensis as a source of antibacterial agents, Hypericum roeperianum as a source of antibacterial agents, and much more. - Provides a unique resource and compilation of the best African plants with amazing potential against multidrug-resistant bacteria - Discusses, in detail, the antibacterial potential of the best phytochemicals identified in African plants against multidrug-resistant bacteria - Compiles the ethnomedicinal, pharmacological and phytochemistry information of the best antibacterial African plants and their most potent phytochemicals

The pharmacopoeias of most African countries are available and contain an impressive number of medicinal plants used for various therapeutic purposes. Many African scholars have distinguished themselves in the fields of organic chemistry, pharmacology, and pharmacognosy and other areas related to the study of plant medicinal plants. However, until now, there is no global standard book on the nature and specificity of chemicals isolated in African medicinal plants, as well as a book bringing together and discussing the main bioactive metabolites of these plants. This book explores the essence of natural substances from African medicinal plants and their pharmacological potential. In light of possible academic use, this book also scans the bulk of African medicinal plants extract having promising pharmacological activities. - The book contains data of biologically active plants of Africa, plant occurring compounds and synthesis pathways of secondary metabolites - This book explores the essence of natural substances from African medicinal plants and their pharmacological potential - The authors are world reknowned African Scientists

African Flora to Fight Bacterial Resistance, Part Two: The Best Source of Herbal Drugs and Pharmaceuticals, Volume 107 offers detailed information on the best African medicinal plants that could be useful for the development of efficient herbal drugs, as well as the best phytochemicals that could be explored as potential pharmaceuticals to efficiently tackle bacterial drug resistance. Chapters cover Phytochemistry and antibacterial potential of the genus Allanblackia, Phytochemistry and antibacterial potential of the genus Beilschmiedia, Phytochemistry and antibacterial potential of the genus Fagara, Phytochemistry and antibacterial potential of the genus Garcinia, Harungana madagascariensis as a source of antibacterial agents, Hypericum roeperianum as a source of antibacterial agents, and much more.

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components offers scientists a single source aimed at fighting specific multidrug-resistant (MDR) microorganisms such as bacteria, protozoans, viruses and fungi using natural products. This essential reference discusses herbal extracts and essential oils used or under investigation to treat MDR infections, as well as those containing antimicrobial activity that could be of potential interest in future studies against MDR microorganisms. The need to combat multidrug-resistant microorganisms is an urgent one and this book provides important coverage of mechanism of action, the advantages and disadvantages of using herbal extracts, essential oils and their components and more to aid researchers in effective antimicrobial drug discovery - Addresses the need to develop safe and effective approaches to coping with resistance to all classes of antimicrobial drugs - Provides readers with current evidence-based content aimed at using herbal extracts and essential oils in antimicrobial drug development - Includes chapters devoted to the activity of herbal products against herpes, AIDS, tuberculosis, drug-resistant cancer cells and more

Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.

Summary report published as technical document with reference number: WHO/HSE/PED/AIP/2014.2.

Our ability to treat common bacterial infections with antibiotics goes back only 65 years. However, the authors of this report make it clear that sustaining a supply of effective and affordable antibiotics cannot be without changes to the incentives facing patients, physicians, hospitals, insurers, and pharmaceutical manufacturers. In fact, increasing resistance to these drugs is already exacting a terrible price. Every day in the United States, approximately 172 men, women, and children die from infections caused by antibiotic-resistant bacteria in hospitals alone. Beyond those deaths, antibiotic resistance is costing billions of dollars through prolonged hospital stays and the need for doctors to resort to ever more costly drugs to use as substitute treatments. Extending the Cure presents the problem of antibiotic resistance as a conflict between individual decision makers and their short-term interest and the interest of society as a whole, in both present and future: The effort that doctors make to please each patient by prescribing a drug when it might not be properly indicated, poor monitoring of discharged patients to ensure that they do not transmit drug-resistant pathogens to other persons, excesses in the marketing of new antibiotics, and the broad overuse of antibiotics all contribute to the development and spread of antibiotic-resistant bacteria. The book explores a range of policy options that would encourage patients, health care providers, and managed care organizations to serve as more responsible stewards of existing antibiotics as well as proposals that would give pharmaceutical firms greater incentives to develop new antibiotics and avoid overselling. If the problem continues unaddressed, antibiotic resistance has the potential to derail the health care system and return us to a world where people of all ages routinely die from simple infections. As a basis for future research and a spur to a critically important dialogue, Extending the Cure is a fundamental first step in addressing this public health crisis. The Extending the Cure project is funded in part by the Robert Wood Johnson Foundation through its Pioneer Portfolio.

This publication provides a comprehensive and scientifically accurate guide to the best-known and most important medicinal plants, including those of special commercial or historical interest. It includes descriptions of more than 300 medicinal plants and their close relatives, with each entry summarising botanical background, geographical origin, therapeutic category, historical and modern uses, active ingredients, and pharmacological effects. Over 500 full-color photographs are included to assist in the identification of the plants.